| First century Roman emperor | 27 |
| First cervical vertebra | 23 |
| First chair in the air | 22 |
| First chapter in a primer | 25 |
| First Chief Justice afoot? | 26 |
| First Chief Justice John | 24 |
| First child of 1977-81 | 22 |
| First chimp to orbit Earth | 26 |
| First chips in the center | 25 |
| First chips in the middle | 25 |
| First chips in the pot | 22 |
| First choice, slangily | 22 |
| First Christian martyr | 22 |
| First Christmas travelers? | 26 |
| First Christmas visitors | 24 |
| First CinemaScope film | 22 |
| First CinemaScope movie | 23 |
| First city of Brittany | 22 |
| First Civil War battle site | 27 |
| First claim, informally | 23 |
| First class alternative | 23 |
| First class for painters | 24 |
| First class for some, briefly | 29 |
| First class, for short | 22 |
| First clue in this puzzle | 25 |
| First coed college in U.S. | 26 |
| First colonial printer | 22 |
| First Colony V.I.P.'s | 25 |
| First column bingo call | 23 |
| First Commandment phrase | 24 |
| First commercial computer | 25 |
| First commercial video game | 27 |
| First Congolese P.M. Lumumba | 28 |
| First Constitution section | 26 |
| First couple's home | 23 |
| First couple's place | 24 |
| First course at the prison? | 27 |
| First course of action | 22 |
| First course selection | 22 |
| First course, generally | 23 |
| First course, sometimes | 23 |
| First cousin's mom | 22 |
| First cousins' dads | 23 |
| First created being, in myth | 28 |
| First creature off the ark | 26 |
| First critters on a farm? | 25 |
| First daughter of 1977-81 | 25 |
| First day of a fall mo.? | 24 |
| First day of summer or winter | 29 |
| First digit of current year | 27 |
| First digital computer | 22 |
| First dime novel: Var. | 22 |
| First discovered asteroid | 25 |
| First division of an act | 24 |
| First divorced U.S. president | 29 |
| First Dog of the 1940s | 22 |
| First dog to orbit Earth | 24 |
| First dog walker, maybe | 23 |
| First double-digit number | 25 |
| First drawing class, perhaps | 28 |
| First Dreamliner buyer | 22 |
| First duke of Normandy | 22 |
| First Earl of Beaconsfield | 26 |
| First Earl of Leicester | 23 |
| First edition, usually | 22 |
| First efforts at compromise | 27 |
| First electronic computer | 25 |
| First electronic stock market | 29 |
| First Emmy song hit: 1955 | 25 |
| First Emmy-winning song | 23 |
| First emperor of Austria | 24 |
| First emperor of Brazil | 23 |
| First English globe-girdler | 27 |
| First episode in a TV series | 28 |
| First event in a series | 23 |
| First extra baseball inning | 27 |
| First family as of 2009 | 23 |
| First Family at Albany | 22 |
| First family of Chicago | 23 |
| First Family of early Ferrara | 29 |
| First family of Egypt, once | 27 |
| First family of Ferrara | 23 |
| First family of the 1840s | 25 |
| First family of the 1910s | 25 |
| First family of the 1970s | 25 |
| First Family of the 1980s | 25 |
| First family starting in 2009 | 29 |
| First family's address? | 27 |
| First family's grandson | 27 |
| First family's home | 23 |
| First family's home? | 24 |
| First family's residence | 28 |
| First family's residence? | 29 |
| First family's son | 22 |
| First Family, 1909-1913 | 23 |
| First Family: 1881–85 | 28 |
| First fast-food fancier | 23 |
| First female astronaut | 22 |
| First female attorney general | 29 |
| First female in Parliament | 26 |