| American ___ (century plant) | 28 |
| American ___ | 12 |
| American __: Pacific territory | 30 |
| American __, North Dakota state tree | 36 |
| American __, Massachusetts state tree | 37 |
| American __ (veterans' group) | 33 |
| American __ | 11 |
| American writer Plath | 21 |
| American writer Bret | 20 |
| American writer | 15 |
| American worker? | 16 |
| American worker | 15 |
| American with Japanese parents | 30 |
| American with Japanese immigrant parents | 40 |
| American with a crown | 21 |
| American with a British accent | 30 |
| American wildcats | 17 |
| American wildcat | 16 |
| American whiskies | 17 |
| American web site info | 22 |
| American way? | 13 |
| American watercolorist | 22 |
| American watcher, for short | 27 |
| American warbler | 16 |
| American wapitis | 16 |
| American vulture | 16 |
| American voters before 1920 | 27 |
| American vodka brand | 20 |
| American visiting the Eiffel Tower, e.g. | 40 |
| American violinist | 18 |
| American violet [right hand] | 28 |
| American vintner | 16 |
| American university where Desmond Tutu taught theology | 54 |
| American University locale | 26 |
| American uncle | 14 |
| American turtle | 15 |
| American trumpet player Armstrong | 33 |
| American tribe that lent its name to a state | 44 |
| American tribe | 14 |
| American trial lawyer | 21 |
| American trees | 14 |
| American travel expense | 23 |
| American trailing plant | 23 |
| American toy introduced in 1945 | 31 |
| American thrush | 15 |
| American Theatre Wing award | 27 |
| American theater for six years as of March 20, 2009 | 51 |
| American territory in the Pacific | 33 |
| American territory | 18 |
| American tennis star | 20 |
| American tennis icon Arthur | 27 |
| American taxpayer's ID | 26 |
| American symbols that stand out? | 32 |
| American symbol | 15 |
| American swimmer whose relay team set a world record in the women's 4×100 freestyle at the 1924 Olympics | 112 |
| American suffragist honored with a 1995 stamp | 45 |
| American suffragist and reformer | 32 |
| American suffragist | 19 |
| American stinger | 16 |
| American statesman Root | 23 |
| American statesman | 18 |
| American states org. | 20 |
| American state | 14 |
| American standard | 17 |
| American stage actor Alfred ____ | 32 |
| American spy org. | 17 |
| American sports org. | 20 |
| American sports car, for short | 30 |
| American sports car | 19 |
| American soul singer Redding | 28 |
| American sorcerers | 18 |
| American soprano who hosted a TV show in Italy | 46 |
| American songbird | 17 |
| American song hit of yore with The | 38 |
| American soldiers, to a limey | 29 |
| American soldiers of WWI | 24 |
| American soldier in WWI | 23 |
| American Society of Magazine Editors annual awards | 50 |
| American Socialist: 1855-1926 | 29 |
| American Socialist leader Eugene | 32 |
| American Socialist | 18 |
| American social reformer Baker | 30 |
| American snake | 14 |
| American skiing medalist at Lillehammer | 39 |
| American skier: 1945–76 | 30 |
| American Sisters of Charity founder | 35 |
| American Sign Language uses one | 31 |
| American showmen | 16 |
| American showman Barnum | 23 |
| American short story writer | 27 |
| American ship initials | 22 |
| American Shakers founder | 24 |
| American Shaker leader | 22 |
| American serfs | 14 |
| American seismologist | 21 |
| American sculptor George | 24 |
| American sculptor | 17 |
| American saint and family | 25 |
| American saint | 14 |
| American sable | 14 |