| Spanish city that's the capital of Asturias | 47 |
| Spanish city that gave sherry its name | 38 |
| Spanish city known for its aqueduct | 35 |
| Spanish city from which sherry takes it name | 44 |
| Spanish city for which sherry is named | 38 |
| Spanish city at the foot of Sierra Nevada | 41 |
| Spanish city and province on the Mediterranean | 46 |
| Spanish cession in the Spanish-American War | 43 |
| Spanish center for the L.A. Lakers Gasol | 40 |
| Spanish blue, look at, young fox | 32 |
| Spanish author: 1879–1930 | 32 |
| Spanish 101 alternative to "estás" | 47 |
| Spanish "no son," translated | 38 |
| Spanish ''ayes'' | 32 |
| Spaniard's foe in the Greater Antilles | 42 |
| Spaniard's "these" | 32 |
| Spaniard's "I love" | 33 |
| Spaniard who wrote "Dark Wedding": 1943 | 49 |
| Spandau prison's last inmate | 32 |
| Spain's Victoria Eugenia, familiarly | 40 |
| Spain's traditional currency | 32 |
| Spain's second-longest river | 32 |
| Spain's San Isidro and others | 33 |
| Spain's Queen Victoria Eugenia, familiarly | 46 |
| Spain's most voluminous river | 33 |
| Spain's Juan Carlos, for one | 32 |
| Spain's claim to fame put to shame in 1588 | 46 |
| Spain's capital city, as a sum? | 35 |
| Spain's 1973 Eurovision Song Contest entry | 46 |
| Spain and Portugal's peninsula | 34 |
| Spain "___ and Prayed" | 32 |
| Spahn's former companion in Boston | 38 |
| Spaghetti western film director Leone | 37 |
| Spaghetti western director Sergio | 33 |
| Spaghetti western director Leone | 32 |
| Spaghetti western composer Morricone | 36 |
| Spaghetti topping desired by all? | 33 |
| Spaghetti that smells and tastes terrible? | 42 |
| Spaghetti sauce seasoning, sometimes | 36 |
| Spaghetti makers' implements | 32 |
| Spades in a four-spades bridge contract, say | 44 |
| Spades bid worth 100 points if successful | 41 |
| Spade of "The Maltese Falcon" | 39 |
| Spacey/Bening Oscar-winning picture | 35 |
| Spacey's "Superman Returns" role | 46 |
| Spacey of "American Beauty" | 37 |
| Spacewalks and moonwalks, briefly | 33 |
| Spaceship that used the Moscow time zone | 40 |
| Spaces just under a bird's eyes | 35 |
| Spaces between objects or points | 32 |
| Spaces between lines, in printing | 33 |
| Spacely Space Sprockets employee | 32 |
| Spacek's "___ Man" | 32 |
| Spacek of "Crimes of the Heart" | 41 |
| Spacek of "Coal Miner's Daughter" | 47 |
| Spacek of ''Crimes of the Heart'' | 49 |
| Spacehog's debut "Resident ___" | 45 |
| Spacehog debut "Resident ___" | 39 |
| Spacehog "At Least I Got ___" | 39 |
| Spacecraft that began orbiting Saturn in 2004 | 45 |
| Spacecraft on a planet's surface | 36 |
| Space-signal searcher's acronym | 35 |
| Space-saving abbr. hidden in four puzzle answers | 48 |
| Space that ought to be in ZZ Topoly? | 36 |
| Space station whose final module was Priroda | 44 |
| Space station that operated on Moscow time | 42 |
| Space station that had a supply of vodka | 40 |
| Space station that fell to Earth in 2001 | 40 |
| Space station that crashed to Earth in 2001 | 43 |
| Space station launched by the Soviets | 37 |
| Space station for about 15 years | 32 |
| Space station assignment, for short | 35 |
| Space object with an event horizon | 34 |
| Space needed to store a character of text | 41 |
| Space Mountain and Splash Mountain | 34 |
| Space laser program of the '80s | 35 |
| Space found in Who-Turned-Out-the-Lights-opoly? | 47 |
| Space flight's starting point | 33 |
| Space film (with "The") | 33 |
| Space cartoon set in the year 3000 | 34 |
| Space between the eye and the bill of a bird | 44 |
| Space between the eye and the bill | 34 |
| Space between dotted lines, maybe | 33 |
| Space between a leaf's veins | 32 |
| Space between a leaf and its supporting stem | 44 |
| Space between a bird's eye and bill | 39 |
| Space bar neighbor, on some keyboards | 37 |
| Spa visitor who doesn't pay the bill? | 41 |
| Spa offering that's not quite godlike? | 42 |
| Spa in France's Haute-Savoie department | 43 |
| Spa employee, generally speaking | 32 |
| Sp. currency replaced by the euro | 33 |
| Sp-[gasp]-speaks like th-[sniffle]-this | 39 |
| Soyer's "Girl in a White ___" | 43 |
| Soybean appetizer served at sushi bars | 38 |
| Soy, north of the Mexican border | 32 |
| Soviet W.W. II foreign affairs commissar | 40 |
| Soviet spymaster in a John le Carré trilogy | 46 |
| Soviet spy Rudolf and actor Walter | 34 |
| Soviet president: 1923–46 | 32 |