| Large spotted cats | 18 |
| Large sports structure | 22 |
| Large sport fish | 16 |
| Large spoon | 11 |
| Large spiral shell | 18 |
| Large species of deer | 21 |
| Large Spanish ships of old | 26 |
| Large southern constellation | 28 |
| Large South African antelope | 31 |
| Large source of income in Fla. | 30 |
| Large soup dish | 15 |
| Large software manufacturer | 27 |
| Large sofas | 11 |
| Large societal group | 20 |
| Large social gathering, e.g. | 28 |
| Large snake or James Clavell best seller | 40 |
| Large snake mackerel | 20 |
| Large snake | 11 |
| Large snail | 11 |
| Large sloths | 12 |
| Large slipknots | 15 |
| Large slices | 12 |
| Large slice | 11 |
| Large sizes, briefly | 20 |
| Large single-edged knives | 25 |
| Large silvery fish | 18 |
| Large Sicilian volcano | 22 |
| Large shrimp sauteed in oil | 27 |
| Large shrimp | 12 |
| Large shoe width | 16 |
| Large shoe specification | 24 |
| Large shoe size | 15 |
| Large ship | 10 |
| Large sharks | 12 |
| Large shark | 11 |
| Large shade tree | 16 |
| Large serving dishes | 20 |
| Large serving bowls | 19 |
| Large serving bowl | 18 |
| Large server | 12 |
| Large series, as of tests | 25 |
| Large separation | 16 |
| Large seed of the alligator pear | 32 |
| Large section in an atlas | 25 |
| Large seaweed | 13 |
| Large search area | 17 |
| Large seabirds | 14 |
| Large seabird | 13 |
| Large sea turtles | 17 |
| Large sea snails | 16 |
| Large sea snail | 15 |
| Large sea ray | 13 |
| Large sea ducks | 15 |
| Large sea duck | 14 |
| Large sea creature | 18 |
| Large sea birds | 15 |
| Large sea bird | 14 |
| Large scissors | 14 |
| Large school of fish | 20 |
| Large scarf | 11 |
| Large scale | 11 |
| Large saxhorn | 13 |
| Large satellite of Jupiter | 26 |
| Large sandwich, for short | 25 |
| Large sandwich | 14 |
| Large salmon | 12 |
| Large salamander | 16 |
| Large sailing vessel | 20 |
| Large sailing ship | 18 |
| Large S.A. snake | 16 |
| Large S.A. rodent | 17 |
| Large S.A. bird | 15 |
| Large Russian lake | 18 |
| Large ruminant | 14 |
| Large rosary bead | 17 |
| Large rooms | 11 |
| Large room or hall | 18 |
| Large room | 10 |
| Large Roman rooms | 17 |
| Large roll of money | 19 |
| Large roll of dough | 19 |
| Large roll | 10 |
| Large rodents | 13 |
| Large rodent also known as a spotted cavy | 41 |
| Large rodent | 12 |
| Large revolver | 14 |
| Large retail stores | 19 |
| Large retail store | 18 |
| Large retail outlets | 20 |
| Large retail complex | 20 |
| Large reservoir on the Nile | 27 |
| Large reptile | 13 |
| Large region in E Asia | 22 |
| Large reference work, perhaps | 29 |
| Large reference book | 20 |
| Large reference | 15 |
| Large ref. book | 15 |
| Large reed instrument | 21 |
| Large red hogs | 14 |
| Large red hog with drooping ears | 32 |