| Substance in acid tests | 23 |
| Substance in a visual display unit | 34 |
| Substance in a vein | 19 |
| Substance in a seam | 19 |
| Substance in a chemistry experiment | 35 |
| Substance giving red wine an astringent taste | 45 |
| Substance from which the universe was created, to some | 54 |
| Substance from which the universe was created | 45 |
| Substance from madder | 21 |
| Substance found on unhygienic males | 35 |
| Substance found in flour | 24 |
| Substance for washing textiles | 30 |
| Substance for smelting | 22 |
| Substance for slippery wrestling | 32 |
| Substance for sculptures | 24 |
| Substance for making beads | 26 |
| Substance for etching | 21 |
| Substance for dilating pupils | 29 |
| Substance for a violin bow | 26 |
| Substance for a leaky radiator | 30 |
| Substance for a hair-raising experience? | 40 |
| Substance falsely tied to food poisoning | 40 |
| Substance essential to life | 27 |
| Substance derived from starch | 29 |
| Substance contained in many vitamin C supplements | 49 |
| Substance consisting of giant molecules | 39 |
| Substance companion | 19 |
| Substance checker: Abbr. | 24 |
| Substance causing a global catastrophe in "Cat's Cradle" | 70 |
| Substance called a pesticide by the E.P.A. | 42 |
| Substance added to paint and varnish | 36 |
| Substance abuse support group | 29 |
| Substance | 9 |
| Subst. for unnamed things | 25 |
| Subst. for the rest of the list | 31 |
| Subst. for some names | 21 |
| Subst. | 6 |
| Subspecies especially adapted to their environments | 51 |
| Subspecialty | 12 |
| Subsoil, for a flower | 21 |
| Subsoil layer | 13 |
| Subsoil | 7 |
| Subsists (on) | 13 |
| Subsists | 8 |
| Subsistence | 11 |
| Subsisted (on) | 14 |
| Subsisted | 9 |
| Subsist on next to nothing | 26 |
| Subsist on field rations? | 25 |
| Subsist (on) | 12 |
| Subsist | 7 |
| Subsidy, e.g. | 13 |
| Subsidy | 7 |
| Subsidizes | 10 |
| Subsidized housing in Riyadh? | 29 |
| Subsidized grad student | 23 |
| Subsidize | 9 |
| Subsiding, with "down" | 32 |
| Subsiding (with "down") | 33 |
| Subsiding | 9 |
| Subsidies | 9 |
| Subsidiary theorem | 18 |
| Subsidiary staffers | 19 |
| Subsidiary rule | 15 |
| Subsidiary route | 16 |
| Subsidiary propositions | 23 |
| Subsidiary proposition in a proof | 33 |
| Subsidiary proposition | 22 |
| Subsidiary office | 17 |
| Subsidiary of Whirlpool | 23 |
| Subsidiary of Sony | 18 |
| Subsidiary of Heinz | 19 |
| Subsidiary of Hallmark | 22 |
| Subsidiary news piece | 21 |
| Subsidiary member of a firm | 27 |
| Subsidiary meaning | 18 |
| Subsidiary math theorem | 23 |
| Subsidiary location | 19 |
| Subsidiary dinner course | 24 |
| Subsidiary building | 19 |
| Subsidiary | 10 |
| Subsides, as the tide | 21 |
| Subsides gradually (with "down") | 42 |
| Subsides gradually | 18 |
| Subsides | 8 |
| Subsided, with "down" | 31 |
| Subsided gradually | 18 |
| Subsided (with "down") | 32 |
| Subsided (with ''down'') | 40 |
| Subsided | 8 |
| Subside, with "up" | 28 |
| Subside, with "over" | 30 |
| Subside, with "down" | 30 |
| Subside, as the sea | 19 |
| Subside | 7 |
| Subset of the complex numbers | 29 |
| Subservient subordinate, perhaps | 32 |
| Subservient response | 20 |
| Subservient one | 15 |
| Subservient | 11 |