| One side in a 1960s civil war | 29 |
| One side in "The War of the Worlds" | 45 |
| One side | 8 |
| One sib | 7 |
| One Siamese twin | 16 |
| One shy of a unanimous verdict | 30 |
| One showing signs of a cold | 27 |
| One showing promise? | 20 |
| One showing promise | 19 |
| One showing pleasure | 20 |
| One showing empathy | 19 |
| One showing diners to their tables | 34 |
| One showing curiosity | 21 |
| One showing boredom | 19 |
| One show | 8 |
| One shouldn't lie under it | 30 |
| One shouldn't have a big head | 33 |
| One should stay on the right side of this limb | 46 |
| One should hesitate when seeing this | 36 |
| One should have three a day | 27 |
| One shot, perhaps | 17 |
| One shot in a cliffhanger | 25 |
| One shot a lot | 14 |
| One short of breath | 19 |
| One shopping for wool sweaters? | 31 |
| One shooting the bull? | 22 |
| One shooting the breeze? | 24 |
| One shooting out on a golf course | 33 |
| One shooting from the mouth? | 28 |
| One shivering atop Mount Ararat? | 32 |
| One shifted to a new post | 25 |
| One sheet to the wind? | 22 |
| One shedding tears | 18 |
| One sharing top billing | 23 |
| One sharing the wealth? | 23 |
| One sharing the billboard | 25 |
| One sharing living space | 24 |
| One sharing Iranian money? | 26 |
| One sharing an apartment | 24 |
| One sharing a bunk bed, maybe | 29 |
| One shadowing an outgoing president? | 36 |
| One sexting, maybe | 18 |
| One settling elsewhere | 22 |
| One settling down | 17 |
| One settling a score, say | 25 |
| One settling a score, in olden days | 35 |
| One settling a score | 20 |
| One settling a bill | 19 |
| One setting a new high | 22 |
| One set of gifts in "The 12 Days of Christmas" ... as suggested by the circled squares? | 97 |
| One set for a future wedding? | 29 |
| One set against | 15 |
| One serving well | 16 |
| One serving the soup | 20 |
| One serving the lord | 20 |
| One serving out a term | 22 |
| One serving or aiding | 21 |
| One serving a six-yr. term | 26 |
| One serving a sentence | 22 |
| One serving a long term | 23 |
| One serve, one point | 20 |
| One seriously straying from the flock? | 38 |
| One seriously into Civil War history, maybe | 43 |
| One sent out for information | 28 |
| One sensitive to light | 22 |
| One sensitive to beauty: var. | 29 |
| One sense, figuratively | 23 |
| One sending cybernotes | 22 |
| One sending a poltergeist via FedEx? | 36 |
| One sending a letter | 20 |
| One selling TV time, e.g. | 25 |
| One selling seats | 17 |
| One selling green cheese? | 25 |
| One selling bottles of sugar and arsenic, say | 45 |
| One seen with Lennon | 20 |
| One seen streaking | 18 |
| One seen playing with a beachball | 33 |
| One seen on "60 Minutes" | 34 |
| One seen in Häagen-Dazs | 26 |
| One seen in films | 17 |
| One seen in a store dish | 24 |
| One seen in a shower | 20 |
| One seen at trackside | 21 |
| One seeking what's rightfully his or hers | 45 |
| One seeking to gain time | 24 |
| One seeking to escape reality | 29 |
| One seeking to catch some rays? | 31 |
| One seeking the way? | 20 |
| One seeking some anthers | 24 |
| One seeking signs of life?: Abbr. | 33 |
| One seeking signs of life? | 26 |
| One seeking results | 19 |
| One seeking repayment | 21 |
| One seeking redemption, maybe | 29 |
| One seeking political favors | 28 |
| One seeking political asylum | 28 |
| One seeking Mr. Right? | 22 |
| One seeking justice for the peace? | 34 |
| One seeking intelligence | 24 |
| One seeking gratification | 25 |