| First in a series | 17 |
| First in a popular horror movie franchise | 41 |
| First in a pair | 15 |
| First in a multi-volume set | 27 |
| First in a long line? | 21 |
| First in a long line of sitcoms? | 32 |
| First in a line of Russian grand princes | 40 |
| First in a line of cars | 23 |
| First in a line of 260+ | 23 |
| First in a John Updike novel series | 35 |
| First in a horror film franchise | 32 |
| First in a historical trio | 26 |
| First in a classical sequence | 29 |
| First in a car, say | 19 |
| First in a (non-contiguous) series of thirteen popes | 52 |
| First impeached U.S. president | 30 |
| First husband? | 14 |
| First husband of Bathsheba | 26 |
| First husband | 13 |
| First human to orbit the Earth | 30 |
| First human to die | 18 |
| First human in space | 20 |
| First human born, according to the Bible | 40 |
| First houseboat | 15 |
| First host of "The Family Feud" | 41 |
| First host of "Jeopardy!" | 35 |
| First host of "America's Got Talent" | 50 |
| First host of "America's Funniest Home Videos" | 60 |
| First host of ''How to Boil Water'' | 51 |
| First horse to win the Triple Crown | 35 |
| First horse to compete in all three Triple Crown races | 54 |
| First Honorary Reagan Fellow of Eureka College | 46 |
| First homicide victim | 21 |
| First home? | 11 |
| First home of the University of Nevada | 38 |
| First home | 10 |
| First Holy Roman emperor | 24 |
| First hole in the head? | 23 |
| First holder of the title Supreme Governor of the Church of England | 67 |
| First hockey player to win Sports Illustrated's Sportsman of the Year | 73 |
| First hit for Zhané | 22 |
| First hit for the Police | 24 |
| First hit for The Moody Blues | 29 |
| First hit for The 4 Seasons | 27 |
| First hit for Otis Redding | 26 |
| First hit by the Police, 1979 | 29 |
| First hit by Rodgers-Hart | 25 |
| First hip-hop single to reach #1 on the Billboard charts | 56 |
| First high priest of the Hebrews | 32 |
| First Hebrew patriarch (Var.) | 29 |
| First Hebrew patriarch | 22 |
| First Hebrew month | 18 |
| First Hebrew letter: Var. | 25 |
| First Hebrew letter, in some transliterations | 45 |
| First Hebrew letter (var.) | 26 |
| First Hebrew letter | 19 |
| First Hebrew calendar month | 27 |
| First heavyweight champ | 23 |
| First hard rock band to score a #1 country hit | 46 |
| First Hannibal Lecter novel | 27 |
| First half of things we all memorized | 37 |
| First half of the files? | 24 |
| First half of the alphabet | 26 |
| First half of CLUE #2 | 21 |
| First half of an LP | 19 |
| First half of an Iowa city | 26 |
| First half of an inning | 23 |
| First half of an indirect course? | 33 |
| First half of an ice cream flavor | 33 |
| First half of an exploring duo | 30 |
| First half of an attention-getter | 33 |
| First half of an album | 22 |
| First half of a workout mantra | 30 |
| First half of a Senate vote | 27 |
| First half of a secret language on "Zoom" | 51 |
| First half of a Samoan city | 27 |
| First half of a quote | 21 |
| First half of a lose-lose comment | 33 |
| First half of a Little Richard song title | 41 |
| First half of a famous Park Avenue hotel name | 45 |
| First half of a cassette | 24 |
| First half of a Beatles song title | 34 |
| First half | 10 |
| First hair remover to be marketed in cream form | 47 |
| First H.E.W. Secretary ___ Culp Hobby | 37 |
| First guy on the moon | 21 |
| First group to get invites | 26 |
| First group to get invitations | 30 |
| First group to be invited | 25 |
| First group of invitees | 23 |
| First group in a product run | 28 |
| First group chosen | 18 |
| First Greek-American vice president | 35 |
| First Greek vowel | 17 |
| First Greek letters | 19 |
| First Greek letter, to El Greco | 31 |
| First Greek letter | 18 |
| First Greek consonant | 21 |
| First great master of the symphony | 34 |
| First Great Lake, alphabetically | 32 |