| First chips in the center | 25 |
| First chimp to orbit Earth | 26 |
| First child of 1977-81 | 22 |
| First Chief Justice John | 24 |
| First Chief Justice afoot? | 26 |
| First chapter in a primer | 25 |
| First chair in the air | 22 |
| First cervical vertebra | 23 |
| First century Roman emperor | 27 |
| First cardinal in Mexico | 24 |
| First card below the faces | 26 |
| First capital of Japan | 22 |
| First capital of California | 27 |
| First capital of Alaska | 23 |
| First Canuck satellite to fly | 29 |
| First Canadian at Cooperstown | 29 |
| First Canadian astronaut | 24 |
| First Burmese prime minister | 28 |
| First Brazilian airline | 23 |
| First book of the Bible | 23 |
| First bone transplant donor? | 28 |
| First Bond movie villain | 24 |
| First black billionaire | 23 |
| First billionaire book author | 29 |
| First bidder, at bridge | 23 |
| First bidder in bridge games | 28 |
| First Biblical grandson | 23 |
| First Biblical casualty | 23 |
| First Best Actress winner | 25 |
| First battle of Revolution | 26 |
| First baseman's glove | 25 |
| First baseman Palmiero | 22 |
| First baseman Palmeiro | 22 |
| First baseman of comedy | 23 |
| First baseman Martinez | 22 |
| First baseball Hall of Famer | 28 |
| First baseball commissioner | 27 |
| First baby picture, perhaps | 27 |
| First baby picture, often | 25 |
| First asteroid discovered | 25 |
| First assembly-line carmaker | 28 |
| First artificial satellite | 26 |
| First application blank | 23 |
| First apartment, perhaps | 24 |
| First anniversary gift | 22 |
| First animal, in a way | 22 |
| First and ___ (football term) | 29 |
| First and second, for two | 25 |
| First and second, e.g. | 22 |
| First and Second places? | 24 |
| First and second for example | 29 |
| First and reverse, e.g. | 23 |
| First and last quarters, e.g. | 29 |
| First and foremost: Abbr. | 25 |
| First among the children | 24 |
| First American woman in space | 29 |
| First American to orbit Earth | 29 |
| First American orbiter | 22 |
| First American in space | 23 |
| First American in orbit | 23 |
| First American auto company | 27 |
| First Amendment lobbying gp. | 28 |
| First Amendment guarantee | 25 |
| First Amendment freedom | 23 |
| First Amendment concern | 23 |
| First Amendment advocacy grp. | 29 |
| First Amendment advocacy gp. | 28 |
| First album track, perhaps | 26 |
| First Alaskan governor | 22 |
| First aide, for short? | 22 |
| First aid technique (abbr.) | 27 |
| First aid provider, for short | 29 |
| First aid provider, briefly | 27 |
| First aid for a sprain | 22 |
| First age in geologic history | 29 |
| First AFL president, Samuel | 27 |
| First actor to play Loman | 25 |
| First A.F.L.-C.I.O. president | 29 |
| First 45 maker, briefly | 23 |
| First 007 flick (abbr.) | 23 |
| First "O" of O-O-O | 28 |
| First "Great" pope | 28 |
| First "Bond girl" | 27 |
| First second or third | 22 |
| Firmly twisted wool yarn | 24 |
| Firmly loyal, as friends | 24 |
| Firmly affixed, in a way | 24 |
| Firma or cotta lead-in | 22 |
| Firm with a spokesduck | 22 |
| Firm wheels, for short | 22 |
| Firm up, as one's muscles | 29 |
| Firm or figure preceder | 23 |
| Firm in one's view | 22 |
| Firm figure, informally | 23 |
| Firm engaged in trading | 23 |
| Firm Dandy Warhols song? | 24 |
| Firm control, metaphorically | 28 |
| Firm container? (abbr.) | 23 |
| Firm cheese, for short? | 23 |
| Firm assistant, briefly | 23 |