| A sign of things to come | 24 |
| A sign of elation or optimism | 29 |
| A side of the Big Apple | 23 |
| A sibling of Cottontail | 23 |
| A shuttlecock sails over it | 27 |
| A shot might indicate it | 24 |
| A shot in the arm, say | 22 |
| A shot in the arm, maybe | 24 |
| A short, thickset haddock? | 26 |
| A short story, in Sept-Isles | 29 |
| A shootout might end it | 23 |
| A shooter takes it off | 22 |
| A shooter might take it | 23 |
| A shogun may tie one on | 23 |
| A shoe presses against it | 25 |
| A shirt tag may tickle it | 25 |
| A ship, to crew members | 23 |
| A ship may appear on it | 23 |
| A shift lever changes them | 26 |
| A sheriff may round one up | 26 |
| A sheriff may be seen in it | 27 |
| A shepherd, originally | 22 |
| A shepherd shepherds it | 23 |
| A shelf in a kitchen cabinet? | 29 |
| A Shaw who married a Gardner | 28 |
| A sharp, by another name | 24 |
| A shark might give you one | 26 |
| A Shakespeare contemporary | 26 |
| A seventh-century date | 22 |
| A seven-footer, quite often | 27 |
| A Seven Sisters school | 22 |
| A serving of grog or rum | 24 |
| A serious one may be red | 24 |
| A Serious Man filmmakers | 24 |
| A sergeant may order one | 24 |
| A semihard yellow cheese | 24 |
| A semi lacks a front one | 24 |
| A seemingly endless series | 26 |
| A secretary might take it | 25 |
| A secret may be told in one | 27 |
| A second shift, possibly | 24 |
| A seasoning, in Savoie | 22 |
| A search may be done with it | 28 |
| A seamstress should be __ | 25 |
| A sea was named for him | 23 |
| A scuttle might scoop from it | 29 |
| A screech may accompany it | 26 |
| A scout may do a good one | 25 |
| A Scottish loch, for example | 28 |
| A Scot and his relatives | 24 |
| A sci-fi writer's award | 27 |
| A schussboomer uses them | 24 |
| A scandal often ruins one | 25 |
| A satellite of Jupiter | 22 |
| A satellite may be kept in it | 29 |
| A salmon that has spawned | 25 |
| A Saarinen and namesakes | 24 |
| A Russian chess master | 22 |
| A runner might enter it | 23 |
| A runner may enter one | 22 |
| A rung on the ladder of life | 28 |
| A ruler before the revolution | 29 |
| A RR's feline mascot | 24 |
| A round of golf, informally | 27 |
| A round number ends in it | 25 |
| A round may be added to it | 26 |
| A round at the tavern, say | 26 |
| A round at the tavern, often | 28 |
| A Rosenberg and others | 22 |
| A Rose, by another name | 23 |
| A Rose by another name | 22 |
| A rooster might top it | 22 |
| A room with una vista? | 22 |
| A room of one's own | 23 |
| A rolling stone gathers none | 28 |
| A roll of 4 and 6, in craps | 27 |
| A role some people play | 23 |
| A role for Beverly Sills | 24 |
| A Roe with a fishy pitch | 24 |
| A Rocky Mountain state | 22 |
| A Rockefeller, sometimes | 24 |
| A Rockefeller nickname | 22 |
| A robin's are blue | 22 |
| A roaring success since 1912 | 28 |
| A river runs through it | 23 |
| A river or a Teletubby | 22 |
| A river might run through it | 28 |
| A river and a cartoonist | 24 |
| A rival of Laver and Emerson | 28 |
| A rival of Carter in 1976 | 25 |
| A rival in a Sheridan play | 26 |
| A rip-off for readers? | 22 |
| A ringmaster will do it | 23 |
| A ring may indicate it | 22 |
| A ring doesn't have them | 28 |
| A ring bearer may go down it | 28 |
| A ridge, especially on cloth | 28 |
| A Rice Krispies fellow | 22 |
| A rhythm guitarist plays them | 29 |
| A result of nebulization | 24 |