| First name on compacts | 22 |
| First name on the Mayflower | 27 |
| First name on the moon | 22 |
| First name with The News | 24 |
| First names, in France | 22 |
| First National of Wyoming? | 26 |
| First native-born U.S. saint | 28 |
| First New Testament book | 24 |
| First New World printer | 23 |
| First NHL 2000 point scorer | 27 |
| First Niagara Center NHLer | 26 |
| First Niagara Center player | 27 |
| First nine in a series | 22 |
| First Nobelist in Physics | 25 |
| First noble gas discovered | 26 |
| First note of a tuba solo? | 26 |
| First nuclear-powered sub | 25 |
| First number in a record | 24 |
| First Nunuvut Premier Okalik | 28 |
| First Obi-Wan portrayer | 23 |
| First observed asteroid | 23 |
| First of 12 in South America | 28 |
| First of 12, in Madrid | 22 |
| First of 15 in a table game | 27 |
| First of 66 books: Abbr. | 24 |
| First of a cautionary trio | 26 |
| First of a dead-end trio? | 25 |
| First of a Disney trio | 22 |
| First of a doubleheader | 23 |
| First of a familiar trio | 24 |
| First of a famous trio | 22 |
| First of a hard-partying trio | 29 |
| First of a Hebrew series | 24 |
| First of a Kipling trio | 23 |
| First of a Latin I trio | 23 |
| First of a Latin threesome | 26 |
| First of a literary set | 23 |
| First of a much-quoted trio | 27 |
| First of a musical trio | 23 |
| First of a no-no septet | 23 |
| First of a pair of lists | 24 |
| First of a railway trio | 23 |
| First of a string of 13 | 23 |
| First of a succession of 13 | 27 |
| First of a vowel fivesome? | 26 |
| First of an ancient trio | 24 |
| First of an old film septet | 27 |
| First of Caesar's claims | 28 |
| First of five poker hands | 25 |
| First of four giant syllables | 29 |
| First of Mickey's wives | 27 |
| First of seven (so far) | 23 |
| First of the cardinals | 22 |
| First of the Cavalier poets | 27 |
| First of the eighth century | 27 |
| First of the first pair | 23 |
| First of the five W's | 25 |
| First of the James Bond films | 29 |
| First of the Latter Prophets | 28 |
| First of the Maj. Prophets | 26 |
| First of the Major Prophets | 27 |
| First of the minor prophets | 27 |
| First of three to be put out | 28 |
| First of two baseball games | 27 |
| First of two related lists | 26 |
| First of two sharp turns | 24 |
| First Olympic Games site | 24 |
| First one out in an auto race | 29 |
| First one out on the track | 26 |
| First one to be billed | 22 |
| First one to stab Caesar | 24 |
| First one to ___ (loser) | 24 |
| First one-term president | 24 |
| First one-term U.S. president | 29 |
| First ones are special | 22 |
| First or final cut piece | 24 |
| First or financial follower | 27 |
| First or fore follower | 22 |
| First or foreign follower | 25 |
| First or second, e.g.: Abbr. | 28 |
| First or Second, in N.Y.C. | 26 |
| First or third baseman | 22 |
| First orbiting American | 23 |
| First Oscar-winner Jannings | 27 |
| First Oscar-winning film | 24 |
| First P.M. of modern India | 26 |
| First page of a calendario | 26 |
| First page of el calendario | 27 |
| First page of un calendario | 27 |
| First page on most sites | 24 |
| First part of a Florida city | 28 |
| First part of a musical | 23 |
| First part of a news story | 26 |
| First part of a one-two | 23 |
| First part of a proverb | 23 |
| First part of a question | 24 |
| First part of a record | 22 |
| First part of a riddle | 22 |
| First part of a series | 22 |
| First part of a signature | 25 |