| Second film in a 2000s horror franchise | 39 |
| Second generation Japanese-American | 35 |
| Second half of a mountaineer's trip | 39 |
| Second half of a rhyming Beatles title | 38 |
| Second half of things we all memorized | 38 |
| Second highest in a family of instruments | 41 |
| Second highest, in a family of instruments | 42 |
| Second in a series of sharp turns | 33 |
| Second in a series of Web postings | 34 |
| Second in command in the state: Abbr. | 37 |
| Second Israeli ambassador to the U.S. | 37 |
| Second Israeli ambassador to U.S. | 33 |
| Second Jimi Hendrix Experience album | 36 |
| Second largest "Great Lake" | 37 |
| Second largest city in Nicaragua | 32 |
| Second largest city in the Czech Republic | 41 |
| Second largest Islam denomination | 33 |
| Second largest island in the world | 34 |
| Second largest of the Great Lakes | 34 |
| Second largest of the Great Lakes | 33 |
| Second largest retailer in the U.S. | 35 |
| Second largest theater chain in the U.S. | 40 |
| Second letter of the Greek alphabet | 35 |
| Second look, on "Monday Night Football" | 49 |
| Second Lt.'s Navy equivalent | 32 |
| Second miss in a hangman game, often | 36 |
| Second most common Korean surname | 33 |
| Second most populous Central American city | 42 |
| Second most populous city in Michigan | 37 |
| Second most populous city in Yemen | 34 |
| Second most populous continent: Abbr. | 37 |
| Second most populous Oklahoma city | 34 |
| Second notation at the bottom of a letter | 41 |
| Second notes in diminished chords, in music | 43 |
| Second of a Roman's three names | 35 |
| Second of a word-processing pair | 32 |
| Second of Ben Cartwright's sons | 35 |
| Second of the five stages of grief | 34 |
| Second of three words in West Point's motto | 47 |
| Second of three X's, perhaps | 32 |
| Second of two pieces of fire truck equipment | 44 |
| Second only to Bonds in all-time homers | 39 |
| Second or fourth wife of Henry VIII | 35 |
| Second Oscar/Tony/Emmy/Grammy actress | 37 |
| Second part of a Latin conjugation | 34 |
| Second part of a three-part command | 35 |
| Second part of assembly instructions, perhaps | 45 |
| Second part of what's hidden | 32 |
| Second person appearing in the Bible | 36 |
| Second person plural, in the South | 34 |
| Second person to make a solo transatlantic flight | 49 |
| Second photo in a testimonial ad | 32 |
| Second photo in some testimonial ads | 36 |
| Second pope, following St. Peter | 32 |
| Second president of the Weimar Republic | 39 |
| Second president to be assassinated | 35 |
| Second Republic of Texas president | 34 |
| Second second thought, for short | 32 |
| Second section or installment, perhaps | 38 |
| Second sign of a highway headache | 33 |
| Second sign on the music store door? | 36 |
| Second smallest continent, by size (abbr.) | 42 |
| Second song on "Beatles '65" | 42 |
| Second spin: close, but no cigar | 32 |
| Second step in a three-step cleansing process | 45 |
| Second summer blockbuster film, e.g.: Abbr. | 43 |
| Second Super Bowl won by the Redskins | 37 |
| Second track on "Beatles '65" | 43 |
| Second trimester test, for short | 32 |
| Second vegetable course in a capital meal? | 42 |
| Second wife in "The Good Earth" | 41 |
| Second wife, to the hubby's kids | 36 |
| Second word in "Bohemian Rhapsody" | 44 |
| Second word in "The Raven" | 36 |
| Second word in a classic Whitman poem | 37 |
| Second word in a Shakespeare title | 34 |
| Second word in many a fairy tale | 32 |
| Second word of "A Hard Day's Night" | 49 |
| Second word of "A Tale of Two Cities" | 47 |
| Second word of "Candle in the Wind" | 45 |
| Second word of "Jabberwocky" | 38 |
| Second word of "La Marseillaise" | 42 |
| Second word of "Mr. Roboto" | 37 |
| Second word of "Mrs. Robinson" | 40 |
| Second word of "The Raven" | 36 |
| Second word of a Brian Hyland song title | 40 |
| Second word of a Hemingway title | 32 |
| Second word of a military command | 33 |
| Second word of a trochaic 13th-century hymn | 43 |
| Second word of fairy tale openings | 34 |
| Second word of Kansas' motto | 32 |
| Second word of many a fairy tale | 32 |
| Second word of the American national anthem | 43 |
| Second word of the U.S. national anthem | 39 |
| Second word shouted on January 1, often | 39 |
| Second ___ (man's seventh age) | 34 |
| Second-best of the Hank Williamses | 34 |
| Second-biggest bird after the ostrich | 37 |
| Second-biggest movie hit of 1978 | 32 |
| Second-brightest object in the night sky | 40 |