| A series of curls | 17 |
| A series of chirps | 18 |
| A series of "insurmountable obstacles on the road to imminent disaster," per Tom Stoppard | 99 |
| A sergeant might ask soldiers to pick it up | 43 |
| A sergeant might ask a soldier to pick it up | 44 |
| A sergeant may order one | 24 |
| A September sign | 16 |
| A Seoul G.I. | 12 |
| A Sentimental Journey author | 31 |
| A sentence | 10 |
| A sensor | 8 |
| A sense | 7 |
| A Senator from Ga. | 18 |
| A Semitic language | 18 |
| A Semite | 8 |
| A semisolid | 11 |
| A semirural area | 16 |
| A seminomadic Muslim | 20 |
| A semihard yellow cheese | 24 |
| A semi might make one | 21 |
| A semi lacks a front one | 24 |
| A seer may read them | 20 |
| A seemingly endless series | 26 |
| A seeming eternity | 18 |
| A seed might get one | 20 |
| A Sedgwick | 10 |
| A Sedge of ______ | 17 |
| A sedge of ______ | 18 |
| A secy might take one from a CEO | 32 |
| A security guard might be on this | 33 |
| A security guard might ask you to do this | 41 |
| A security | 10 |
| A section of Yankee Stadium's golf course? | 46 |
| A section of New York City that sounds like a person | 52 |
| A Secretary of State for F.D.R. | 31 |
| A secretary might take it | 25 |
| A secret may be told in one | 27 |
| A second time | 13 |
| A second shift, possibly | 24 |
| A second self | 13 |
| A second helping | 16 |
| A Sec. of Treasury under Truman | 31 |
| A señor has one | 18 |
| A seasoning, in Savoie | 22 |
| A seasoning | 11 |
| A season: Abbr. | 15 |
| A season, in Arles | 18 |
| A season in Sedan | 17 |
| A season in India, with "the" | 39 |
| A season abroad | 15 |
| A search may be done with it | 28 |
| A seamstress should be __ | 25 |
| A sea was named for him | 23 |
| A sea mon ami | 14 |
| A sea | 5 |
| A scythe may cut one | 20 |
| A scuttle might scoop from it | 29 |
| A Scrooge portrayer | 19 |
| A script, in printing | 21 |
| A screw loose | 13 |
| A screen Chan | 13 |
| A screech may accompany it | 26 |
| A scream | 8 |
| A Scrabble tile | 15 |
| A scout may do a good one | 25 |
| A Scout | 7 |
| A scoundrel on the south side of Arkansas peak (6) | 50 |
| A Scottish loch, for example | 28 |
| A Scottish isle | 15 |
| A Scottish Highlander | 21 |
| A Scott | 7 |
| A Scot has one | 14 |
| A Scot and his relatives | 24 |
| A SCORPIO | 9 |
| A scoreless inning makes it go down | 35 |
| A scoreboard listing | 20 |
| A score, barely | 15 |
| A score of fins | 15 |
| A score has two | 15 |
| A score | 7 |
| A scion of Shem | 15 |
| A science: Abbr. | 16 |
| A science | 9 |
| A sci. degree | 13 |
| A sci. | 6 |
| A sci-fi writer's award | 27 |
| A schussboomer uses them | 24 |
| A Schumann | 10 |
| A schooner has two | 18 |
| A school of _____ | 17 |
| A school mo. | 12 |
| A school might be found using it | 32 |
| A sch. | 6 |
| A scene of Caesar's conquests | 33 |
| A scarab beetle with a heart-shaped mark on its wing covers was named after this adventurer | 91 |
| A scanning | 10 |
| A Scandinavian | 14 |
| A scandal often ruins one | 25 |
| A saxophonist | 13 |
| A saxophone has one | 19 |