| Poison undoer | 13 |
| Counteracting agent | 19 |
| Toxic avenger? | 14 |
| Remedy counteracting poison | 27 |
| Poison neutralizer | 18 |
| Poison counteracter | 19 |
| First-aid info | 14 |
| Counteractive remedy | 20 |
| Counteractive agent | 19 |
| Counteractant | 13 |
| Remedies | 8 |
| Poison remedies | 15 |
| Snake bite remedies | 19 |
| Remedies for poisons | 20 |
| Counteractive agents | 20 |
| Civil War battle site | 21 |
| 1862 battle site | 16 |
| 1862 Maryland battle site | 25 |
| Site of fierce Civil War battle | 31 |
| Site of Civil War's bloodiest battle | 40 |
| McClellan battle site | 21 |
| Maryland's historic ___ Creek | 33 |
| It led to the Emancipation Proclamation | 39 |
| First major Civil War battle on Union soil | 42 |
| Bloody Civil War battleground | 29 |
| Bloody Civil War battle site of September, 1862 | 47 |
| Bloody battleground for Lee | 27 |
| 1862 invasion battle site | 25 |
| "The Victor of ___" (Melville poem about the Civil War) | 65 |
| It stimulates the immune system | 31 |
| Immunologist's concern | 26 |
| Immune response trigger | 23 |
| Immunity trigger | 16 |
| Immune system booster | 21 |
| Substance used in immunology | 28 |
| Reactive toxin | 14 |
| Infection-curbing agent | 23 |
| Immune response stimulus | 24 |
| Immune response cause | 21 |
| Cause of an immune response | 27 |
| Body toxin | 10 |
| A or B in blood typing, e.g. | 28 |
| Stopover | 8 |
| West Indies island | 18 |
| Caribbean cruise stop | 21 |
| Leeward island | 14 |
| One of the Leeward Islands | 26 |
| Columbus discovery of 1493 | 26 |
| West Indies resort island | 25 |
| St. John's is its capital | 29 |
| St. Johns's island | 22 |
| Its leading city is St. John's | 34 |
| Island near Barbuda | 19 |
| Island named by Columbus in 1493 | 32 |
| Island Columbus reached in 1493 | 31 |
| Caribbean island whose original name was Waladli | 48 |
| Caribbean island split into six parishes | 40 |
| Barbuda's island partner | 28 |
| 1493 Columbus landing site | 26 |
| His capital is St. John's | 29 |
| Barbudan's neighbor | 23 |
| Willy Loman, for one | 20 |
| Not-so-noble protagonist | 24 |
| Captain Jack Sparrow, e.g. | 26 |
| Tony Soprano, for one | 21 |
| Questionable lead | 17 |
| Protagonist found lacking | 25 |
| Raskolnikov in "Crime and Punishment," e.g. | 53 |
| Protagonist with likability issues | 34 |
| Protagonist of a sort | 21 |
| Protagonist in fiction | 22 |
| Nontraditional protagonist | 26 |
| Mad Max or Dirty Harry | 22 |
| Lucky Jim, for one | 18 |
| Literary nonachiever | 20 |
| Leopold Bloom, e.g. | 19 |
| Flawed protagonist | 18 |
| Film noir protagonist | 21 |
| Either lead in "Easy Rider," e.g. | 43 |
| Drama character | 15 |
| Don Quixote or Leopold Bloom | 28 |
| Dirty Harry, notably | 20 |
| Dirty Harry, e.g. | 17 |
| Dirty Harry or Tony Soprano | 27 |
| Cool Hand Luke, for one | 23 |
| Character lacking courage | 25 |
| Atypical protagonist | 20 |
| Right-brained? | 14 |
| Math figure | 11 |
| Math class calculation | 22 |
| Math function | 13 |
| Slide rule reading | 18 |
| What 100 is to 2, in the base 10 | 32 |
| Pre-calc calculation | 20 |
| Number corresponding to an exponent | 35 |
| Math table entry | 16 |
| Certain math number | 19 |
| 10,000, for 4, in base 10, e.g. | 31 |
| Physicist's study | 21 |
| Particle physics subject | 24 |