| Protagonist in the highest-grossing film of 1985 | 48 |
| Protagonist of "The Kite Runner" | 42 |
| Protagonist of "The Matrix" | 37 |
| Protagonist of Clancy's books | 33 |
| Protagonist of several Jasper Fforde novels | 43 |
| Protagonist of some Clancy books | 32 |
| Protagonist of The Book Thief ___ Meminger | 42 |
| Protagonist with likability issues | 34 |
| Protagonists in "Star Wars" | 37 |
| Protégé of Lorenzo the Magnificent | 40 |
| Protégé of Nicholas Nickleby | 34 |
| Protect from cracking, as one's phone | 41 |
| Protect from erosion, as a riverbank | 36 |
| Protect from the enemy, in a way | 32 |
| Protect your phone's sound with bar soaps! | 46 |
| Protect, as during a gym routine | 32 |
| Protect, in a way, with "over" | 40 |
| Protected from prying eyes, in a way | 36 |
| Protected from the elements, as an Element | 42 |
| Protected from the wind, in sailing | 35 |
| Protected, as a surgeon's hands | 35 |
| Protected, as horses' hooves | 32 |
| Protected, like a Round Table knight | 36 |
| Protection against cats and dogs? | 33 |
| Protection against lurid search content | 39 |
| Protection for a boat's hull | 32 |
| Protection for a fairy-tale dwarf's brain? | 46 |
| Protection for a truck's cargo | 34 |
| Protection for some I.R.A.'s | 32 |
| Protection for some investors (abbr.) | 37 |
| Protection for someone on the run? | 34 |
| Protection from making a tennis error? | 38 |
| Protection method from flying debris | 36 |
| Protection with a suspension to lessen impact | 45 |
| Protection wound around bicycles | 32 |
| Protections for princely palaces | 32 |
| Protective cover for an iPod or cellphone | 41 |
| Protective covering in a canary's coop | 42 |
| Protective covering used by Roman troops | 40 |
| Protective device for a bistro engraver? | 40 |
| Protective feature of most power strips | 39 |
| Protective gear for public disorder? | 36 |
| Protective structure for a snowball war | 39 |
| Protective wear for airborne toxins | 35 |
| Protective wear for lobster eaters | 34 |
| Protector of a car's front end | 34 |
| Protector of Joshua's spies: Var. | 37 |
| Protector of sailors, by tradition | 34 |
| Protector of Stitch in a Disney film | 36 |
| Protectors of the Galactic Republic | 35 |
| Protectors of the reef ecosystem? | 33 |
| Protects from the enemy, in a way | 33 |
| Protects one's rights, in a way | 35 |
| Protein and weight-lifting, for two | 35 |
| Protein building block, for short | 33 |
| Protein derivatives, such as gelatin | 36 |
| Protein picture sketched in like two seconds? | 45 |
| Protein synthesis molecule, for short | 37 |
| Protein that allows skin to stretch | 35 |
| Protein-producing agent, for short | 34 |
| Protein-rich alternative to the patch? | 38 |
| Protest activity for farm subsidy opponents? | 44 |
| Protest against fiery roadsters? | 32 |
| Protest outside the MGM Grand, perhaps? | 39 |
| Protest singer-songwriter Phil ___ | 34 |
| Protest that eventually dies out? | 33 |
| Protestant group in Northern Ireland | 36 |
| Protestant in Garrison Keillor stories: abbr. | 45 |
| Protestant Reformation leader John | 34 |
| Protestant who believes in the Book of Concord | 46 |
| Protested during a national anthem, say | 39 |
| Protesting, but not pro-testing? | 32 |
| Protests in a campus dining hall, perhaps | 41 |
| Protests in Tahrir Square were a part of it | 43 |
| Proteus and Valentine, for two noted examples | 45 |
| Proteus's domain, with "the" | 42 |
| Proto-matter from which the universe was made | 45 |
| Proto-___-European (early language) | 35 |
| Proton or electron, take your pick | 34 |
| Proton-enhanced form of reproduction? | 37 |
| Proton-enhanced instrument of torture? | 38 |
| Protozoa with pseudopodia (var.) | 32 |
| Protozoan studied in biology class | 34 |
| Protozoan that can photosynthesize | 34 |
| Protracted sound from the undecided | 35 |
| Proud bird with beautiful feathers | 34 |
| Proud black woman, per Urban Dictionary | 39 |
| Proud liberal's apology ... or is it? | 41 |
| Proud papa's handout, perhaps | 33 |
| Proud, energetic, domineering ones, they say | 44 |
| Proulx's "Brokeback Mountain," e.g. | 49 |
| Proust character married to Odette | 34 |
| Proust's "Remembrance of Things __" | 49 |
| Proust's "Remembrance ___" | 40 |
| Prouty novel "Stella ---" | 35 |
| Prov. between Manitoba and Quebec | 33 |
| Prov. bordering four Great Lakes | 32 |
| Prov. in the Gulf of St. Lawrence | 33 |
| Prov. touching a lake of the same name | 38 |
| Prov. whose capital is Charlottetown | 36 |