| Subsistence | 11 |
| Subsists | 8 |
| Subsists (on) | 13 |
| Subsoil | 7 |
| Subsoil layer | 13 |
| Subsoil, for a flower | 21 |
| Subspecialty | 12 |
| Subspecies especially adapted to their environments | 51 |
| Subst. | 6 |
| Subst. for some names | 21 |
| Subst. for the rest of the list | 31 |
| Subst. for unnamed things | 25 |
| Substance | 9 |
| Substance abuse support group | 29 |
| Substance added to paint and varnish | 36 |
| Substance called a pesticide by the E.P.A. | 42 |
| Substance causing a global catastrophe in "Cat's Cradle" | 70 |
| Substance checker: Abbr. | 24 |
| Substance companion | 19 |
| Substance consisting of giant molecules | 39 |
| Substance contained in many vitamin C supplements | 49 |
| Substance derived from starch | 29 |
| Substance essential to life | 27 |
| Substance falsely tied to food poisoning | 40 |
| Substance for a hair-raising experience? | 40 |
| Substance for a leaky radiator | 30 |
| Substance for a violin bow | 26 |
| Substance for dilating pupils | 29 |
| Substance for etching | 21 |
| Substance for making beads | 26 |
| Substance for sculptures | 24 |
| Substance for slippery wrestling | 32 |
| Substance for smelting | 22 |
| Substance for washing textiles | 30 |
| Substance found in flour | 24 |
| Substance found on unhygienic males | 35 |
| Substance from madder | 21 |
| Substance from which the universe was created | 45 |
| Substance from which the universe was created, to some | 54 |
| Substance giving red wine an astringent taste | 45 |
| Substance in a chemistry experiment | 35 |
| Substance in a seam | 19 |
| Substance in a vein | 19 |
| Substance in a visual display unit | 34 |
| Substance in acid tests | 23 |
| Substance in an oyster | 22 |
| Substance in cereals | 20 |
| Substance in chemical analysis | 30 |
| Substance in cigarettes | 23 |
| Substance in red wine | 21 |
| Substance in salad dressing | 27 |
| Substance in skin care | 22 |
| Substance in soaps | 18 |
| Substance in some cough syrups | 30 |
| Substance in some lamps | 23 |
| Substance in some piecrusts | 27 |
| Substance in some signs | 23 |
| Substance in Spandex | 20 |
| Substance in the Baseball Hall of Fame debate | 45 |
| Substance in the Nash poem "Reflection on Babies" | 59 |
| Substance in the sea's H2O | 30 |
| Substance in wheat flour | 24 |
| Substance marketed under the name NutraSweet | 44 |
| Substance obtained from some pines | 34 |
| Substance obtained from wool | 28 |
| Substance of a 1963 treaty | 26 |
| Substance of a newspaper article? | 33 |
| Substance of genetic importance | 31 |
| Substance of interest to the CIA in the 1950s | 45 |
| Substance of some crowns | 24 |
| Substance on an envelope | 24 |
| Substance on some mountains or in some lamps | 44 |
| Substance overdoer | 18 |
| Substance partner | 17 |
| Substance put on wounds | 23 |
| Substance resembling dentin | 27 |
| Substance scraped by a Zamboni | 30 |
| Substance stimulating antibody production | 41 |
| Substance susceptibility | 24 |
| Substance taken up in a lab | 27 |
| Substance that citrus peels are rich in | 39 |
| Substance that colors | 21 |
| Substance that gives red wine bite | 34 |
| Substance that makes you hot | 28 |
| Substance that may be donated | 29 |
| Substance that may darken your pasta | 36 |
| Substance that undergoes a chemical change | 42 |
| Substance under Little Cat Z's hat in "The Cat in the Hat Comes Back" | 83 |
| Substance used as an antioxidant, in some alternative medicines | 63 |
| Substance used by dyers | 23 |
| Substance used by some in baseball's Mitchell Report | 56 |
| Substance used by watchmakers | 29 |
| Substance used by whales as a feeding filter | 44 |
| Substance used for moldings | 27 |
| Substance used for polishing | 28 |
| Substance used in adhesives and paints | 38 |
| Substance used in an old punishment | 35 |
| Substance used in chemical analysis | 35 |
| Substance used in fillings? | 27 |
| Substance used in immunology | 28 |