| Drug info | 9 |
| Drug initially studied for use in treating angina | 49 |
| Drug initials | 13 |
| Drug introduced commercially in 1945 | 36 |
| Drug kingpin | 12 |
| Drug like diazepam | 18 |
| Drug list: Abbr. | 16 |
| Drug lord Escobar | 17 |
| Drug made from dried roots | 26 |
| Drug made from orchids | 22 |
| Drug made from poppies | 22 |
| Drug made in labs | 17 |
| Drug magnate Lilly | 18 |
| Drug measure | 12 |
| Drug mogul Lilly | 16 |
| Drug money? | 11 |
| Drug of forgetfulness | 21 |
| Drug offense recidivist | 23 |
| Drug officer, for short | 23 |
| Drug often advertised in e-mail spam | 36 |
| Drug on blotter paper | 21 |
| Drug once available under the commercial name Delysid | 53 |
| Drug once derived from willow bark | 34 |
| Drug once smoked in dens | 24 |
| Drug once tested extensively by CIA employees | 45 |
| Drug or DNA home-use set | 24 |
| Drug or heartwood | 17 |
| Drug paraphernalia for those who aren't sure they want to go through with it? | 81 |
| Drug plant | 10 |
| Drug plants | 11 |
| Drug portion | 12 |
| Drug prefix | 11 |
| Drug problem | 12 |
| Drug program on bumpers | 23 |
| Drug pusher's enemy | 23 |
| Drug quantity | 13 |
| Drug quantity, sometimes | 24 |
| Drug raids | 10 |
| Drug rehab process | 18 |
| Drug retailing org. | 19 |
| Drug ring buster | 16 |
| Drug ring busters | 17 |
| Drug ring cops | 14 |
| Drug ring ringers | 17 |
| Drug safety test | 16 |
| Drug served in a den | 20 |
| Drug shipment, maybe | 20 |
| Drug shipment, perhaps | 22 |
| Drug smuggler | 13 |
| Drug smuggler's courier | 27 |
| Drug smuggler's measures, perhaps | 37 |
| Drug smugglers | 14 |
| Drug sold as Marinol [Subscribe to weekly indie xwords at avxwords.com] | 71 |
| Drug sold in microdots | 22 |
| Drug sold on blotting paper | 27 |
| Drug sold under the brand name Retrovir | 39 |
| Drug source | 11 |
| Drug source for ancient executions | 34 |
| Drug source [right only] | 24 |
| Drug squad member | 17 |
| Drug squad members | 18 |
| Drug squad, for short | 21 |
| Drug store? | 11 |
| Drug study data | 15 |
| Drug supplier | 13 |
| Drug taken by Timothy Leary | 27 |
| Drug taken in "Rent" | 30 |
| Drug taken mostly by kids | 25 |
| Drug tested on U.S. citizens by the CIA in the 1950s | 52 |
| Drug tester's control substance | 35 |
| Drug that calms the nerves, slangily | 36 |
| Drug that can cause an acid trip | 32 |
| Drug that can cause flashbacks | 30 |
| Drug that can cause memory blackouts, in slang | 46 |
| Drug that causes tripping | 25 |
| Drug that dulls the brain | 25 |
| Drug that goes up your nose | 27 |
| Drug that is, ironically, inhaled | 33 |
| Drug that keeps you going? | 26 |
| Drug that may be taken in tea | 29 |
| Drug that may keep you up for days? | 35 |
| Drug that might cause flashbacks | 32 |
| Drug that promotes male growth | 30 |
| Drug that reduces excitability | 30 |
| Drug that relieves pain | 23 |
| Drug that treats panic attacks | 30 |
| Drug that was dropped in the '60s | 37 |
| Drug that's a downer | 24 |
| Drug that's affiliated with anxietyinfo.com | 47 |
| Drug that's breatheD | 24 |
| Drug that's central to William Shatner's sci-fi series | 62 |
| Drug that's dropped | 23 |
| Drug that's only smoked in pictures? | 40 |
| Drug that's smoked in a pipe | 32 |
| Drug to treat Parkinson's disease | 37 |
| Drug traffickers | 16 |
| Drug treating parkinsonism | 26 |
| Drug treatment | 14 |
| Drug trial staple | 17 |
| Drug unit | 9 |