| Only member of both OPEC and the British Commonwealth | 53 |
| Only man to win two tennis Grand Slams | 38 |
| Only man to win both a Nobel Prize and an Oscar | 47 |
| Only man to twice win the U.S. Open without losing a set in the entire tournament | 81 |
| Only man to fly in Mercury, Gemini and Apollo missions | 54 |
| Only man to be U.S. President and Chief Justice | 47 |
| Only man ever to win an L.P.G.A. Tour tournament (1962) | 55 |
| Only mammal with horns made of keratin | 38 |
| Only male singles Career Golden Slam winner | 43 |
| Only making the grade? | 22 |
| Only make-believe | 17 |
| Only major U.S. city with a radio station whose call letters spell the city's name | 86 |
| Only major tourney that Sam Snead failed to win | 47 |
| Only major "MASH" character played by the same actor in the film and TV series | 88 |
| Only look | 9 |
| Only Literature Nobelist also to win an Oscar | 45 |
| Only last name shared by two different Best Actor Oscar winners | 63 |
| Only key Irving Berlin composed in | 34 |
| Only just managed, with "out" | 39 |
| Only just managed (with "out") | 40 |
| Only just broke the tape | 24 |
| Only just | 9 |
| Only Japanese MLB player to pitch a no-hitter (he had two) | 58 |
| Only insects that can turn their heads to look behind them | 58 |
| Only Indonesian-speaking President | 34 |
| Only inanimate zodiac sign | 26 |
| Only inanimate zodiac representation | 36 |
| Only in the past | 16 |
| Only if it's worth the trade-off | 36 |
| Only hypothetical | 17 |
| Only host country to win the Women's World Cup | 50 |
| Only horse to defeat Man o' War | 35 |
| Only horse to beat Man o' War | 33 |
| Only Hitchcock film to win Best Picture | 39 |
| Only Hitchcock film to get a Best Picture Oscar | 47 |
| Only hit song for which title and artist are both palindromes | 61 |
| Only Hispanic performer with an Emmy, Grammy, Oscar and Tony | 60 |
| Only highest grossing film of the year to run at a loss | 55 |
| Only head coach in six Super Bowls | 34 |
| Only have eyes for | 18 |
| Only half | 9 |
| Only good part of a bad movie? | 30 |
| Only God can make one, according to Kilmer | 42 |
| Only ghost not mentioned by name in "Pac-Man Fever" | 61 |
| Only four-letter Great Lake | 27 |
| Only founding member of OPEC not located in the Mideast | 55 |
| Only form that carbohydrates take? | 34 |
| Only five-time U.S. Horse of the Year | 37 |
| Only film to sweep the major categories at the Golden Raspberries | 65 |
| Only film of its series directed by William Shatner | 51 |
| Only female to have received jazz, pop, and classical music Grammy nominations | 78 |
| Only female character in a classic 1926 book | 44 |
| Only female attorney general | 28 |
| Only female Argonaut, per some sources | 38 |
| Only fair, or an alternative title for this puzzle? | 51 |
| Only fair | 9 |
| Only externally visible part of the central nervous system | 58 |
| Only ex-wife of a U.S. president | 32 |
| Only event in which Venezuela medaled at the 2012 Olympics | 58 |
| Only even prime number | 22 |
| Only Englishman to head the Vatican | 35 |
| Only Englishman to become pope (1154) | 37 |
| Only Englishman named a Dr. of the Church | 41 |
| Only Englishman buried in Arlington | 35 |
| Only Dolphin quarterback to win a Super Bowl | 44 |
| Only defenseman to lead the NHL in scoring | 42 |
| Only defenseman in NHL history to have won the scoring title | 60 |
| Only deer in which both sexes have antlers | 42 |
| Only daughter of Queen Elizabeth II and Prince Philip | 53 |
| Only daughter of Elizabeth II | 29 |
| Only crime defined in the Constitution | 38 |
| Only creature that blushes | 26 |
| Only country without a rectangular flag | 39 |
| Only country with a non-rectangular flag | 40 |
| Only country whose capital starts with "Q": Abbr. | 59 |
| Only companion | 14 |
| Only common word in the English language with the consecutive letters MPG | 73 |
| Only common English word from the Finnish | 41 |
| Only coach to win both N.F.L. and A.F.L. championships | 54 |
| Only child's lack | 21 |
| Only Chief Justice to have a state funeral | 42 |
| Only chess move in which two pieces move on the same turn | 57 |
| Only character who appeared in every episode of "Star Trek" | 69 |
| Only character mentioned in the "Star Wars" crawl | 59 |
| Only Central American nation whose official language is English | 63 |
| Only cardinal point not in a U.S. state name | 44 |
| Only Canadian PM with message on the moon | 41 |
| Only Canadian MLB team | 22 |
| Only Canadian major league team, on scoreboards | 47 |
| Only brother not in any Marx Brothers films | 43 |
| Only British prime minister of Jewish birth | 43 |
| Only black child in "South Park" | 42 |
| Only bird with nostrils on the tip of its beak | 46 |
| Only Billboard hit for the Spanish group Mocedades | 50 |
| Only Bible book that doesn't mention God | 44 |
| Only Best Director Oscar/Tony/Emmy winner in the same year | 58 |
| Only Belarus city with an underground metro | 43 |
| Only Beatle who never appeared on "Saturday Night Live" | 65 |
| Only beardless one of the Seven Dwarfs | 38 |
| Only beardless Disney dwarf | 27 |