| The Simpsons' Snowball II, e.g. | 35 |
| The six of "Little Nellie Kelly" | 42 |
| The skin is the largest one in humans | 37 |
| The Skipper's plan, on paper | 32 |
| The skull reminded Hamlet that he ___ | 37 |
| The slam-dunker's violation? | 32 |
| The slightest amount, informally | 32 |
| The smallest of three famous ships | 34 |
| The smile on an email happy face | 32 |
| The Smith's "How ___ Is Now?" | 43 |
| The Smith's "Louder ___ Bombs" | 44 |
| The Smiths' "Girlfriend in a ___" | 47 |
| The Smothers Brothers and others | 32 |
| The Snake R. forms part of its border | 37 |
| The Snake River snakes through it | 33 |
| The sneaker manufacturer started ... | 36 |
| The so-called "blue marble" | 37 |
| The so-called "potted physician" | 42 |
| The so-called "single currency" | 41 |
| The so-called "Tenth Muse" | 36 |
| The so-called Island of the Gods | 32 |
| The socially lost, in stereotypes | 33 |
| The software installer brought ... | 34 |
| The son on "Sanford and Son" | 38 |
| The song you and I put on the back of the single | 48 |
| The sopranino is the smallest one | 33 |
| The sound of "Silence!" | 33 |
| The sound of honking and coughing all in one? | 45 |
| The sound of rustling gift paper set to music? | 46 |
| The Sounds song inspired by Pat Benatar? | 40 |
| The sour taste of Robespierre's tenure? | 43 |
| The South, in the Civil War: Abbr. | 34 |
| The Spanish ___ (1588 invasion fleet) | 37 |
| The Spartans of the Big Ten: Abbr. | 34 |
| The spendthrift scuba diver usually ___ | 39 |
| The spice of life, so it's said | 35 |
| The sport of rowing racing shells | 33 |
| The sport of shooting, in Soissons | 34 |
| The Spy Who Came In From the Cold | 33 |
| The squares of "three squares" | 40 |
| The squeaky wheel gets the grease, but also... | 46 |
| The St. Lawrence R. flows through it | 36 |
| The Stars may play the Blues in it, briefly | 43 |
| The stars of the Stars and Stripes | 34 |
| The start of the four theme entries, collectively | 49 |
| The State Department on a nice day? | 35 |
| The State Department, informally | 32 |
| The state of falling into disuse | 32 |
| The statue of David in Florence, e.g. | 37 |
| The Statue of Liberty's garb | 32 |
| The Steelers won its title in 2011 (abbr.) | 42 |
| The Step Brothers' dance genre | 34 |
| The Stern School of Business is part of it: Abbr. | 49 |
| The Steve Miller Band "Wide ___" | 42 |
| The still-hungry baby sitter ___ | 32 |
| The still-hungry clumsy fellow ___ | 34 |
| The still-hungry eager beaver ___ | 33 |
| The still-hungry sucker ___ the bait | 36 |
| The story of the aftermath of Oceanic Flight 815 | 48 |
| The story of the one that got away, e.g. | 40 |
| The Strait of Messina separates it from Italy | 45 |
| The Strait of Otranto connects to it | 36 |
| The Street Singer's theme song | 34 |
| The stressed-out photographer __ | 32 |
| The String Cheese Incident, e.g. | 32 |
| The Strokes "Barely ___" | 34 |
| The study of great plays at the plate? | 38 |
| The study of Muppet news flashes? | 33 |
| The study of the Springfield Isotopes? | 38 |
| The stuff of many postcard photos | 33 |
| The stuff some soldiers are made of | 35 |
| The Stylistics' "___ By Golly, Wow" | 49 |
| The Suez Crisis led to his resignation | 38 |
| The Sultan of ___ (Ruth's moniker) | 38 |
| The sun and its revolving spheres | 33 |
| The Sun and Mercury are in it: Abbr. | 36 |
| The sun causes them during photoptarmosis | 41 |
| The sun gives comfort to top pilots | 35 |
| The sun peeking through the clouds, to some | 43 |
| The Sun's topless model feature | 35 |
| The Sun, The Moon or The Emperor | 32 |
| The Sundance Kid's girl and others | 38 |
| The Sundance Kid, for Harry Longabaugh | 38 |
| The sunny side, in sunny side up | 32 |
| The Sunset Tower Hotel's style | 34 |
| The Super Bowl, to a football fan | 33 |
| The supermarket has bags and bags of it | 39 |
| The Supreme Court outlawed it in '35 | 40 |
| The Supremes' "___ Symphony" | 42 |
| The Supremes' "_____ a Symphony" | 46 |
| The surf of surf and turf, perhaps | 34 |
| The swirl at the bottom of the tub, e.g. | 40 |
| The symbol for the Roman god Mars represents it | 47 |
| The symphony conductor got busted for ___ | 41 |
| The Szczecin Lagoon is an extension of its mouth | 48 |
| The T in ''GWTW'' | 33 |
| The T in GTL, on "Jersey Shore" | 41 |
| The T-Birds in ''Grease,'' e.g. | 47 |
| The tailor's response, part 1 | 33 |
| The talkative coffee shop worker ... | 36 |