| Like the Sabbath | 16 |
| Like the Sabin polio vaccine | 28 |
| Like the Sabin vaccine | 22 |
| Like the safest corporate investments | 37 |
| Like the Sahara | 15 |
| Like the Sahara's climate | 29 |
| Like the Sahel | 14 |
| Like the samba and salsa | 24 |
| Like the SAT and GRE | 20 |
| Like the SATs | 13 |
| Like the scent of many cleaners | 31 |
| Like the scent of many tree-shaped air fresheners | 49 |
| Like the scent of pines, perhaps | 32 |
| Like the scholarly world | 24 |
| Like the Scion xB | 17 |
| Like the score at the start of the 10th inning | 46 |
| Like the score for the first play of a Scrabble game | 52 |
| Like the Scottish burr | 22 |
| Like the scriptures on which Hare Krishna is based | 50 |
| Like the scrub jay | 18 |
| Like the sea | 12 |
| Like the sea lion | 17 |
| Like the Sea of Tranquility | 27 |
| Like the seafood in sushi | 25 |
| Like the seafood in sushi, often | 32 |
| Like the season before Easter | 29 |
| Like the service academies | 26 |
| Like the set Ø | 17 |
| Like the setting of "Green Acres" | 43 |
| Like the seven-year itch? | 25 |
| Like the seventh series game | 28 |
| Like the Shadow | 15 |
| Like the Shenandoah Valley | 26 |
| Like the Sherpas | 16 |
| Like the shore, often | 21 |
| Like the shortest plays | 23 |
| Like the simplest process | 25 |
| Like the Simpson kids' hair | 31 |
| Like the Sinai | 14 |
| Like the Sinai Peninsula | 24 |
| Like the Sinai's el Tih | 27 |
| Like the six longest answers in this puzzle | 43 |
| Like the Six Million Dollar Man | 31 |
| Like the size of a small farm | 29 |
| Like the skies in "Ulalume" | 37 |
| Like the skies in Bob Dylan's "Mozambique" | 56 |
| Like the skin of fish and reptiles | 34 |
| Like the sky | 12 |
| Like the sky at dawn or sunset | 30 |
| Like the sky during fireworks | 29 |
| Like the sky just after sunset | 30 |
| Like the sky over Paris, at times | 33 |
| Like the slalom | 15 |
| Like the slickest city slicker | 30 |
| Like the smallest bands | 23 |
| Like the smallest kind of garage | 32 |
| Like the smallest of the litter | 31 |
| Like the Smashing Pumpkins' rat | 35 |
| Like the smell of a cheap tavern | 32 |
| Like the smell of a keg party | 29 |
| Like the smell of burning rubber | 32 |
| Like the smell of dough | 23 |
| Like the smell of fresh pine | 28 |
| Like the smell of soil | 22 |
| Like the smell of success | 25 |
| Like the Smoky Mountains | 24 |
| Like the snow in a shaken snow globe | 36 |
| Like the snowy owl | 18 |
| Like the sober man who remained? | 32 |
| Like the SoHo crowd | 19 |
| Like the sole of a Desert Boot | 30 |
| Like the son in a Biblical parable | 34 |
| Like the son in a parable of Jesus | 34 |
| Like the sordid side of life | 28 |
| Like the soul, to some believers | 32 |
| Like the souls of T. S. Eliot's housemaids | 46 |
| Like the sound "ng" | 29 |
| Like the sound "tsk" | 30 |
| Like the sound holes of a cello | 31 |
| Like the sound of a gong | 24 |
| Like the sound of a teakettle | 29 |
| Like the sound of a theremin | 28 |
| Like the sound of bagpipes | 26 |
| Like the sound of French vowels | 31 |
| Like the sound of oboes | 23 |
| Like the Souphanousinphone family on "King of the Hill" | 65 |
| Like the Sp. "el" | 27 |
| Like the space around a first-class seat, say | 45 |
| Like the Span. armada? | 22 |
| Like the Spanish Sahara | 23 |
| Like the speech of a person with a cold | 39 |
| Like the speed of light | 23 |
| Like the spelling of oyster-abstaining months | 45 |
| Like the Sphynx cat | 19 |
| Like the spire of Manhattan's Chrysler Building | 51 |
| Like the sport of jai alai | 26 |
| Like the spotted owl | 20 |
| Like the square root of 2: Abbr. | 32 |
| Like the SST fleet: Abbr. | 25 |
| Like the stables cleaned by Hercules | 36 |