| Big bird that can't take wing | 33 |
| Big bird whose chicks are nurtured by the male | 46 |
| Big Bird's mammoth friend, familiarly | 41 |
| Big blasts from the past, briefly | 33 |
| Big Board's "big brother" | 39 |
| Big Board's Big Brother: Abbr. | 34 |
| Big boom maker in 1952, for short | 33 |
| Big brand of writing instruments | 32 |
| Big break for the Catholic church? | 34 |
| Big Brother's "1984" superstate | 45 |
| Big Brother's eyeballs, perhaps? | 36 |
| Big budget item for "Avatar," briefly | 47 |
| Big bulldozer company, for short | 32 |
| Big cat appendages for the ages? | 32 |
| Big celebration for a high schooler | 35 |
| Big cheese associated with Big Macs? | 36 |
| Big cheese following the East Run (6) | 37 |
| Big cheese linked with Big Macs? | 32 |
| Big cheese, in more ways than one | 33 |
| Big chunk of a drug company's budget | 40 |
| Big chunk of Christmas sales nowadays | 37 |
| Big chunks of concrete or marble | 32 |
| Big city mayor-turned-U.S. senator | 34 |
| Big city nearest the Golden Spike | 33 |
| Big cluster of tildes and cedillas? | 35 |
| Big company located in Times Square | 35 |
| Big conflict of the 1910s, briefly | 34 |
| Big corp. in the aerospace industry | 35 |
| Big corporation in copper alloys | 32 |
| Big Daddy player on 1950s Broadway | 34 |
| Big Declaration of Independence signature | 41 |
| Big dog: ___ Music Entertainment | 32 |
| Big dot-com headquartered in San Jose | 37 |
| Big drinker's "secret" | 36 |
| Big drinking night, stop #1 (happy hour) | 40 |
| Big drinking night, stop #2 (southwestern bar) | 46 |
| Big drinking night, stop #3 (tapas bar) | 39 |
| Big drinking night, stop #4 (college bar) | 41 |
| Big drinking night, stop #5 (night club) | 40 |
| Big drinking night, stop #6 (home at last) | 42 |
| Big East Conference team, for short | 35 |
| Big electronics defense contractor | 34 |
| Big employer of inspectors: Abbr. | 33 |
| Big events in the corporate world | 33 |
| Big expense in today's filmmaking | 37 |
| Big exporter of coconut cream and coconut oil | 45 |
| Big fan of "Gilligan's Island"? | 45 |
| Big fan of Captain Kirk and his crew | 36 |
| Big fans of a public prosecutor? | 32 |
| Big financial management co. on the NYSE | 40 |
| Big financial setback, figuratively | 35 |
| Big find at an archaeological dig | 33 |
| Big games for the Yanks or Sox, perhaps | 39 |
| Big Head Todd "Ann ___ Grandfather" | 45 |
| Big Head Todd : "___ Song" | 36 |
| Big hit for Bobby Day, back in the day | 38 |
| Big house that's not as big? | 32 |
| Big Indonesian tourist destination | 34 |
| Big initials among camping enthusiasts | 38 |
| Big initials in comedy syndication | 34 |
| Big initials in conspiracy theories | 35 |
| Big initials in industrial music | 32 |
| Big initials in nutritional supplements | 39 |
| Big initials on Mother's Day | 32 |
| Big inits. in cellular technology | 33 |
| Big inits. in defense contracting | 33 |
| Big inits. in Japanese computers | 32 |
| Big inits. in overseas broadcasting | 35 |
| Big inits. in paperback publishing | 34 |
| Big inits. in the defense industry | 34 |
| Big inits. in the record business | 33 |
| Big instrument in a marching band | 33 |
| Big Japanese computer maker: Abbr. | 34 |
| Big job for the makeup department | 33 |
| Big Joe Williams "Crawling King ___" | 46 |
| Big kahuna (with "head") | 34 |
| Big label Sony bought in '08 | 32 |
| Big letters in bowling equipment | 32 |
| Big letters in public broadcasting | 34 |
| Big Mac alternative, every so often | 35 |
| Big maker of communications satellites | 38 |
| Big maker of smoothies and energy bars | 38 |
| Big mfr. of point-of-sale terminals | 35 |
| Big moment for young Helen O'Connell | 40 |
| Big Mouth Billy Bass and things like that | 41 |
| Big multilanguage broadcaster, briefly | 38 |
| Big musical producer in the 1940s | 33 |
| Big mystery during the summer of 1980 | 37 |
| Big name among morning talk show hosts | 38 |
| Big name at the Peppermint Lounge | 33 |
| Big name in '40s-'50s Argentina | 39 |
| Big name in '60s counterculture | 35 |
| Big name in '60s peace activism | 35 |
| Big name in 1970s men's tennis | 34 |
| Big name in Abstraction-Création | 35 |
| Big name in action films catches game? | 38 |
| Big name in agricultural equipment | 34 |
| Big name in all-natural organic food for kids | 45 |
| Big name in alternative literary magazines | 42 |
| Big name in alternative magazines | 33 |