| It's close but gets no cigar | 32 |
| It's close to home/Broker order | 35 |
| It's close to one's goal in football | 44 |
| It's closed by the epiglottis | 33 |
| It's closest to the foul line | 33 |
| It's cold, regardless of climate | 36 |
| It's collected on a turnpike | 32 |
| It's coming here slowly but surely | 38 |
| It's common in grammar class | 32 |
| It's commonly paired with prosciutto | 40 |
| It's composed of three quarks | 33 |
| It's comprised of ages and ages | 35 |
| It's concerned with Hg emissions | 36 |
| It's connected to a handlebar | 33 |
| It's connected to the Eustachian tube | 41 |
| It's connected to the Gulf of Aden | 38 |
| It's connected to the humerus | 33 |
| It's connected to the left ventricle | 40 |
| It's connected to this puzzle's theme | 45 |
| It's considerably bigger than D | 35 |
| It's considered "a virtue" | 40 |
| It's covered with red paraffin wax | 38 |
| It's created to prevent data loss | 37 |
| It's crossed by a center line | 33 |
| It's crumbled on Greek salad | 32 |
| It's cultivated by indie labels | 35 |
| It's cultivated in the Andes | 32 |
| It's cupped to catch a whisper | 34 |
| It's cured but was never sick | 33 |
| It's cut in pursuit of a break | 34 |
| It's dangerous for you to fly by | 36 |
| It's dangerous if it strikes | 32 |
| It's dangerous to be behind them | 36 |
| It's dangerous to be on this | 32 |
| It's dangerous to do on the road | 36 |
| It's dangerous to do while driving | 38 |
| It's de rigueur for a diplomat | 34 |
| It's decisively important to a solution | 43 |
| It's declared after the last hit, for short | 47 |
| It's definitely a reserved seat | 35 |
| It's definitely not the short answer | 40 |
| It's delivered on the gridiron | 34 |
| It's delivered to millions on Sundays | 41 |
| It's delivered underhandedly? | 33 |
| It's demonstrated by ring color | 35 |
| It's depicted on the Sistine Chapel ceiling | 47 |
| It's deposited when glacial ice melts | 41 |
| It's derived from natural gas | 33 |
| It's designed for quick entrances | 37 |
| It's designed not to be noticeable | 38 |
| It's designed to come back to you | 37 |
| It's designed to give you a lift | 36 |
| It's detected by the Marsh test, in forensics | 49 |
| It's developed during training season | 41 |
| It's dialed before a long-distance number | 45 |
| It's difficult to find in a haystack | 40 |
| It's difficult to see through | 33 |
| It's directly behind the three | 34 |
| It's disagreeable to the nose | 33 |
| It's disproved with Zener cards | 35 |
| It's disregarded in alphabetizing | 37 |
| It's dissolved into a solvent | 33 |
| It's distilled from fermented molasses, often | 49 |
| It's done at psychedelic shows | 34 |
| It's done for appearance' sake | 38 |
| It's done for fun, for short | 32 |
| It's done in France all the time | 36 |
| It's done in the form of an S or a Z | 40 |
| It's done in the shape of an S or Z | 39 |
| It's done while holding hands | 33 |
| It's double-hyphenated: Abbr. | 33 |
| It's down the coast from Portland | 37 |
| It's down, in a Homestar Runner cartoon | 43 |
| It's drawn between similar things | 37 |
| It's drawn to explain differences | 37 |
| It's Dreyer's west of the Rockies | 41 |
| It's dried and salted to make bacalao | 41 |
| It's drilled during Tommy John surgery | 42 |
| It's driven over the ice between periods | 44 |
| It's dropped after a bomb is dropped | 40 |
| It's dropped before tripping | 32 |
| It's dropped for a trip, to a pilot | 39 |
| It's dropped to start a trip | 32 |
| It's dry in "American Pie" | 40 |
| It's due north of Pittsburgh | 32 |
| It's due west of Daytona Beach | 34 |
| It's due when it's doubled | 34 |
| It's earned for bringing someone home: Abbr. | 48 |
| It's earned on the street, briefly | 38 |
| It's east of the Bering Strait | 34 |
| It's east of the Great Barrier Reef | 39 |
| It's east of the Isle of Man: Abbr. | 39 |
| It's easy to get down from them | 35 |
| It's eaten in Eastern Europe | 32 |
| It's educational, according to The Pixies | 45 |
| It's effective only when fired | 34 |
| It's effective when it gets in hot water | 44 |
| It's eight hours later than PST | 35 |
| It's eight hrs. later than PST | 34 |
| It's either positive or negative | 36 |