| A spire is part of one | 22 |
| A spirit | 8 |
| A spirit raiser? | 16 |
| A spirited steed | 16 |
| A spiritual | 11 |
| A splitting, as of atoms | 24 |
| A sponge may get this | 21 |
| A sponge might have a big one | 29 |
| A spore is at its core | 22 |
| A sport may grab it | 19 |
| A sport of royals | 17 |
| A sport where you can score by using your head | 46 |
| A sports highlight may be seen in it | 36 |
| A sports personality who sounds like a place | 44 |
| A spot | 6 |
| A spot card | 11 |
| A spotted one might be spotted at the zoo | 41 |
| A spouse | 8 |
| A spouse in Sevilla | 19 |
| A spouse may sleep on it after a fight | 38 |
| A spouse, in Savoie | 19 |
| A spray might be used for one | 29 |
| A spread | 8 |
| A sprinkling | 12 |
| A spy may crack it | 18 |
| A spy may use one | 17 |
| A spy might work under one | 26 |
| A spy will often cross them | 27 |
| A spy, perhaps | 14 |
| A sq. is one | 12 |
| A square, Ã la Sinclair Lewis | 32 |
| A square, like Caspar Milquetoast | 33 |
| A squat, e.g. | 13 |
| A stage of man | 14 |
| A stake, metaphorically | 23 |
| A standard shown on a Royal Observatory wall | 44 |
| A standout for sure | 19 |
| A star can have a huge one | 26 |
| A star in "Rebecca": 1940 | 35 |
| A star in "The Miniver Story" | 39 |
| A star in Anaheim | 17 |
| A star in France | 16 |
| A star may have a big one | 25 |
| A star may represent it | 23 |
| A star of The Poseidon Adventure | 35 |
| A star of "Advise and Consent" | 40 |
| A star of "Cats" on Broadway | 38 |
| A star of "Cinderella Liberty" | 40 |
| A star of "Come Back to the 5 & Dime . . . " | 58 |
| A star of "Dr. Strangelove" | 37 |
| A star of "Naughty Marietta" | 38 |
| A star of "Rashomon" and "Ugetsu" | 53 |
| A star of "Seven Days in May" | 39 |
| A star of "She-Devil" | 31 |
| A star of "The Collector" | 35 |
| A star of "The Good Earth" | 36 |
| A star of "The In-Laws" | 33 |
| A star of "Vera Cruz" | 31 |
| A star of "What's Up, Doc?" | 41 |
| A star represents it | 20 |
| A star stands for it | 20 |
| A star stands for it in America | 31 |
| A star stands for it on the flag | 32 |
| A star usually has a big one | 28 |
| A Star ____ | 11 |
| A star's part | 17 |
| A star-ry Knight | 16 |
| A starch source | 15 |
| A stargazer may make one | 24 |
| A Starr | 7 |
| A state | 7 |
| A state capital | 15 |
| A state capital? | 16 |
| A state carved out of Deseret | 29 |
| A state in India | 16 |
| A state in Malaysia | 19 |
| A state named for Sioux Ind. | 28 |
| A state of Brazil | 17 |
| A state of deep-seated ill-will | 31 |
| A state of depression | 21 |
| A state of matter | 17 |
| A state of Mexico | 17 |
| A state of the union address? | 29 |
| A state symbol of Maryland | 26 |
| A state that's hardly solid | 31 |
| A status symbol | 15 |
| A steal | 7 |
| A steam locomotive | 18 |
| A steelworker | 13 |
| A STEIN'S LIQUEUR (anag.) | 29 |
| A step below so-so | 18 |
| A step below the Majors | 23 |
| A step between floors | 21 |
| A step from | 11 |
| A step up | 9 |
| A step up, maybe? | 17 |
| A step up? | 10 |
| A stereotypical pirate only has one | 35 |
| A stern chaser is one | 21 |
| A Stern fellow | 14 |