| Second name in inventions | 25 |
| Second name in inventors | 24 |
| Second name on the bill | 23 |
| Second name? | 12 |
| Second nature | 13 |
| Second New Testament book | 25 |
| Second notation at the bottom of a letter | 41 |
| Second notes | 12 |
| Second notes in diminished chords, in music | 43 |
| Second notes of the scale | 25 |
| Second nursery rhyme tumbler | 28 |
| Second O of O-O-O | 17 |
| Second O of OOO | 15 |
| Second occupation | 17 |
| Second of 12: Abbr. | 19 |
| Second of 24 | 12 |
| Second of a Caesarean trio | 26 |
| Second of a cereal trio | 23 |
| Second of a game trio | 21 |
| Second of a historical trio | 27 |
| Second of a Latin 101 trio | 26 |
| Second of a Latin I trio | 24 |
| Second of a Latin paradigm | 26 |
| Second of a Latin trio | 22 |
| Second of a musical tetralogy | 29 |
| Second of a pair | 16 |
| Second of a pair of letters swapped six times in this puzzle's theme entries | 80 |
| Second of a poetic trio | 23 |
| Second of a restless pair | 25 |
| Second of a Roman's three names | 35 |
| Second of a series | 18 |
| Second of a word-processing pair | 32 |
| Second of all | 13 |
| Second of all? | 14 |
| Second of April? | 16 |
| Second of Ben Cartwright's sons | 35 |
| Second of billions | 18 |
| Second of four at college | 25 |
| Second of January | 17 |
| Second of six for Henry VIII | 28 |
| Second of six? | 14 |
| Second of the five stages of grief | 34 |
| Second of the plagues of Egypt | 30 |
| Second of the sextet | 20 |
| Second of the three Super Bowls in which Joe Montana was the MVP | 64 |
| Second of three | 15 |
| Second of three black keys | 26 |
| Second of three kids in actress Charlotte's family? | 55 |
| Second of three virtues | 23 |
| Second of three words in West Point's motto | 47 |
| Second of three X's | 23 |
| Second of three X's, perhaps | 32 |
| Second of two | 13 |
| Second of two bell sounds | 25 |
| Second of two groups that may come in handy for this puzzle? | 60 |
| Second of two mentioned | 23 |
| Second of two photos, perhaps | 29 |
| Second of two pieces of fire truck equipment | 44 |
| Second of two sections | 22 |
| Second of two spouses? | 22 |
| Second offer, as on eBay | 24 |
| Second only to Bonds in all-time homers | 39 |
| Second opening | 14 |
| Second opening in a sock | 24 |
| Second opening? | 15 |
| Second option's lead-in | 27 |
| Second or fourth wife of Henry VIII | 35 |
| Second or home | 14 |
| Second or human | 15 |
| Second or sixth in a series | 27 |
| Second or sixth president | 25 |
| Second or tenth, in a way | 25 |
| Second or third showing | 23 |
| Second or third showing, e.g. | 29 |
| Second or third, for instance | 29 |
| Second order of angels | 22 |
| Second Oscar/Tony/Emmy/Grammy actress | 37 |
| Second page in a chapter | 24 |
| Second part | 11 |
| Second part of a kid's game | 31 |
| Second part of a Latin conjugation | 34 |
| Second part of a play | 21 |
| Second part of a quip | 21 |
| Second part of a sage thought | 29 |
| Second part of a snicker | 24 |
| Second part of a three-part command | 35 |
| Second part of an act | 21 |
| Second part of assembly instructions, perhaps | 45 |
| Second part of quote | 20 |
| Second part of the description | 30 |
| Second part of the headline | 27 |
| Second part of the joke | 23 |
| Second part of the message | 26 |
| Second part of the question | 27 |
| Second part of the quip | 23 |
| Second part of the quote | 24 |
| Second part of the riddle | 25 |
| Second part of what's hidden | 32 |
| Second passage: Part II | 23 |
| Second passage: Part III | 24 |