| Major Italian tourist site | 26 |
| Major Italian fashion house | 27 |
| Major Istanbul attraction | 25 |
| Major ISP | 9 |
| Major irritant for American colonists | 37 |
| Major irritant | 14 |
| Major Iraqi river | 17 |
| Major investigation | 19 |
| Major introduction? | 19 |
| Major intersection | 18 |
| Major Internet service provider, for short | 42 |
| Major interest, slangily | 24 |
| Major insurance risk | 20 |
| Major injustice | 15 |
| Major influence in '60s music | 33 |
| Major industry of Madeira | 25 |
| Major industrial center near Manchester | 39 |
| Major Indonesian export | 23 |
| Major indignation | 17 |
| Major Indian export | 19 |
| Major inconveniences | 20 |
| Major inconvenience | 19 |
| Major in govt. | 14 |
| Major in golf | 13 |
| Major in astronomy? | 19 |
| Major in | 8 |
| Major impact, as of an attack | 29 |
| Major hurricane of 2008 | 23 |
| Major hurricane of 2005 | 23 |
| Major hurdle, metaphorically | 28 |
| Major hub of Japan | 18 |
| Major Houlihan, e.g. | 20 |
| Major Houlihan portrayer | 24 |
| Major hostilities | 17 |
| Major Hoople, for one | 21 |
| Major Hoople's word | 23 |
| Major Hoople's outburst, in old comics | 42 |
| Major Hoople's holler | 25 |
| Major Hoople's first name | 29 |
| Major Hoople's expletives | 29 |
| Major Hoople's expletive | 28 |
| Major Hoople's exclamation, in the comics | 45 |
| Major Hoople's epitaph | 26 |
| Major Hoople's cry | 22 |
| Major Hoople's cries | 24 |
| Major Hoople's "whoops" | 37 |
| Major Hoople's "drat" | 35 |
| Major Hoople expletive | 22 |
| Major Hoople | 12 |
| Major home security corp. | 25 |
| Major Hollywood thoroughfare | 28 |
| Major Hollywood attraction | 26 |
| Major holder of gold | 20 |
| Major highway from Fla. to Calif. | 33 |
| Major highway | 13 |
| Major heart vessels | 19 |
| Major heart vessel | 18 |
| Major headaches | 15 |
| Major headache | 14 |
| Major Hawaiian plant | 20 |
| Major hassle | 12 |
| Major happenings | 16 |
| Major happening | 15 |
| Major handgun manufacturer | 26 |
| Major growth areas? | 19 |
| Major growth areas | 18 |
| Major govt.-owned power producer | 32 |
| Major golf tourneys | 19 |
| Major golf tourney | 18 |
| Major golf event | 16 |
| Major gold-mining area, with "the" | 44 |
| Major gold exporter of Africa | 29 |
| Major global crop | 17 |
| Major glitch | 12 |
| Major gift for a teen | 21 |
| Major Germanic god | 18 |
| Major German river, to a Frenchman | 34 |
| Major German river, in German | 29 |
| Major German export | 19 |
| Major General Wallace | 21 |
| Major General Jesse Lee ___ | 27 |
| Major gains | 11 |
| Major functions | 15 |
| Major function | 14 |
| Major fruit canner | 18 |
| Major French publisher of reference works | 41 |
| Major French newspaper | 22 |
| Major French city | 17 |
| Major French airport | 20 |
| Major forces | 12 |
| Major force in chess | 20 |
| Major for civic-minded frosh | 28 |
| Major football competition | 26 |
| Major food service company | 26 |
| Major following? | 16 |
| Major followers? | 16 |
| Major followers | 15 |
| Major follower? | 15 |
| Major follower | 14 |
| Major flop | 10 |