| Seminal punk rock label operated by Black Flag | 46 |
| Seminal short-story collection by Asimov | 40 |
| Seminole rival, in college sports | 33 |
| Seminole War major with counties named after him | 48 |
| Seminole War officer for whom a county was named | 48 |
| Semis happen near the end of them | 33 |
| Semisoft cheese with an orange rind | 35 |
| Semisonic "Great Divide" song (Abbr.) | 47 |
| Semisonic song off "Great Divide" | 43 |
| Semitic language written with the Roman alphabet | 48 |
| Semiweekly Martha's Vineyard newspaper | 42 |
| Sen. Bayh's senior counterpart | 34 |
| Sen. Biden represented it: Abbr. | 32 |
| Sen. Gaylord ___, who originated Earth Day | 42 |
| Sen. Gillibrand represents it: Abbr. | 36 |
| Sen. Lieberman's affiliation, now | 37 |
| Sen. Lieberman's classification | 35 |
| Sen. McGovern's birthplace in S.D. | 38 |
| Sen. Schumer represents it: Abbr. | 33 |
| Sen. Sessions's state: Abbr. | 32 |
| Sen. Weicker's colleague from Conn. | 39 |
| Senate Agriculture Committee head | 33 |
| Senate and people of Rome: Abbr. | 32 |
| Senate Foreign Relations Committee chair, 2003-07 | 49 |
| Senate GOP leader between Dole and Frist | 40 |
| Senate Judiciary Committee chairman | 35 |
| Senate Majority Leader after Frist | 34 |
| Senate majority leader before Reid | 34 |
| Senate majority leader before Trent Lott | 40 |
| Senate majority leader since 2007 | 33 |
| Senate Majority Whip before Reid | 32 |
| Senate minority leader McConnell | 32 |
| Senate Republican leader before Frist | 37 |
| Senate situation requiring the Vice President | 45 |
| Senate Watergate committee chair Sam | 36 |
| Senate word that only sounds exciting | 37 |
| Senate's David and comedy's Richard | 43 |
| Senate's Democratic Chief Deputy Whip | 41 |
| Senator aboard "Discovery" | 36 |
| Senator Alexander from Tennessee | 32 |
| Senator Christopher from Connecticut | 36 |
| Senator Feinstein of California | 32 |
| Senator for 47 straight years, a Senate record | 46 |
| Senator for whom an IRA is named | 32 |
| Senator formerly on "SNL" | 35 |
| Senator from California from 1969 to 1993 | 41 |
| Senator from Kansas or North Carolina | 37 |
| Senator Jake who flew on space shuttle Discovery | 48 |
| Senator Jon of non-factual statements | 37 |
| Senator or congressman, for short | 33 |
| Senator Phil who co-authored a budget act | 41 |
| Senator Sam of the Watergate hearings | 37 |
| Senator Sam who investigated Watergate | 38 |
| Senator Sanders of Vt., on ballots | 34 |
| Senator Schumer's predecessor | 33 |
| Senator Scott from South Carolina | 33 |
| Senator that gave his name to a federal aid grant | 49 |
| Senator Thurmond who left office at age 100 | 43 |
| Senator who gave Golden Fleece awards | 37 |
| Senator who isn't a strict schoolteacher | 44 |
| Senator who served on the USS Gridley | 37 |
| Senator who succeeded John Stennis | 34 |
| Senator's adjective for a colleague | 39 |
| Senator/campaigner Joe from Delaware | 36 |
| Senators and representatives, for short | 39 |
| Senators Bunning, DeMint, Risch, and Webb | 41 |
| Senators hear it before facing off | 34 |
| Senators' advantage in Ottawa | 33 |
| Senatus Populusque Romanus: Abbr. | 33 |
| Send a center to Sacramento, say | 32 |
| Send a document over phone lines | 32 |
| Send a kid from Santiago to Alaska? | 35 |
| Send a message in Morse code, e.g. | 34 |
| Send a tax return via cyberspace | 32 |
| Send a telegraph to designer Pierre? | 36 |
| Send elsewhere, as to a specialist | 34 |
| Send explicit come-ons by cell phone | 36 |
| Send flowers and love letters, say | 34 |
| Send for a different size, perhaps | 34 |
| Send for a special bridal accessory? | 36 |
| Send in one's tax forms without using a stamp | 49 |
| Send more supplies to the troops | 32 |
| Send out a save the date card, e.g. | 35 |
| Send out, in the realm of physical media | 40 |
| Send playwright Terrence back into custody? | 43 |
| Send Rover over for the weekend? | 32 |
| Send something down the wrong pipe, as it were | 46 |
| Send tax returns via the Internet | 33 |
| Send to one's room without supper, say | 42 |
| Send, "Star Trek"-style | 33 |
| Send, as a note to a kindergarten teacher | 41 |
| Sendak’s “Where the Wild Things ___” | 48 |
| Sender of an anonymous valentine, perhaps | 41 |
| Sender of care packages to soldiers | 35 |
| Sender of many monthly checks (abbr.) | 37 |
| Sender of news messages, once (3-7) | 35 |
| Sending a ___ the moon (1960's goal) | 40 |
| Sending flowers to a courtroom worker? | 38 |
| Sending Gossage to an early shower? | 35 |
| Sending out a radar-jamming signal? | 35 |