| Chain hotel in Madrid? | 22 |
| Chain hotel, for short | 22 |
| Chain in a cell | 15 |
| Chain in bio class | 18 |
| Chain in biology | 16 |
| Chain in the upper St. Lawrence River | 37 |
| Chain including the Matterhorn | 30 |
| Chain item | 10 |
| Chain items | 11 |
| Chain known for breakfast | 25 |
| Chain known for breakfasts | 26 |
| Chain known for butter pecan syrup | 34 |
| Chain letter, perhaps | 21 |
| Chain letters | 13 |
| Chain letters, to geneticists | 29 |
| Chain letters, usually | 22 |
| Chain letters? | 14 |
| Chain link? | 11 |
| Chain links: Abbr. | 18 |
| Chain links?: Abbr. | 19 |
| Chain mail | 10 |
| Chain mail and such | 19 |
| Chain mail, e.g. | 16 |
| Chain makeup | 12 |
| Chain material | 14 |
| Chain named for a Stones hit | 28 |
| Chain named for its founders, the Raffel brothers | 49 |
| Chain named for two oceans | 26 |
| Chain of auto parts stores | 26 |
| Chain of big-box electronics stores | 35 |
| Chain of car care shops | 23 |
| Chain of connected ideas | 24 |
| Chain of evidence? | 18 |
| Chain of hills | 14 |
| Chain of life? | 14 |
| Chain of mountains | 18 |
| Chain of off-price department stores | 36 |
| Chain of sandy islands in Italy | 31 |
| Chain of treeless rolling hills | 31 |
| Chain offering Country Griddle Cakes | 36 |
| Chain offering funeral services by the dozen? | 45 |
| Chain offering Moons Over My Hammy | 34 |
| Chain on the Mid-Atlantic Ridge | 31 |
| Chain or street | 15 |
| Chain owned by Barnes & Noble | 33 |
| Chain part | 10 |
| Chain part: Abbr. | 17 |
| Chain partner | 13 |
| Chain parts | 11 |
| Chain parts: Abbr. | 18 |
| Chain piece | 11 |
| Chain pitched by Jared | 22 |
| Chain pitched by Michael Phelps | 31 |
| Chain pts.? | 11 |
| Chain reaction facilitator | 26 |
| Chain reaction metaphor | 23 |
| Chain reaction pioneer | 22 |
| Chain reaction requirement | 26 |
| Chain restaurant based in Louisville | 36 |
| Chain restaurant with a blue roof | 33 |
| Chain restaurants with soft-serve, for short | 44 |
| Chain retailer that merged with Sears | 37 |
| Chain section | 13 |
| Chain segment | 13 |
| Chain selling desserts | 22 |
| Chain selling stacks | 20 |
| Chain serving stacks | 20 |
| Chain serving Torpedoes and Bullets | 35 |
| Chain site | 10 |
| Chain smoker on "The Simpsons" | 40 |
| Chain sounds | 12 |
| Chain store employee | 20 |
| Chain store founded by Ingvar Kamprad | 37 |
| Chain store name | 16 |
| Chain store selling gates and crates | 36 |
| Chain store that began as The Golden Rule in 1902 | 49 |
| Chain store that originally published Woman's Day | 53 |
| Chain store that sells baseball caps | 36 |
| Chain stores? | 13 |
| Chain that began in Toluca Lake, Calif. | 39 |
| Chain that calls itself "America's Drive-In" | 58 |
| Chain that dropped its full name in 1991 | 40 |
| Chain that filed for Chapter 11 in December 2010 | 48 |
| Chain that makes a lot of dough | 31 |
| Chain that merged with AMC Theatres | 35 |
| Chain that sells Borgsjö bookcases | 37 |
| Chain that sells links | 22 |
| Chain that sells waffles like hot cakes? | 40 |
| Chain that serves over 1.5 million gallons of syrup per year | 60 |
| Chain that serves the Burrito Bol | 33 |
| Chain that serves the Grand Slam breakfast | 42 |
| Chain that specializes in personal information? | 47 |
| Chain unit | 10 |
| Chain units | 11 |
| Chain units: Abbr. | 18 |
| Chain where people might geocache | 33 |
| Chain whose name derives from its original room rate | 52 |
| Chain with a cat/dog logo | 25 |
| Chain with a cowboy hat logo | 28 |
| Chain with a red cowboy hat logo | 32 |