| September happenings, often | 27 |
| September outing, usually | 25 |
| September seasonal shift | 24 |
| September setting in St. Pete | 29 |
| September sprint of sorts | 25 |
| September's number | 22 |
| September's thirty | 22 |
| Septembre's preceder | 24 |
| Septennial affliction? | 22 |
| Septic or social starter | 24 |
| Septic tank bacterium, e.g. | 27 |
| Septic tank organism, e.g. | 26 |
| Septiembre, por ejemplo | 23 |
| Septuagenarian's goal | 25 |
| Sequel set on the moon LV-426 | 29 |
| Sequel to "Typee" | 27 |
| Sequel to "Willard" | 29 |
| Sequel to a Costner film? | 25 |
| Sequel to a store fire | 22 |
| Sequel writer's work? | 25 |
| Sequel's tag, at times | 26 |
| Sequence associated with 6 | 26 |
| Sequence before Friday's | 28 |
| Sequence late in the alphabet | 29 |
| Sequence of ecological stages | 29 |
| Sequence with a Y, sometimes | 28 |
| Sequence with Y, sometimes | 26 |
| Sequencer-driven music | 22 |
| Sequences of sovereigns | 23 |
| Sequencing target, briefly | 26 |
| Sequential list of events | 25 |
| Sequential scale notes | 22 |
| Sequentially following | 22 |
| Ser, across the Pyrenees | 24 |
| Seraph's song: Var. | 23 |
| Seraphim and cherubim, e.g. | 27 |
| Seraphim, to Sevillians | 23 |
| Serb or Croat, among others | 27 |
| Serb or Croat, for example | 26 |
| Serbian river to the Danube | 27 |
| Serbian tennis pro Ivanovic | 27 |
| Serbian's neighbor | 22 |
| Serbian-American inventor | 25 |
| Serbian-born physicist Nikola | 29 |
| Serbian-born sports great | 25 |
| Serbs and Croats, e.g. | 22 |
| Serena Williams triumph | 23 |
| Serena Williams, often | 22 |
| Serena's serve, sometimes | 29 |
| Serena's specialty | 22 |
| Serenade accompaniment | 22 |
| Serenade to singer Moore? | 25 |
| Serenade with a guitar | 22 |
| Serenade, as the heavens | 24 |
| Serenaded a famous tenor? | 25 |
| Serenader's selection | 25 |
| Serenader's sentiment | 25 |
| Serenader's subject | 23 |
| Serenades, as the moon | 22 |
| Serendipitous occurrence | 24 |
| Serendipitous occurrences | 25 |
| Serendipitous, perhaps | 22 |
| Serengeti National Park trek | 28 |
| Serengeti National Park? | 24 |
| Serf in Ethelred's day | 26 |
| Serf of ancient Sparta | 22 |
| Serf, originally a Laconian | 27 |
| Serfs in Ethelred's day | 27 |
| Serge Gainsbourg's style | 28 |
| Sergeant Bilko portrayer | 24 |
| Sergeant Friday portrayer | 25 |
| Sergeant Friday's request | 29 |
| Sergeant in "MASH" | 28 |
| Sergeant in a 1941 film | 23 |
| Sergeant of '50s TV | 23 |
| Sergeant of W.W. I fame | 23 |
| Sergeant or corporal, e,g, | 26 |
| Sergeant or corporal, e.g. | 26 |
| Sergeant Pepper's group | 27 |
| Sergeant Preston's horse | 28 |
| Sergeant Schultz's boss | 27 |
| Sergeant Snorkel's dog | 26 |
| Sergeant with badge 714 | 23 |
| Sergeant York's st. | 23 |
| Sergeant ___, W.W. I hero | 25 |
| Sergeant's command | 22 |
| Sergeant's inferior | 23 |
| Sergeant's insignia | 23 |
| Sergeant's order, perhaps | 29 |
| Sergeant's right-hand man | 29 |
| Sergeant's station | 22 |
| Sergeants and corporals | 23 |
| Sergeants and corporals, e.g. | 29 |
| Sergeants major, e.g.: Abbr. | 28 |
| Sergeants' commands | 23 |
| Sergio of spaghetti Westerns | 28 |
| Sergio ___, movie director | 26 |
| Seria or comique preceder | 25 |
| Serial blackjack wielders? | 26 |
| Serial novel's start | 24 |