| Major course | 12 |
| Major country with the longest life expectancy | 46 |
| Major cotton producer | 21 |
| Major corporation that was headquartered in Pennsylvania | 56 |
| Major copper producer | 21 |
| Major copper exporter | 21 |
| Major cooling-off period | 24 |
| Major contributor to Central Park's Strawberry Fields | 57 |
| Major constellation? | 20 |
| Major constellation | 19 |
| Major conflicts | 15 |
| Major conflict | 14 |
| Major conclusion? | 17 |
| Major conclusion | 16 |
| Major component of the euro symbol | 34 |
| Major component of soapstone | 28 |
| Major component of Saturn's rings | 37 |
| Major component of kidney stones | 32 |
| Major complication | 18 |
| Major company renamed in 1997 | 29 |
| Major company in metallic products | 34 |
| Major command | 13 |
| Major college football's winningest coach | 45 |
| Major coll. fraternity | 22 |
| Major cold spells | 17 |
| Major coffee-bean producer | 26 |
| Major coffee exporter | 21 |
| Major cocoa-producing country | 29 |
| Major cocoa producer | 20 |
| Major cocoa exporter | 20 |
| Major coca producer | 19 |
| Major club | 10 |
| Major closing? | 14 |
| Major cleanups follow them | 26 |
| Major civic bldgs. | 18 |
| Major city on the Ruhr | 22 |
| Major city on the Missouri | 26 |
| Major city off the coast of China | 33 |
| Major city of southwest Colombia | 32 |
| Major city of Norway | 20 |
| Major city of ancient Crete | 27 |
| Major chunk of Earth's surface | 34 |
| Major chipmaker | 15 |
| Major chip maker | 16 |
| Major Chinese seaport | 21 |
| Major Chinese energy source | 27 |
| Major Chinese dialect | 21 |
| Major Chicago tourist attraction | 32 |
| Major chess piece | 17 |
| Major chaser | 12 |
| Major character in the bestseller "Disney War" | 56 |
| Major celeb | 11 |
| Major Côte d'Ivoire export | 33 |
| Major cause of inflation? | 25 |
| Major cause of inflation | 24 |
| Major cause | 11 |
| Major caucus site | 17 |
| Major catch for a bride? | 24 |
| Major car part | 14 |
| Major car manufacturer | 22 |
| Major Canadian short-story writer | 33 |
| Major can maker | 15 |
| Major campaign contributor | 26 |
| Major California vintner | 24 |
| Major Calif.-to-Fla. route | 26 |
| Major Cali music store | 22 |
| Major CA airport | 16 |
| Major C.P.A. employer | 21 |
| Major burden | 12 |
| Major bummers | 13 |
| Major bummer | 12 |
| Major budget item | 17 |
| Major broadcaster | 17 |
| Major British publisher | 23 |
| Major brand in heating and air conditioning | 43 |
| Major Bowes's hour | 22 |
| Major Bowes updated? | 20 |
| Major Boston street | 19 |
| Major bore | 10 |
| Major book about a leader of the lighter industry? | 50 |
| Major bollix | 12 |
| Major Boeing client | 19 |
| Major body vessel | 17 |
| Major body arteries | 19 |
| Major blunders | 14 |
| Major blueberry-producing state | 31 |
| Major blows | 11 |
| Major bloodline? | 16 |
| Major bloodline | 15 |
| Major blood vessels | 19 |
| Major blood vessel | 18 |
| Major blood supplier | 20 |
| Major blood lines | 17 |
| Major blood line | 16 |
| Major blood group | 17 |
| Major blood conveyor | 20 |
| Major blood carrier | 19 |
| Major Black Sea port | 20 |
| Major birth news | 16 |
| Major bashes | 12 |