| Ontario neighbour | 17 |
| One of the five | 15 |
| One of Jay Gould's railroads | 32 |
| One of five bodies of water | 27 |
| One of a noted geographical quintet | 35 |
| One of a notable quintet | 24 |
| One of a great quintet | 22 |
| One of a great five | 19 |
| One Great Lake | 14 |
| Old name in railroads | 21 |
| Ohio's Lake ___ College | 27 |
| Ohio native | 11 |
| Ohio lake | 9 |
| O'Neill's ___ Smith | 27 |
| Noted canal | 11 |
| Notable canal | 13 |
| Northwestern Pennsylvania city | 30 |
| Northwest Pennsylvania county | 29 |
| Northwest Pennsylvania city | 27 |
| Northernmost Pennsylvania county | 32 |
| Niagara River's source | 26 |
| New York port | 13 |
| New York Indian | 15 |
| New York county south of Niagara | 32 |
| New York canal opened in 1825 | 29 |
| Neighbor of Ontario and Huron | 29 |
| Name of a lake and canal | 24 |
| Member of the Cat Nation | 24 |
| Large lake named after a tribe | 30 |
| Large freshwater lake | 21 |
| Lake where Perry fought | 23 |
| Lake touching four states | 25 |
| Lake that sounds weird | 22 |
| Lake that sounds mysterious | 27 |
| Lake that sounds creepy | 23 |
| Lake that feeds the Niagara River | 33 |
| Lake that Canada's Point Pelee National Park is on | 54 |
| Lake surrounding Mohawk Island | 30 |
| Lake surrounding Canada's southernmost point | 48 |
| Lake seen from the Rock and Roll Hall of Fame | 45 |
| Lake or city | 12 |
| Lake on the border of four states | 33 |
| Lake next to the Rock and Roll Hall of Fame | 43 |
| Lake near the Rock and Roll Hall of Fame | 40 |
| Lake near Chautauqua | 20 |
| Lake in view from Cleveland | 27 |
| Lake in four states | 19 |
| Lake by the Jake | 16 |
| Lake between Huron and Ontario | 30 |
| Lake Amerind | 12 |
| Jolliet's lake | 18 |
| Jolliet discovery | 17 |
| Joliet discovery of 1669 | 24 |
| It feeds Niagara Falls | 22 |
| Iroquoian tongue | 16 |
| I-79 terminus | 13 |
| Hudson River canal | 18 |
| Great Lake port | 15 |
| Great Lake city | 15 |
| Gannon University city | 22 |
| Fourth-largest of the Great Lakes | 33 |
| Fort ___, Ontario | 17 |
| Extinct Indian group | 20 |
| Eleventh largest lake in the world | 34 |
| Eastern Indian | 14 |
| Eastern city on I-90 | 20 |
| Dunkirk's lake | 18 |
| Crossword constructor's favorite canal | 42 |
| County in Penna. | 16 |
| County in New York, Ohio, and Pennsylvania | 42 |
| Cleveland's waterfront | 26 |
| Cleveland's water | 21 |
| Cleveland's body of water | 29 |
| City on a same-named lake | 25 |
| City not far from Buffalo | 25 |
| City in the Keystone State | 26 |
| Cedar Point's lake | 22 |
| Cat Nation tribe | 16 |
| Cat Nation member | 17 |
| Canal, lake or city | 19 |
| Canal that Sal worked on, in song | 33 |
| Canal that opened in 1825 | 25 |
| Canal started in 1817 | 21 |
| Canal of Sal, in song | 21 |
| Canal of Rome | 13 |
| Canal for Sal | 13 |
| Canal finished in 1825 | 22 |
| Canal connecting the Great Lakes to the Atlantic | 48 |
| Canadian border lake | 20 |
| Buffalo's county or lake | 28 |
| Barge canal of song | 19 |
| American tribe | 14 |
| American canal | 14 |
| A great lake for sailing? | 25 |
| 15 miles of song | 16 |
| "The Flagship City" | 29 |
| "Mistake by the lake" lake | 36 |
| "Low bridge! Everybody down!" canal | 45 |
| ". . . 15 miles on the ___ Canal" | 43 |
| ''Low bridge, everyone down!'' canal | 52 |