| First president buried at Arlington National Cemetery | 53 |
| First president not born in the continental U.S. | 48 |
| First president of Angola | 25 |
| First president of Czechoslovakia | 33 |
| First president of Gabon | 24 |
| First president of Germany | 26 |
| First president of Indonesia | 28 |
| First president of Korea | 24 |
| First president of League of Women Voters | 41 |
| First president of Mali | 23 |
| First president of S. Korea | 27 |
| First president of South Korea | 30 |
| First president of Tanzania | 27 |
| First president of the 20th century | 35 |
| First president of the AFL-CIO | 30 |
| First president of the Czech Republic | 37 |
| First president of the German republic, 1919 | 44 |
| First president of the SCLC | 27 |
| First president of the Sierra Club | 34 |
| First president of the Transvaal | 32 |
| First President Roosevelt | 25 |
| First president to file an income tax return | 44 |
| First president to get married while in office | 46 |
| First president to have a telephone in the White House | 54 |
| First president to have a veto overridden | 41 |
| First president to live in the White House | 42 |
| First president to marry while in office | 40 |
| First president to occupy the Oval Office | 41 |
| First president to occupy the White House | 41 |
| First president to take office by succession | 44 |
| First president to take up golf | 31 |
| First president to throw a ceremonial opening day pitch | 55 |
| First president to throw an Opening Day pitch | 45 |
| First president to visit the West Coast while in office | 55 |
| First president who was the son of a president | 46 |
| First president who wasn't elected | 38 |
| First president whose name ends in a vowel other than E or Y | 60 |
| First president with a Twitter account | 38 |
| First presidential couple | 25 |
| First prime | 11 |
| First prime minister of Burma | 29 |
| First prime minister of free India | 34 |
| First prime minister of Ghana | 29 |
| First prime minister of Great Britain | 37 |
| First prime minister of India | 29 |
| First prime minister of India or jacket style | 45 |
| First prime minister of the U.S.S.R. | 36 |
| First prime número | 21 |
| First prime number | 18 |
| First principle | 15 |
| First principle of Kwanzaa | 26 |
| First principles | 16 |
| First printing, say | 19 |
| First prints of movies | 22 |
| First priority of an Australian beverage company? | 49 |
| First private engineering school in the U.S. | 44 |
| First privately owned satellite | 31 |
| First prize at a fair | 21 |
| First prize at the 1992 Olympics | 32 |
| First pro team to play on artificial turf | 41 |
| First product sold by L.L. Bean | 31 |
| First professional musician to become Chairman of the Board of Lincoln Center | 77 |
| First pronoun in "America" | 36 |
| First pronoun in "Little Miss Muffet" | 47 |
| First Prophet of Islam | 22 |
| First public appearance | 23 |
| First published black woman poet in America | 43 |
| First publisher of Hunter S. Thompson's "Fear and Loathing in Las Vegas" | 86 |
| First publisher of the game Mouse Trap | 38 |
| First Puccini Turandot: 1926 | 28 |
| First Pulitzer Prize novelist | 29 |
| First Pulitzer Prize novelist: 1918 | 35 |
| First punch of an old Roman bout? | 33 |
| First quarter appearance | 24 |
| First queen of Carthage | 23 |
| First queen of Great Britain | 28 |
| First question at a start-up company? | 37 |
| First rabies vaccine creator | 28 |
| First radio code word? | 22 |
| First radio station | 19 |
| First rank | 10 |
| First rap group to appear on the cover of Rolling Stone | 55 |
| First rapper to win a Best Song Oscar | 37 |
| First rapper to win an Oscar for Best Original Song | 51 |
| First rapper to win the Best Original Song Academy Award | 56 |
| First rate | 10 |
| First razor with a pivoting head | 32 |
| First reader canine | 19 |
| First Reality Primetime Emmy winner | 35 |
| First recipient of the Harvard AIDS Initiative Leadership Award | 63 |
| First recorded Chinese dynasty | 30 |
| First recording | 15 |
| First Red Army leader | 21 |
| First refugee named Canadian Prime Minister | 43 |
| First Reich for short | 22 |
| First Reich rulers: 936-1002 | 28 |
| First rendering, say | 20 |
| First rental car company to be located at an airport | 52 |
| First Republic of Texas president | 33 |
| First Republican President | 26 |