| Two-inch nail | 13 |
| Two-in-one creatures? | 21 |
| Two-in-one | 10 |
| Two-humped camel | 16 |
| Two-hulled vessel, for short | 28 |
| Two-hulled craft | 16 |
| Two-hued sea predator | 21 |
| Two-hr. warning for Cinderella? | 31 |
| Two-horse wager | 15 |
| Two-horse bet | 13 |
| Two-holed feature | 17 |
| Two-headed, three-armed President in the books referenced in this puzzle's theme | 84 |
| Two-headed lady exhibit, e.g. | 29 |
| Two-headed fastener | 19 |
| Two-headed drumsticks | 21 |
| Two-headed calf, for one | 24 |
| Two-hanky film | 14 |
| Two-handled Greek vase | 22 |
| Two-handled cooking vessels | 27 |
| Two-handed sandwich | 19 |
| Two-handed pinochle | 19 |
| Two-handed lunches | 18 |
| Two-handed lunch orders | 23 |
| Two-handed log cutter | 21 |
| Two-handed hoop attempts | 24 |
| Two-handed hammer | 17 |
| Two-handed gesture used for ironic effect | 41 |
| Two-handed game | 15 |
| Two-handed carpenter's tool | 31 |
| Two-handed card game | 20 |
| Two-grade system | 16 |
| Two-generation name in Indiana politics | 39 |
| Two-generation MLB family name | 30 |
| Two-generation groups | 21 |
| Two-generation diamond name | 27 |
| Two-front, as a Coast Guard rescue | 34 |
| Two-for-one? | 12 |
| Two-for-one, for one | 20 |
| Two-for-one, e.g. | 17 |
| Two-for-one event | 17 |
| Two-for-one deal, say | 21 |
| Two-for-one at a leading dating site? | 37 |
| Two-footers | 11 |
| Two-footer? | 11 |
| Two-footer | 10 |
| Two-footed ones | 15 |
| Two-footed livestock | 20 |
| Two-footed creatures | 20 |
| Two-footed creature | 19 |
| Two-footed animal | 17 |
| Two-footed | 10 |
| Two-foot verse | 14 |
| Two-fold | 8 |
| Two-floor apartment | 19 |
| Two-flat key | 12 |
| Two-fisted sandwich | 19 |
| Two-fisted one | 14 |
| Two-fisted lunch | 16 |
| Two-fisted fellows | 18 |
| Two-fisted | 10 |
| Two-finger sign | 15 |
| Two-finger salute | 17 |
| Two-finger gesture | 18 |
| Two-film show | 13 |
| Two-figure sculpture | 20 |
| Two-fifths of the count | 23 |
| Two-fifths of one quarter? | 26 |
| Two-fifths of one quarter | 25 |
| Two-fifths of MV | 16 |
| Two-fifths of DV | 16 |
| Two-fifths of CXL | 17 |
| Two-fifths of 'N Sync? | 26 |
| Two-fifteenths of CDXX | 22 |
| Two-fifteenths of CCCXC | 23 |
| Two-fer coupon acronym | 22 |
| Two-family house | 16 |
| Two-faced? | 10 |
| Two-faced Roman god | 19 |
| Two-faced person? | 17 |
| Two-faced god | 13 |
| Two-faced gatekeeper | 20 |
| Two-faced fieldwork | 19 |
| Two-faced deity's period | 28 |
| Two-faced deity | 15 |
| Two-faced | 9 |
| Two-Face's alter ego, in the "Batman" series | 58 |
| Two-Face and the Riddler, to Batman | 35 |
| Two-eyelet shoe | 15 |
| Two-event events | 16 |
| Two-element tube | 16 |
| Two-element electron tube | 25 |
| Two-electrode tube | 18 |
| Two-edged wager | 15 |
| Two-edged swords | 16 |
| Two-edged sword | 15 |
| Two-eared | 9 |
| Two-dot punctuation | 19 |
| Two-dot mark | 12 |
| Two-dot diacritics | 18 |
| Two-dot diacritical marks | 25 |