| First White House golfer | 24 |
| First West German chancellor | 28 |
| First weather Satellites | 24 |
| First watch on the moon | 23 |
| First volume heading starter | 28 |
| First voice of Mickey Mouse | 27 |
| First Viscount Templewood | 25 |
| First Virginia in America | 25 |
| First video arcade game | 23 |
| First victim's namesakes | 28 |
| First victim of temptation | 26 |
| First victim of fratricide | 26 |
| First version of a film | 23 |
| First US vice president | 23 |
| First US space station | 22 |
| First unelected president | 25 |
| First UN secretary-general | 26 |
| First U.S. woman in space | 25 |
| First U.S. vice president | 25 |
| First U.S. spacewalk mission | 28 |
| First U.S. space traveler | 25 |
| First U.S. space station | 24 |
| First U.S. Postmaster General | 29 |
| First U.S. poet laureate | 24 |
| First U.S. multimillionaire | 27 |
| First U.S. color-TV maker | 25 |
| First U.S. color TV maker | 25 |
| First U.S. coed college | 23 |
| First U.S. chief justice | 24 |
| First U.S. ballistic missile | 28 |
| First U.N. Secretary General | 28 |
| First two-time Nobelist | 23 |
| First two-Nobel winner | 22 |
| First two in the first garden | 29 |
| First TV western series | 23 |
| First TV superstar Milton | 25 |
| First Triumvirate member | 24 |
| First Triple Crown winner | 25 |
| First Treasury secretary | 24 |
| First transplant recipient | 26 |
| First to Third, in Germany | 26 |
| First to take a ribbing | 23 |
| First to swim Lake Ontario | 26 |
| First to strike Caesar | 22 |
| First to see the sun, maybe | 27 |
| First to second, for one | 24 |
| First to move in chess | 22 |
| First to leave the blocks | 25 |
| First to break the tape | 23 |
| First to be admitted?: Abbr. | 28 |
| First to arrive, often: Abbr. | 29 |
| First tiller or killer | 22 |
| First three kinds of holes | 26 |
| First three colors of rainbow | 29 |
| First Thanksgiving locale | 25 |
| First Thanksgiving hosts | 24 |
| First term-limited pres. | 24 |
| First Tarzan portrayer | 22 |
| First T. Rex hit in 1970 | 24 |
| First symbol on a music line | 28 |
| First Syd Barrett solo album | 28 |
| First survey datum, often | 25 |
| First supersonic human | 22 |
| First Super Bowl rematch | 24 |
| First Super Bowl M.V.P. | 23 |
| First successful video game | 27 |
| First subway line in NYC | 24 |
| First subway line in N.Y.C. | 27 |
| First stroke of a round | 23 |
| First strip to win a Pulitzer | 29 |
| First stomach of a cow | 22 |
| First stock sale, for short | 27 |
| First Stephen King novel | 24 |
| First step toward nirvana | 25 |
| First step in division? | 23 |
| First step in a series | 22 |
| First step in a progression | 27 |
| First step in a hairdo | 22 |
| First State's capital | 25 |
| First stage of a study | 22 |
| First stabber of Caesar | 23 |
| First st. with women voters | 27 |
| First spoken word in Genesis | 28 |
| First spin: mixed fruit | 23 |
| First South Korean president | 28 |
| First sound of silence? | 23 |
| First sound of impact? | 22 |
| First sound of an MGM movie | 27 |
| First sound in an SOS call | 26 |
| First sound in an MGM movie | 27 |
| First sound in an M-G-M film | 28 |
| First song on an album | 22 |
| First Son of the '80s | 25 |
| First six-decade hockey pro | 27 |
| First site of Olympic games | 27 |
| First sign, astrologically | 26 |
| First sign of the zodiac | 24 |
| First showing of a film | 23 |
| First shots in billiards | 24 |
| First shepherd in the Bible | 27 |