| First known variable star | 25 |
| First knuckleballer to win the Cy Young | 39 |
| First Korean president | 22 |
| First Labor P.M. to win consecutive terms | 41 |
| First lady | 10 |
| First lady after Bess | 21 |
| First lady after Eleanor | 24 |
| First lady after Hillary | 24 |
| First Lady after Lady Bird | 26 |
| First lady after Lou | 20 |
| First lady and diplomat Roosevelt | 33 |
| First lady before Abigail | 25 |
| First lady before Eleanor | 25 |
| First lady before Jackie | 24 |
| First lady before Mamie | 23 |
| First lady before Michelle | 26 |
| First lady between Bess and Jackie | 34 |
| First lady between Eleanor and Mamie | 36 |
| First lady between Frances and Edith | 36 |
| First lady between Lou and Bess | 31 |
| First lady Bush | 15 |
| First Lady Claudia ___ Johnson | 30 |
| First lady dubbed "Spiritual Leader of the Nation" | 60 |
| First lady Eisenhower | 21 |
| First Lady for 13 years | 23 |
| First Lady Ford | 15 |
| First lady from 1946 to 1952 | 28 |
| First lady Gorbacheva | 21 |
| First Lady Grace's man | 26 |
| First lady Harrison | 19 |
| First lady in 1900 | 18 |
| First Lady in 1929 | 18 |
| First lady in Parliament | 24 |
| First Lady Lou Hoover, ___ Henry | 32 |
| First Lady Madison | 18 |
| First lady McKinley | 19 |
| First Lady of 1900 | 18 |
| First Lady of California | 24 |
| First Lady of Jazz | 18 |
| First lady of Jewish folklore | 29 |
| First lady of Leeds | 19 |
| First Lady of Mount Olympus | 27 |
| First Lady of Olympus | 21 |
| First lady of scat | 18 |
| First lady of scat, familiarly | 30 |
| First lady of song | 18 |
| First Lady of Song Fitzgerald | 29 |
| First lady of the 1910s | 23 |
| First Lady of the 1940s | 23 |
| First lady of the 1950s | 23 |
| First lady of the 1980s | 23 |
| First Lady of the 40's | 26 |
| First lady of the United States (1861-1865) | 43 |
| First lady of the United States (1953-1961) | 43 |
| First lady of the United States (1963-1969) | 43 |
| First lady on Mount Olympus | 27 |
| First lady on Mt. Olympus | 25 |
| First lady on Olympus | 21 |
| First lady played by Madonna | 28 |
| First lady Truman | 17 |
| First lady who was once a prominent radio actress | 49 |
| First Lady who went to Harvard Law School | 41 |
| First lady who wrote "Millie's Book" | 50 |
| First Lady whose maiden name was Duarte | 39 |
| First lady with bangs | 21 |
| First lady ___ McKinley | 23 |
| First Lady's designation | 28 |
| First Lady's first name | 27 |
| First lady's garden | 23 |
| First lady's garden site? | 29 |
| First lady's home | 21 |
| First lady's home? | 22 |
| First lady's hype? | 22 |
| First lady's man | 20 |
| First lady's man? | 21 |
| First lady's mate? | 22 |
| First lady's namesakes | 26 |
| First lady's residence | 26 |
| First lady's residence? | 27 |
| First Lady's title | 22 |
| First lady, May 7, 1988? | 24 |
| First lady, no kidding | 22 |
| First Lady, often | 17 |
| First lady/pop star Carla | 25 |
| First Lady: 1929 | 16 |
| First lady? | 11 |
| First landfall north of Oman | 28 |
| First language of Hank's neighbor on "King of the Hill" | 69 |
| First last name tag | 19 |
| First Latin American country to nationally legalize same-sex civil unions | 73 |
| First Latin American Olympics host | 34 |
| First Latina nominated for the Supreme Court | 44 |
| First law of motion subject | 27 |
| First layer of furniture protection | 35 |
| First layer of plaster | 22 |
| First lesson, maybe | 19 |
| First lessons | 13 |
| First letter | 12 |
| First letter for the head of Centauri? | 38 |
| First letter given to Odysseus | 30 |