| Oliver Hazard Perry victory site | 32 |
| Northwesternmost Pennsylvania county | 36 |
| Northwesternmost county in Pennsylvania | 39 |
| Northwestern Pennsylvania county | 32 |
| New York's shortest-named county | 36 |
| New York's most populous upstate county | 43 |
| New York tribe defeated by the Iroquois | 39 |
| New York and ___ Railroad, started in 1832 | 42 |
| Most populous county in upstate New York | 40 |
| Most of Ohio's northern boundary | 36 |
| Mercyhurst University's city | 32 |
| Lake where Perry prevailed in 1813 | 34 |
| Lake where Perry achieved an 1813 victory | 41 |
| Lake visible from the Rock and Roll Hall of Fame | 48 |
| Lake visible from Cedar Point amusement park | 44 |
| Lake that's the outlet for the Detroit River | 48 |
| Lake that touches New York and Ontario | 38 |
| Lake that Ohio's Lake County borders | 40 |
| Lake that flows into the Niagara River | 38 |
| Lake site of a War of 1812 battle | 33 |
| Lake on the U.S.-Canadian boundary | 34 |
| Lake on four states and a province | 34 |
| Lake next to Cedar Point amusement park | 39 |
| Lake into which Ohio's Cuyahoga River empties | 49 |
| Lake from which the Niagara River flows | 39 |
| Lake depicted on Michigan's state quarter | 45 |
| Lake by the Rock and Roll Hall of Fame | 38 |
| Lake at southernmost point of Canada | 36 |
| Lake adjacent to the Rock and Roll Hall of Fame | 47 |
| Lake ___, source of the Niagara River | 37 |
| Lake ___, home of the Bass Islands | 34 |
| Lake ___, discovery of Louis Jolliet | 36 |
| Lackawanna's railroad partner | 33 |
| Lackawanna's partner in railroads | 37 |
| Lackawanna's partner in railroading | 39 |
| Jay Gould's railroad: 1867–72 | 40 |
| It's part of four states' borders | 41 |
| It's due north of Pittsburgh | 32 |
| It's between Huron and Ontario | 34 |
| It's about 115 miles north of Pittsburgh | 44 |
| Indian of the Great Lakes region | 32 |
| Home port of the U.S. brig Niagara | 34 |
| Home of the reconstructed USS Niagara | 37 |
| Home of the Freeze indoor football team | 39 |
| Home of Presque Isle Downs racetrack | 36 |
| His name means "long tail" | 36 |
| Great Lakes / Atlantic Ocean link | 33 |
| Great Lake bordering Pennsylvania | 33 |
| Great Lake between Huron and Ontario | 36 |
| Fort ___, captured by U.S. forces in 1814 | 41 |
| First Great Lake, alphabetically | 32 |
| Famous canal in the Ramones' home state | 43 |
| Eastern tribe overcome by the Iroquois | 38 |
| Discovery some attribute to Jolliet | 35 |
| De Witt Clinton's "ditch" | 39 |
| County in Pennsylvania or New York | 34 |
| County in New York, Ohio or Pennsylvania | 40 |
| County in both Pennsylvania and New York | 40 |
| Commodore Perry's victory site | 34 |
| City where most of Perry's ships were built | 47 |
| City that's home to the U.S. Brig Niagara | 45 |
| City of 100,000+ or the lake it's on | 40 |
| City in the minors' Eastern League | 38 |
| City between Cleveland and Buffalo | 34 |
| City between Buffalo and Cleveland | 34 |
| City across the state from Philadelphia | 39 |
| Canal that originally had 83 locks | 34 |
| Canal that needed Clinton's clout | 37 |
| Canal that cost $7,143,789 to build | 35 |
| Canal in the Ramones' home state | 36 |
| Canal from the Great Lakes to the Atlantic Ocean | 48 |
| Canal from the Great Lakes to the Atlantic | 42 |
| Canal depicted on New York's state quarter | 46 |
| Canal called "Clinton's Folly" | 44 |
| Canada's Battle of Fort ___, 1866 | 37 |
| A body on Canada's southern border | 38 |
| 15 miles of it are mentioned in a song | 38 |
| "We have met the enemy" there | 39 |
| "Walleye Capital of the World" | 40 |
| "that thing you do!" setting | 38 |
| "Low bridge! Everyone down!" canal | 44 |
| "Lake effect snow" city | 33 |
| "15 miles on the ___ Canal" | 37 |
| ''Clinton's Ditch'' | 39 |
| ___ quenelle (Pa. poached dumpling?) | 36 |
| ___ Lackawanna (bygone railroad) | 32 |
| ___ Canal, waterway through Schenectady | 39 |
| Work on it began in Rome in 1817 | 32 |
| Waterway that's 363 miles long | 34 |
| Line on New York's state quarter | 36 |
| Early 19th-century engineering marvel | 37 |
| De Witt Clinton's pet project | 33 |
| Construction project that began in Rome | 39 |
| Clinton had a big role in its construction | 42 |
| 363-mile project known as Clinton's Folly | 45 |
| Part of a postal address for Gannon University | 46 |
| Part of a postal address for Gannon Univ. | 41 |
| Line on a letter to Presque Isle Bay | 36 |
| Home of Perry's "USS Niagara" | 43 |
| City down the lake from Buffalo, N.Y. | 37 |