| Species that serves as an early warning system | 46 |
| Species of Tolkien's Arwen Evenstar | 39 |
| Species of falcon also called an American kestrel | 49 |
| Specialty that involves the brain and spinal cord | 49 |
| Specialty sandwich from Domino's? | 37 |
| Specialty retailers' domains | 32 |
| Specialty of the funny Avon lady? | 33 |
| Specialty of Russian painter Aivazovsky | 39 |
| Specialty of Robert McG. Thomas Jr. | 35 |
| Specialty of Edward Scissorhands | 32 |
| Specialty of certain "deliverymen" | 44 |
| Specialty of an M.D. who deals with head cases? | 47 |
| Specialty of a Library of Congress | 34 |
| Specialty of a couples therapist? | 33 |
| Specialty in history as well as medicine? | 41 |
| Specialty for some thoroughbreds | 32 |
| Specialty for Jose Reyes of the Mets | 36 |
| Specialties of tonsorial artists | 32 |
| Specialties at Wilhelm's fruit stand? | 41 |
| Specially formed, as a committee | 32 |
| Specially edited version of a film | 34 |
| Specially created, as a committee | 33 |
| Specialized procedures, so to speak | 35 |
| Specialized "We made it!" | 35 |
| Specialists' underlings: Abbr. | 34 |
| Specialist's superior: Abbr. | 32 |
| Specialist's offering, in court | 35 |
| Specialist whose field covers 675,000 species | 45 |
| Specialist who treats Santa's broken ankle? | 47 |
| Specialist who might treat otitis interna | 41 |
| Specialist who might conduct a balance test | 43 |
| Specialist who listens to sole music? | 37 |
| Specialist who keeps a Kardashian healthy? | 42 |
| Specialist who delivers for the Sopranos? | 41 |
| Specialist in the study of nutrition | 36 |
| Specialist for cooks who are kooks? | 35 |
| Special-request flight meal option | 34 |
| Special-handling designation at the post office | 47 |
| Special-care job at the cleaner's | 37 |
| Special ___ (super-secret military unit) | 40 |
| Special seating area in an airplane | 35 |
| Special portion of a vintner's output | 41 |
| Special Olympics founder Shriver | 32 |
| Special officer's commission | 32 |
| Special offer at an airline Web site | 36 |
| Special offer at a car dealership | 33 |
| Special intuition, in modern lingo | 34 |
| Special gift for apartment hunters? | 35 |
| Special Forces order when greeting a lady? | 42 |
| Special effects used in "Avatar," e.g. | 48 |
| Special effects technique, briefly | 34 |
| Special effects graphics, briefly | 33 |
| Special delivery from a dating service? | 39 |
| Special communicative skill, briefly | 36 |
| Special attention for a patient, in brief | 41 |
| Special at most restaurants and diners | 38 |
| Special area at an outdoor concert | 34 |
| Special Agent ___ (Disney channel panda) | 40 |
| Special Agent on Playhouse Disney | 33 |
| Special "Jeopardy!" square | 36 |
| Spec on an architect's blueprint? | 37 |
| Spears' 2000 partner in McDonald's ads | 46 |
| Spears and such from 200 BCE China? | 35 |
| Spear-carrier's genre, sometimes | 36 |
| Speaks with brutal honesty ... or not | 37 |
| Speaks after several drinks, perhaps | 36 |
| Speaks after a few drinks, perhaps | 34 |
| Speaking with one's hands: Abbr. | 36 |
| Speaking with one's hands (abbr.) | 37 |
| Speaking of repeatedly, to a Brit | 33 |
| Speaker's place at RnR Hall of Fame induction | 49 |
| Speaker's amplifying aid, briefly | 37 |
| Speaker with the nickname "Spoke" | 43 |
| Speaker with an unusually loud voice | 36 |
| Speaker with a .345 career batting average | 42 |
| Speaker of the quote, familiarly | 32 |
| Speaker of the quote born 7/30/1890 | 35 |
| Speaker of the House: 1801–07 | 36 |
| Speaker of the house's spot? | 32 |
| Speaker of the House who battled Bill | 37 |
| Speaker of the House from 1977 to 1987 | 38 |
| Speaker of the House before Dennis | 34 |
| Speaker of the House after Gingrich | 35 |
| Speaker of the Baseball Hall of Fame | 36 |
| Speaker just before "Over the Rainbow" | 48 |
| Speaker in the Baseball Hall-of-Fame | 36 |
| Speaker in the Baseball Hall of Fame | 36 |
| Speaker between other speakers, perhaps | 39 |
| Speaker between Hastert and Boehner | 35 |
| Speaker at Kennedy's inauguration | 37 |
| Speakeasy's distilling locale | 33 |
| Speak without restraint (with "it") | 45 |
| Speak sharply, with "at" | 34 |
| Speak poorly of, or speak poorly | 32 |
| Speak on impulse, with "out" | 38 |
| Speak into the drive-thru mike, say | 35 |
| Speak in a rhythmic and flowery way | 35 |
| Speak freely, with "up" | 33 |
| Speak for the Congressional Record, say | 39 |
| Speak after downing a bottle of rum | 35 |