| Two quarters | 12 |
| Two quarters of an Isthmian city | 32 |
| Two quartets | 12 |
| Two quartets combined | 21 |
| Two quartets side-by-side | 25 |
| Two quartets, combined | 22 |
| Two quartets? | 13 |
| Two Queens stadiums | 19 |
| Two racing Unsers | 17 |
| Two Ralph Waldo Emerson collections | 35 |
| Two reals, in days of old | 25 |
| Two reasons to avoid a dog kennel? | 34 |
| Two residents of the Old Man's beard, in a Lear verse | 57 |
| Two rockers make a "John" sandwich? | 45 |
| Two Roman generals | 18 |
| Two Roman statesmen | 19 |
| TWO ROOMS | 9 |
| Two scoops of ice cream | 23 |
| Two score | 9 |
| Two score of low, thick lilies? | 31 |
| Two Scottish rivers | 19 |
| Two scout groups? | 17 |
| Two seater, maybe? | 18 |
| Two seater, often? | 18 |
| Two seater, perhaps? | 20 |
| Two seconds of Edgar Bergen during screen test (5) | 50 |
| Two selfless things | 19 |
| Two semesters | 13 |
| Two Senators (Vt.-Mich.) | 24 |
| Two shakes | 10 |
| Two shakes equivalent | 21 |
| Two shakes, with "a" | 30 |
| Two sharp turns | 15 |
| Two sheets to the wind | 22 |
| Two sheets to the wind? | 23 |
| Two shots, maybe | 16 |
| Two sides in a battle | 21 |
| Two sides of a triangle | 23 |
| Two sides of Pascal's triangle | 34 |
| Two silkworms raced and ended in --- | 37 |
| Two silkworms raced and ended in ___ | 36 |
| Two singers | 11 |
| Two sizes above sm. | 19 |
| Two sizes too small | 19 |
| Two slices of a loaf | 20 |
| Two smackers? | 13 |
| Two socks | 9 |
| Two socks, one hopes | 20 |
| Two solid days | 14 |
| Two sounds in one | 17 |
| Two Spanish explorers | 21 |
| Two Spanish provinces | 21 |
| Two square kilometers, for Monaco | 33 |
| Two squared | 11 |
| Two stars dating, e.g. | 22 |
| Two stars of "Paper Moon" | 35 |
| Two stars, maybe | 16 |
| Two states (Abbr.) | 18 |
| Two states, with "the" | 32 |
| Two steeds? | 11 |
| Two steps on a scale | 20 |
| Two strikes? | 12 |
| Two string quartets | 19 |
| Two strokes more than an eagle | 30 |
| Two strokes of bad luck, literally | 34 |
| Two tablets perhaps | 20 |
| Two tablets every 12 hours, say | 31 |
| Two tablets every six hours, e.g. | 33 |
| Two tablets, maybe | 18 |
| Two tablets, often | 18 |
| Two tablets, perhaps | 20 |
| Two tablets, say | 16 |
| Two taker | 9 |
| Two teaspoonfuls, e.g. | 22 |
| Two teaspoons, e.g. | 19 |
| Two teaspoons, say | 18 |
| Two teleprompters might flank one | 33 |
| Two tens, e.g. | 14 |
| Two tens, for one | 17 |
| Two that are one | 16 |
| Two that are trouble | 20 |
| Two that match | 14 |
| Two thespian Chaneys | 20 |
| Two things a beer-swilling Rottweiler can do? | 45 |
| Two things at Ms. Gordimer's party? | 39 |
| Two things found at an Alaska casino? | 37 |
| Two things heard at a well-received session by Mehmet? | 54 |
| Two things in a pet-loving monk's cell? | 43 |
| Two things in Clinton's poolroom? | 37 |
| Two things involving peer pressure to drink? | 44 |
| Two things needed by old-time firefighters? | 43 |
| Two things not to mess with in the Old West? | 44 |
| Two things of concern to a math-loving nurse? | 45 |
| Two things seen beside James Bond at a casino? | 46 |
| Two things seen in the toros' tavern after a grueling corrida? | 66 |
| Two things that might be found in a dining room | 47 |
| Two things to fold | 18 |
| Two things to read | 18 |
| Two thousand pounds | 19 |
| Two threes, for one | 19 |