| Profligate person | 17 |
| Profligately eye | 16 |
| Profligates | 11 |
| Profound | 8 |
| Profound 45. Run-down | 21 |
| Profound differences | 20 |
| Profound fear | 13 |
| Profound one | 12 |
| Profound painting? | 18 |
| Profound philosophers | 21 |
| Profound quip (Part 2) | 22 |
| Profound quip (Part 3) | 22 |
| Profound respect | 16 |
| Profound reverence | 18 |
| Profound sleep | 14 |
| Profound sleeps | 15 |
| Profound state of unconsciousness | 33 |
| Profound void | 13 |
| Profound wonder | 15 |
| Profound; abstruse | 18 |
| Profoundly | 10 |
| Profoundly dark | 15 |
| Profoundly deep sleep | 21 |
| Profoundly different | 20 |
| Profoundly dislikes | 19 |
| Profoundly impressed | 20 |
| Profoundly knowledgeable | 24 |
| Profoundly lethargic state | 26 |
| Profoundly philosophical | 24 |
| Profoundly respectful | 21 |
| Profoundly round | 16 |
| Profoundly wise | 15 |
| Profoundly, to poets | 20 |
| Profoundness | 12 |
| Profs have them | 15 |
| Profs may employ them | 21 |
| Profs' aides | 16 |
| Profs' aides: Abbr. | 23 |
| Profs' boss | 15 |
| Profs' concoctions | 22 |
| Profs' degrees | 18 |
| Profs' degs. | 16 |
| Profs' help | 15 |
| Profs' helpers | 18 |
| Profs' helpers, for short | 29 |
| Profs' helpers: abbr. | 25 |
| Profs' org. | 15 |
| Profs' posers, at times | 27 |
| Profs' protégés, briefly | 34 |
| Profs, usually | 14 |
| Profs.' aides | 17 |
| Profs.' degrees | 19 |
| Profs.' helpers | 19 |
| Profs., often | 13 |
| Profundity | 10 |
| Profundo or buffo | 17 |
| Profuse | 7 |
| Profuse thanks, e.g. | 20 |
| Profusely | 9 |
| Profusely polite | 16 |
| Profusion | 9 |
| Profusion, as of color | 22 |
| Prog band that turns 40 in 2008 | 31 |
| Prog band who partly inspired "This Is Spinal Tap" | 60 |
| Prog band whose lead singer was once a milkman | 46 |
| Prog band with a Grammy-nominated concert video directed by Steven Soderbergh | 77 |
| Prog rock band my parents saw on their first date | 49 |
| Prog rock band with guitarist Robert Fripp | 42 |
| Prog rock band with two former Yes members | 42 |
| Prog-metal band Animals ___ | 27 |
| Prog-rock band from S.F. | 24 |
| Prog-rock band of the 1970s | 27 |
| Prog-rockers on the "Xanadu" soundtrack | 49 |
| Prog-rockers Porcupine ___ | 26 |
| Prog. code used to create Web pages | 35 |
| Prog. Cons. opponent, in Canada | 31 |
| Prog. Cons. rival, in Canada | 28 |
| Prog. discontinued at some campuses during the Vietnam War | 58 |
| Prog. for some cadets | 21 |
| Prog. interruption | 18 |
| Prog. listing | 13 |
| Prog. that introduced Brilliant Pebbles | 39 |
| Progenitor | 10 |
| Progenitor of the Edomites | 26 |
| Progenitor of the Hebrew alphabet | 33 |
| Progenitorial prefix | 20 |
| Progenitors | 11 |
| Progeny | 7 |
| Progeny of a sort | 17 |
| Progeny of an old block | 23 |
| Progeny of Aphrodite | 20 |
| Progeny of Eternity and Infinity, in Marvel Comics | 50 |
| Progeny: Abbr. | 14 |
| Progesterone expert and author, Dr. John ___ | 44 |
| Progesterone source | 19 |
| Progesterone, for example | 25 |
| Prognosis | 9 |
| Prognostic | 10 |
| Prognosticate | 13 |
| Prognosticates | 14 |