| Successor to Koizumi as prime minister of Japan | 47 |
| Successor to Marshall on the Supreme Court | 42 |
| Successor to Powell on the Supreme Court | 40 |
| Successor to the game Ruff and Honours | 38 |
| Successor to the Pan-American Union | 35 |
| Successor to the Prophet, in Islam | 34 |
| Succinct description of the battle at el-Alamein? | 49 |
| Succulent African shrub popular as a bonsai | 43 |
| Succulent containing a medicinal gel | 36 |
| Succulent in some trendy bottled beverages | 42 |
| Succulent once used to treat tuberculosis | 41 |
| Succulent, spiny-leafed, medicinal plant | 40 |
| Succulents commonly used in the beauty business | 47 |
| Succumbs to interrogation, perhaps | 34 |
| Sucked dry, as of one's fortune | 35 |
| Sucker who's broken out in a cold sweat? | 44 |
| Sucrose polyester, more familiarly | 34 |
| Sudanese activist/athlete Manute who died in 2010 | 49 |
| Sudanese cable channel for kids? | 32 |
| Sudanese president ___ Hassan al-Bashir | 39 |
| Sudbury-born game show host, Alex ____ | 38 |
| Sudden assembly that some find entertaining | 43 |
| Sudden increases in some fraternal organizations? | 49 |
| Sudden light seen through the clouds | 36 |
| Sudden restriction on an activity | 33 |
| Sudden, violent activity or feeling | 35 |
| Suddenly became attentive, with "up" | 46 |
| Suddenly becoming extremely paranoid | 36 |
| Suddenly intensify, with "up" | 39 |
| Suddenly leave one's seat on a plane? | 41 |
| Suddenly look interested, with "up" | 45 |
| Suddenly looked interested, with "up" | 47 |
| Suddenly occurs to, with "on" | 39 |
| Suddenly reacts to a strong wind, as a window | 45 |
| Suddenly stops working, with "up" | 43 |
| Suddenly talk about a new subject | 33 |
| Suddenly thrusted, as with a sword | 34 |
| Suddenly, for Jimmy things never ___ | 36 |
| Sudermann's "___ Hohe Lied" | 41 |
| Sudermann's "___ Sorge" | 37 |
| Sudoku's cross-sums relative | 32 |
| Sue at Chicago's Field Museum, e.g. | 39 |
| Sue Grafton's '-- for Alibi' | 40 |
| Sue Grafton's '-- for Evidence' | 43 |
| Sue Grafton's '-- for Innocent' | 43 |
| Sue Grafton's '-- for Noose' | 40 |
| Sue Grafton's '-- for Outlaw' | 41 |
| Sue Grafton's '-- for Quarry' | 41 |
| Sue Grafton's '-- for Undertow' | 43 |
| Sue Grafton's 'N Is for --' | 39 |
| Sue Grafton's "--- for Evidence" | 46 |
| Sue Grafton's "O is for ---" | 42 |
| Sue Grafton's "__ for Corpse" | 43 |
| Sue Grafton's "__ for Innocent" | 45 |
| Sue Grafton's "__ for Lawless" | 44 |
| Sue Grafton's "__ for Outlaw" | 43 |
| Sue Grafton's "___ for Alibi" | 43 |
| Sue Grafton's "___ for Corpse" | 44 |
| Sue Grafton's "___ for Evidence" | 46 |
| Sue Grafton's "___ for Innocent" | 46 |
| Sue Grafton's "___ for Killer" | 44 |
| Sue Grafton's "___ For Lawless" | 45 |
| Sue Grafton's "___ for Noose" | 43 |
| Sue Grafton's "___ for Outlaw" | 44 |
| Sue Grafton's "___ For Owl" | 41 |
| Sue Grafton's "___ for Ricochet" | 46 |
| Sue Grafton's Kinsey Millhone, e.g. | 39 |
| Sue Grafton's second Kinsey Millhone novel | 46 |
| Sue Miller work (with "The") | 38 |
| Sue Sylvester über-fan, probably | 35 |
| Sued party in a legal case: Abbr. | 33 |
| Suffer a "brain cramp" | 32 |
| Suffer a blow to the head, perhaps | 34 |
| Suffer a humiliating loss, in slang | 35 |
| Suffer a public embarrassment, maybe | 36 |
| Suffer a spectacular fall from grace | 36 |
| Suffer an embarrassing defeat, slangily | 39 |
| Suffer from extra exercise, maybe | 33 |
| Suffer ignominious defeat, in slang | 35 |
| Suffer one-day losses in the market, say | 40 |
| Suffer the effects of a haymaker | 32 |
| Suffer through the stench, maybe | 32 |
| Suffered a blow to one's pride | 34 |
| Suffered a financial setback, slangily | 38 |
| Suffered from homesickness, e.g. | 32 |
| Suffered from unaccustomed exercise, perhaps | 44 |
| Suffered humiliation, informally | 32 |
| Suffered ignominious failure, in slang | 38 |
| Sufferer of a crushing defeat in 1936 | 37 |
| Sufferer of an infamous bad hair day | 36 |
| Suffering a losing streak, in poker | 35 |
| Suffering a loss, without a doubt? | 34 |
| Suffering from "I" strain? | 36 |
| Suffering from insomnia, perhaps | 32 |
| Suffering from laryngitis, perhaps | 34 |
| Suffering from spring fever, maybe | 34 |
| Suffering from too much drink, perhaps | 38 |
| Suffering from too much exercise | 32 |
| Suffering's partner, in court | 33 |
| Suffers through a boring meeting, maybe | 39 |