| Space station launched by the Soviets | 37 |
| Space station that crashed to Earth in 2001 | 43 |
| Space station that fell to Earth in 2001 | 40 |
| Space station that had a supply of vodka | 40 |
| Space station that operated on Moscow time | 42 |
| Space station whose final module was Priroda | 44 |
| Space that ought to be in ZZ Topoly? | 36 |
| Space-saving abbr. hidden in four puzzle answers | 48 |
| Space-signal searcher's acronym | 35 |
| Spacecraft on a planet's surface | 36 |
| Spacecraft that began orbiting Saturn in 2004 | 45 |
| Spacehog "At Least I Got ___" | 39 |
| Spacehog debut "Resident ___" | 39 |
| Spacehog's debut "Resident ___" | 45 |
| Spacek of ''Crimes of the Heart'' | 49 |
| Spacek of "Coal Miner's Daughter" | 47 |
| Spacek of "Crimes of the Heart" | 41 |
| Spacek's "___ Man" | 32 |
| Spacely Space Sprockets employee | 32 |
| Spaces between lines, in printing | 33 |
| Spaces between objects or points | 32 |
| Spaces just under a bird's eyes | 35 |
| Spaceship that used the Moscow time zone | 40 |
| Spacewalks and moonwalks, briefly | 33 |
| Spacey of "American Beauty" | 37 |
| Spacey's "Superman Returns" role | 46 |
| Spacey/Bening Oscar-winning picture | 35 |
| Spade of "The Maltese Falcon" | 39 |
| Spades bid worth 100 points if successful | 41 |
| Spades in a four-spades bridge contract, say | 44 |
| Spaghetti makers' implements | 32 |
| Spaghetti sauce seasoning, sometimes | 36 |
| Spaghetti that smells and tastes terrible? | 42 |
| Spaghetti topping desired by all? | 33 |
| Spaghetti western composer Morricone | 36 |
| Spaghetti western director Leone | 32 |
| Spaghetti western director Sergio | 33 |
| Spaghetti western film director Leone | 37 |
| Spahn's former companion in Boston | 38 |
| Spain "___ and Prayed" | 32 |
| Spain and Portugal's peninsula | 34 |
| Spain's 1973 Eurovision Song Contest entry | 46 |
| Spain's capital city, as a sum? | 35 |
| Spain's claim to fame put to shame in 1588 | 46 |
| Spain's Juan Carlos, for one | 32 |
| Spain's most voluminous river | 33 |
| Spain's Queen Victoria Eugenia, familiarly | 46 |
| Spain's San Isidro and others | 33 |
| Spain's second-longest river | 32 |
| Spain's traditional currency | 32 |
| Spain's Victoria Eugenia, familiarly | 40 |
| Spandau prison's last inmate | 32 |
| Spaniard who wrote "Dark Wedding": 1943 | 49 |
| Spaniard's "I love" | 33 |
| Spaniard's "these" | 32 |
| Spaniard's foe in the Greater Antilles | 42 |
| Spanish ''ayes'' | 32 |
| Spanish "no son," translated | 38 |
| Spanish 101 alternative to "estás" | 47 |
| Spanish author: 1879–1930 | 32 |
| Spanish blue, look at, young fox | 32 |
| Spanish center for the L.A. Lakers Gasol | 40 |
| Spanish cession in the Spanish-American War | 43 |
| Spanish city and province on the Mediterranean | 46 |
| Spanish city at the foot of Sierra Nevada | 41 |
| Spanish city for which sherry is named | 38 |
| Spanish city from which sherry takes it name | 44 |
| Spanish city known for its aqueduct | 35 |
| Spanish city that gave sherry its name | 38 |
| Spanish city that's the capital of Asturias | 47 |
| Spanish city where Seneca was born | 34 |
| Spanish city where the bulls run | 32 |
| Spanish city with a Guggenheim Museum | 37 |
| Spanish classical guitarist Andrés | 37 |
| Spanish classical guitarist Andrés | 41 |
| Spanish coin first minted in 1869 | 33 |
| Spanish coin replaced by the euro | 33 |
| Spanish conquistadora ___ de Suárez | 38 |
| Spanish contraction meaning "of the" | 46 |
| Spanish currency before the euro | 32 |
| Spanish dancers' accessories | 32 |
| Spanish device for capital punishment | 37 |
| Spanish dialect that's now standard | 39 |
| Spanish discoverer of the Pacific, 1513 | 39 |
| Spanish dish of meat and vegetables | 35 |
| Spanish dish with rice and saffron | 34 |
| Spanish explorer of Upper California | 36 |
| Spanish explorer who discovered the Grand Canyon | 48 |
| Spanish explorer who discovered the Mississippi | 47 |
| Spanish explorer ___ Bautista de Anza | 37 |
| Spanish fashion designer Antonio | 32 |
| Spanish fashion designer Rabanne | 32 |
| Spanish football powerhouse, familiarly | 39 |
| Spanish for 'I love you' | 32 |
| Spanish for "little cake" | 35 |
| Spanish for "that girl" | 33 |
| Spanish form of "to be" | 33 |
| Spanish guitarist ______ De Lucia | 33 |
| Spanish guitarist-composer: 1778-1839 | 37 |
| Spanish hero in accident? (with "El") | 47 |