| One small step for a man? | 25 |
| One smeared in England | 22 |
| One socially challenged | 23 |
| One sock, to the other | 22 |
| One sometimes called a cougar | 29 |
| One sometimes clay-footed | 25 |
| One soothed by music, perhaps | 29 |
| One sound of contentment | 24 |
| One source of pleasure | 22 |
| One source of shingles | 22 |
| One source of vitamin C | 23 |
| One south of the border | 23 |
| One spade, two clubs, etc. | 26 |
| One spared in a sacrifice | 25 |
| One speaking positively | 23 |
| One specializing in slugging | 28 |
| One sponsored at a baptism | 26 |
| One spotted in an alley | 23 |
| One spreading news, in a way | 28 |
| One stage of development | 24 |
| One stalking lions or tigers | 28 |
| One standing at the bar | 23 |
| One standing out in a field? | 28 |
| One starts with difficulty | 26 |
| One stationed at a base | 23 |
| One staying afloat in place | 27 |
| One step from the majors | 24 |
| One step more than giga- | 24 |
| One step up from extra | 22 |
| One stocking stockings | 22 |
| One stoked to provide warmth | 28 |
| One striking out, maybe | 23 |
| One striving for change? | 24 |
| One stroke more than par | 24 |
| One stroke ___ (bogey) | 22 |
| One struck Chicken Little | 25 |
| One stuck in the kitchen | 24 |
| One studying en français | 27 |
| One subject to a dictator? | 26 |
| One subject to a mortgage | 25 |
| One subject to the Houyhnhnms | 29 |
| One subjected to disarmament? | 29 |
| One successful in tennis | 24 |
| One suffering from hay fever | 28 |
| One suffering from heat | 23 |
| One suit in a tarot deck | 24 |
| One suited to go for a walk? | 28 |
| One summoned by artists | 23 |
| One supported by charity | 24 |
| One supporting a habit? | 23 |
| One supporting a woman | 22 |
| One surrounded by cell walls | 28 |
| One surrounds the Parthenon | 27 |
| One surveying the orchard? | 26 |
| One surviving on chicken feed | 29 |
| One suspended for a game | 24 |
| One suspended in adolescence | 28 |
| One sweep of a hand: Abbr. | 26 |
| One swimming with flippers | 26 |
| One taken by an artist | 22 |
| One taken in by another | 23 |
| One taken on a drive: Abbr. | 27 |
| One taking a bow in Japan | 25 |
| One taking a first step | 23 |
| One taking a long view | 22 |
| One taking a lot of notes | 25 |
| One taking a quick look | 23 |
| One taking applications | 23 |
| One taking defeat graciously | 28 |
| One taking first steps | 22 |
| One taking great interest? | 26 |
| One taking initial steps | 24 |
| One taking off regularly | 24 |
| One taking something forcibly | 29 |
| One taking target practice | 26 |
| One taking tel. messages | 24 |
| One taking the lead?: Abbr. | 27 |
| One taking things badly? | 24 |
| One taking things wrong? | 24 |
| One taking to the slopes | 24 |
| One taking too many courses | 27 |
| One talking impertinently | 25 |
| One tapped for a fraternity | 27 |
| One target of the MMR vaccine | 29 |
| One teaching econ, e.g. | 23 |
| One teaching psych, e.g. | 24 |
| One ten-millionth of a joule | 28 |
| One tending a brush fire? | 25 |
| One term Ontario Premier Bob | 28 |
| One terminus of the GW Bridge | 29 |
| One Thanksgiving trimming | 25 |
| One that brings in the bucks? | 29 |
| One that deals in: Suffix | 25 |
| One that didn't show? | 25 |
| One that doesn't belong | 27 |
| One that eats from bowls | 24 |
| One that eats: Comb. form | 25 |
| One that flies off shelves? | 27 |
| One that gets a leg up? | 23 |
| One that gets hit on the head | 29 |