| First set of wheels, maybe | 26 |
| First sergeant, informally | 26 |
| First senator in space | 22 |
| First semester offerings | 24 |
| First self-propelled spaceman | 29 |
| First section of a tome | 23 |
| First secretary of war | 22 |
| First Seahawk quarterback Jim | 29 |
| First schizophrenic problem? | 28 |
| First schizophrenicproblem? | 28 |
| First Russian to orbit Earth | 28 |
| First Russian Orthodox saint | 28 |
| First rung on a ladder | 22 |
| First run of the still | 22 |
| First ruler of the Slavs | 24 |
| First ruler of all Egypt | 24 |
| First rule of lion taming? | 26 |
| First round pick of the Magic | 29 |
| First Roman to be deified | 25 |
| First rock from the sun | 23 |
| First response to a call | 24 |
| First responders: Abbr. | 23 |
| First responders, for short | 27 |
| First responders, briefly | 25 |
| First responders, at times | 26 |
| First responders (abbr.) | 24 |
| First responder, say: Abbr. | 27 |
| First responder, perhaps | 24 |
| First responder, often | 22 |
| First responder, maybe | 22 |
| First responder, for short | 26 |
| First responder, briefly | 24 |
| First responder's skill | 27 |
| First residence (option 2) | 26 |
| First residence (option 1) | 26 |
| First residence (last option) | 29 |
| First Republican President | 26 |
| First Reich rulers: 936-1002 | 28 |
| First Reich for short | 22 |
| First radio code word? | 22 |
| First rabies vaccine creator | 28 |
| First queen of Great Britain | 28 |
| First queen of Carthage | 23 |
| First quarter appearance | 24 |
| First Pulitzer Prize novelist | 29 |
| First Puccini Turandot: 1926 | 28 |
| First public appearance | 23 |
| First Prophet of Islam | 22 |
| First prints of movies | 22 |
| First principle of Kwanzaa | 26 |
| First prime minister of India | 29 |
| First prime minister of Ghana | 29 |
| First prime minister of Burma | 29 |
| First presidential couple | 25 |
| First President Roosevelt | 25 |
| First president of the SCLC | 27 |
| First president of Tanzania | 27 |
| First president of S. Korea | 27 |
| First president of Mali | 23 |
| First president of Korea | 24 |
| First president of Indonesia | 28 |
| First president of Germany | 26 |
| First president of Gabon | 24 |
| First president of Angola | 25 |
| First premier of China | 22 |
| First pot contribution | 22 |
| First portrayer of Obi-Wan | 26 |
| First popular sound cartoon | 27 |
| First pope, in Catholicism | 26 |
| First political organization? | 29 |
| First player off the bench | 26 |
| First planet, alphabetically | 28 |
| First place on a marquee | 24 |
| First place of habitation | 25 |
| First place award perhaps | 26 |
| First pilot to exceed Mach 1 | 28 |
| First piece of trial evidence | 29 |
| First Physics Nobelist | 22 |
| First person, in Vienna | 23 |
| First person to fly a plane | 27 |
| First person to break Mach 1 | 28 |
| First person to be ribbed | 25 |
| First person present, e.g. | 26 |
| First person overseas? | 22 |
| First person on a ship? | 23 |
| First person indicator | 22 |
| First person in Vienna | 22 |
| First person in the Bible | 25 |
| First person in Potsdam | 23 |
| First person in Germany? | 24 |
| First person in Germany | 23 |
| First person in Frankfurt? | 26 |
| First person in France? | 23 |
| First person in France | 22 |
| First person in Berlin? | 23 |
| First person in Berlin | 22 |
| First person in Austria | 23 |
| First person in ancient Rome | 28 |
| First periods in H.S., often | 28 |
| First people from Manitoba | 26 |