| Sequel to "Thriller" | 30 |
| Sequel to "Twilight" | 30 |
| Sequel to "Typee" | 27 |
| Sequel to "Willard" | 29 |
| Sequel to a 2013 3D film in which Manny Pacquiao spars in space? (Happy New Year to adolescent Jesus!) | 102 |
| Sequel to a Costner film? | 25 |
| Sequel to a store fire | 22 |
| Sequel to Buck's "The Good Earth" | 47 |
| Sequel to Christopher Paolini's "Eragon" which Entertainment Weekly named "Worst Book of 2005" | 118 |
| Sequel to conviction | 20 |
| Sequel to Kerouac's "On the Road" | 47 |
| Sequel to Melville's "Typee" | 42 |
| Sequel to Puzo's "The Last Don" | 45 |
| Sequel to the Sammy Davis Jr. film "Salt and Pepper" | 62 |
| Sequel with Streisand | 21 |
| Sequel word | 11 |
| Sequel words | 12 |
| Sequel writer's other job? | 30 |
| Sequel writer's work? | 25 |
| Sequel's sequel | 19 |
| Sequel's tag, at times | 26 |
| Sequel, often | 13 |
| Sequel-title word | 17 |
| Sequel-to-a-sequel designation | 30 |
| Sequence | 8 |
| Sequence after JKL | 18 |
| Sequence associated with 6 | 26 |
| Sequence before Friday's | 28 |
| Sequence before W | 17 |
| Sequence found in this puzzle's five longest answers | 56 |
| Sequence in heredity | 20 |
| Sequence late in the alphabet | 29 |
| Sequence of bits | 16 |
| Sequence of DNA | 15 |
| Sequence of ecological stages | 29 |
| Sequence of events | 18 |
| Sequence of gigs | 16 |
| Sequence of notes | 17 |
| Sequence of scenes | 18 |
| Sequence of stages, in ecology | 30 |
| Sequence of unspecified size, in math | 37 |
| Sequence of victories | 21 |
| Sequence often seen above WXYZ | 30 |
| Sequence opener | 15 |
| Sequence position | 17 |
| Sequence seen between two esses | 31 |
| Sequence sung by kids | 21 |
| Sequence with a Y, sometimes | 28 |
| Sequence with two hyphens: Abbr. | 32 |
| Sequence with Y, sometimes | 26 |
| Sequence, in Paris | 18 |
| Sequence: Fr. | 13 |
| Sequenced | 9 |
| Sequencer-driven music | 22 |
| Sequences | 9 |
| Sequences of sovereigns | 23 |
| Sequences with two dashes: Abbr. | 32 |
| Sequencing target, briefly | 26 |
| Sequent | 7 |
| Sequential | 10 |
| Sequential bet | 14 |
| Sequential card game | 20 |
| Sequential events | 17 |
| Sequential letters | 18 |
| Sequential list of events | 25 |
| Sequential notes | 16 |
| Sequential scale notes | 22 |
| Sequentially | 12 |
| Sequentially following | 22 |
| Sequester | 9 |
| Sequestered | 11 |
| Sequestered room | 16 |
| Sequestered rooms | 17 |
| Sequestering, legally speaking | 30 |
| Sequesters | 10 |
| Sequestration | 13 |
| Sequin | 6 |
| Sequin alternative | 18 |
| Sequined | 8 |
| Sequins | 7 |
| Sequins e.g. | 13 |
| Sequoia | 7 |
| Sequoia feature | 15 |
| Sequoia fluid | 13 |
| Sequoia in Calif. (world's largest living thing) | 52 |
| Sequoia or sycamore | 19 |
| Sequoia or tulip | 16 |
| Sequoia, e.g. | 13 |
| Sequoia, for one | 16 |
| Sequoias | 8 |
| Sequoias and Siennas | 20 |
| Sequoias, e.g. | 14 |
| Sequoyah's tribe | 20 |
| Sequoyah, for one | 17 |
| Ser, across the Pyrenees | 24 |
| Ser. deliverer | 14 |
| Seraglio | 8 |
| Seraglio area | 13 |
| Seraglio chamber | 16 |
| Seraglio chambers | 17 |