| Seller of seashells by the seashore | 35 |
| Seller of slushies on "The Simpsons" | 46 |
| Seller of SOMMARVIND beach accessories | 38 |
| Seller of space or time, for short | 34 |
| Seller of Squishees on "The Simpsons" | 47 |
| Seller of tofu dogs on "The Simpsons" | 47 |
| Sellers costar in the Pink Panther films | 40 |
| Sellers film, with "The" | 34 |
| Selling 500,000 copies, as a music CD | 37 |
| Selling point for a house on the coast | 38 |
| Selling point in cigarette ads, once | 36 |
| Selling point of a home on the Hudson, say | 42 |
| Selling point of many vacation homes | 36 |
| Selling point on some cigarette packages | 40 |
| Selling site with a Half.com division | 37 |
| Selma and Patty's younger sister | 36 |
| Selma or Patty, vis-á-vis Bart and Lisa | 42 |
| Selwyn portrayer Don of "Cocoon" | 42 |
| Selznick called it "Just a façade" | 47 |
| Semi driven by grunge-rocker Courtney? | 38 |
| Semi-aquatic and extremely scary beast | 38 |
| Semi-frozen drink similar to an Italian ice | 43 |
| Semi-serious "I understand" | 37 |
| Semiautobiographical Bob Fosse film | 35 |
| Semicircular basin in a mountain | 32 |
| Semicircular canal count per ear | 32 |
| Semicircular canals' locales | 32 |
| Semicircular moldings at column bases | 37 |
| Semicircular recess in Roman architecture | 41 |
| Seminal 1962 book on the environment | 36 |
| Seminal parts for a barbershop quartet? | 39 |
| Seminal punk label founded by Black Flag | 40 |
| Seminal punk rock label operated by Black Flag | 46 |
| Seminal short-story collection by Asimov | 40 |
| Seminole rival, in college sports | 33 |
| Seminole War major with counties named after him | 48 |
| Seminole War officer for whom a county was named | 48 |
| Semis happen near the end of them | 33 |
| Semisoft cheese with an orange rind | 35 |
| Semisonic "Great Divide" song (Abbr.) | 47 |
| Semisonic song off "Great Divide" | 43 |
| Semitic language written with the Roman alphabet | 48 |
| Semiweekly Martha's Vineyard newspaper | 42 |
| Sen. Bayh's senior counterpart | 34 |
| Sen. Biden represented it: Abbr. | 32 |
| Sen. Gaylord ___, who originated Earth Day | 42 |
| Sen. Gillibrand represents it: Abbr. | 36 |
| Sen. Lieberman's affiliation, now | 37 |
| Sen. Lieberman's classification | 35 |
| Sen. McGovern's birthplace in S.D. | 38 |
| Sen. Schumer represents it: Abbr. | 33 |
| Sen. Sessions's state: Abbr. | 32 |
| Sen. Weicker's colleague from Conn. | 39 |
| Senate Agriculture Committee head | 33 |
| Senate and people of Rome: Abbr. | 32 |
| Senate Foreign Relations Committee chair, 2003-07 | 49 |
| Senate GOP leader between Dole and Frist | 40 |
| Senate Judiciary Committee chairman | 35 |
| Senate Majority Leader after Frist | 34 |
| Senate majority leader before Reid | 34 |
| Senate majority leader before Trent Lott | 40 |
| Senate majority leader since 2007 | 33 |
| Senate Majority Whip before Reid | 32 |
| Senate minority leader McConnell | 32 |
| Senate Republican leader before Frist | 37 |
| Senate situation requiring the Vice President | 45 |
| Senate Watergate committee chair Sam | 36 |
| Senate word that only sounds exciting | 37 |
| Senate's David and comedy's Richard | 43 |
| Senate's Democratic Chief Deputy Whip | 41 |
| Senator aboard "Discovery" | 36 |
| Senator Alexander from Tennessee | 32 |
| Senator Christopher from Connecticut | 36 |
| Senator Feinstein of California | 32 |
| Senator for 47 straight years, a Senate record | 46 |
| Senator for whom an IRA is named | 32 |
| Senator formerly on "SNL" | 35 |
| Senator from California from 1969 to 1993 | 41 |
| Senator from Kansas or North Carolina | 37 |
| Senator Jake who flew on space shuttle Discovery | 48 |
| Senator Jon of non-factual statements | 37 |
| Senator or congressman, for short | 33 |
| Senator Phil who co-authored a budget act | 41 |
| Senator Sam of the Watergate hearings | 37 |
| Senator Sam who investigated Watergate | 38 |
| Senator Sanders of Vt., on ballots | 34 |
| Senator Schumer's predecessor | 33 |
| Senator Scott from South Carolina | 33 |
| Senator that gave his name to a federal aid grant | 49 |
| Senator Thurmond who left office at age 100 | 43 |
| Senator who gave Golden Fleece awards | 37 |
| Senator who isn't a strict schoolteacher | 44 |
| Senator who served on the USS Gridley | 37 |
| Senator who succeeded John Stennis | 34 |
| Senator's adjective for a colleague | 39 |
| Senator/campaigner Joe from Delaware | 36 |
| Senators and representatives, for short | 39 |
| Senators Bunning, DeMint, Risch, and Webb | 41 |
| Senators hear it before facing off | 34 |
| Senators' advantage in Ottawa | 33 |