| ___ split | 9 |
| ___ splints (jogger's complaint) | 36 |
| ___ splints | 11 |
| ___ splicing | 12 |
| ___ spit (kiss) | 15 |
| ___ Spirit (stealth bomber) | 27 |
| ___ spirit | 10 |
| ___ Spin (classic toy) | 22 |
| ___ spill | 9 |
| ___ Spiegel magazine | 20 |
| ___ Spiegel (Hamburger's rag) | 33 |
| ___ Spiegel (German newsmagazine) | 33 |
| ___ Spiegel (German magazine) | 29 |
| ___ Spiegel | 11 |
| ___ Spice (Victoria Beckham) | 28 |
| ___ Spice (nickname for Victoria Beckham) | 41 |
| ___ spheroid (football, to sports writers) | 42 |
| ___ Sperry, aeronautics pioneer | 31 |
| ___ Spenlow (Dickens girl) | 26 |
| ___ Spencer, brother of Princess Diana | 38 |
| ___ spell over | 14 |
| ___ spell on | 12 |
| ___ spell (took a load off) | 27 |
| ___ spell (rest) | 16 |
| ___ spell (relax) | 17 |
| ___ spell | 9 |
| ___ Speedy (rival of Kinko's) | 33 |
| ___ Speedy (photocopying store) | 31 |
| ___ Speedwagon, rock group | 26 |
| ___ Speedwagon of rock | 22 |
| ___ Speedwagon (rock group) | 27 |
| ___ Speedwagon (1970s-'80s band) | 36 |
| ___ Speedwagon ("Keep on Loving You" band) | 52 |
| ___ Speedwagon | 14 |
| ___ Speed Wagon (vintage auto) | 30 |
| ___ Speed Wagon (old vehicle) | 29 |
| ___ speed | 9 |
| ___ Spee (old German warship) | 29 |
| ___ Spee | 8 |
| ___ Specter (Pennsylvania senator for 30 years) | 47 |
| ___ special | 11 |
| ___ speaking (group recitation) | 31 |
| ___ Speaker | 11 |
| ___ speak (as it were) | 22 |
| ___ speak | 9 |
| ___ SpÃritus (Cuban city) | 28 |
| ___ Sparks, memorable sourpuss | 30 |
| ___ Spark, creator of Miss Jean Brodie | 38 |
| ___ Spalko, Indiana Jones villainess | 36 |
| ___ Spalko, ("Indiana Jones and the Kingdom of the Crystal Skull" villain) | 84 |
| ___ spades (top bridge card) | 28 |
| ___ spades (highest card in a deck) | 35 |
| ___ spades | 10 |
| ___ spade a spade | 17 |
| ___ Spade (handbag company) | 27 |
| ___ Space Holiday | 17 |
| ___ space | 9 |
| ___ Southwest Grill (restaurant chain) | 38 |
| ___ South | 9 |
| ___ Sousé (W.C. Fields in "The Bank Dick") | 55 |
| ___ soup to nuts (everything) | 29 |
| ___ soup (sushi starter) | 24 |
| ___ soup (starter at a Japanese restaurant) | 43 |
| ___ soup (Laotian delicacy) | 27 |
| ___ soup (heavy fog) | 20 |
| ___ soup (fog) | 14 |
| ___ soup (dense fog) | 20 |
| ___ soup (Chinese favorite) | 27 |
| ___ soup (Charleston dish) | 26 |
| ___ soup | 8 |
| ___ Soundsystem (subject of the 2012 documentary "Shut Up and Play the Hits") | 87 |
| ___ Soundsystem (band with the 2010 album "This Is Happening") | 72 |
| ___ Soundsystem | 15 |
| ___ Sound, Washington | 21 |
| ___ Sound, Wash. | 16 |
| ___ Sound, Fla. resort | 22 |
| ___ Sound, Fla. | 15 |
| ___ Sound Machine | 17 |
| ___ Sound (Washington estuarine system) | 39 |
| ___ Sound | 9 |
| ___ Souls College, Oxford | 25 |
| ___ soul (nobody) | 17 |
| ___ soul (no one) | 17 |
| ___ Soul (hip-hop group) | 24 |
| ___ soul (contract with Satan) | 30 |
| ___ souci (free from worry) | 27 |
| ___ souci (carefree) | 20 |
| ___ souci | 9 |
| ___ sort (in some respects) | 27 |
| ___ sort | 8 |
| ___ sorry | 9 |
| ___ Sorrel (woman in a love triangle in "Adam Bede") | 62 |
| ___ Sorensen, "Kennedy" author | 40 |
| ___ soprano | 11 |
| ___ Sophia, church built by Justinian | 37 |
| ___ Sophia (Istanbul landmark) | 30 |
| ___ sont | 8 |
| ___ songs | 9 |
| ___ song (inexpensively) | 24 |
| ___ song (farewell appearance) | 30 |