| A South African | 15 |
| A South African capital | 23 |
| A South Asian capital | 21 |
| A south-of-the-border assent | 28 |
| A Southeast Asian | 17 |
| A Southern belle's esteem for her man? | 42 |
| A southern constellation | 24 |
| A Southern sodbuster ___ | 24 |
| A Soviet adm. division | 22 |
| A Soviet republic | 17 |
| A soybean state | 15 |
| A space between objects or points | 33 |
| A space case? | 13 |
| A spade, e.g. | 13 |
| A span of _____ | 15 |
| A Spaniard's home is his ___ | 32 |
| A Spanish 21 deck has none | 26 |
| A Spanish crowd? | 16 |
| A Spanish liqueur | 17 |
| A Spanish queen | 15 |
| A Spanish queen and namesakes | 29 |
| A spar | 6 |
| A spare one might be lost on a diet | 35 |
| A sPArkling brightness | 22 |
| A spat covers it | 16 |
| A speaker might make it | 23 |
| A special | 9 |
| A special glow | 14 |
| A special happening | 19 |
| A special número | 19 |
| A special sense | 15 |
| A species constituting a genus | 30 |
| A speck with wings | 18 |
| A spectral type | 15 |
| A speech affliction | 19 |
| A speedster may do it | 21 |
| A sphere lacks them | 19 |
| A spice | 7 |
| A Spice Girl | 12 |
| A Spinks | 8 |
| A spinner in space | 18 |
| A spiral | 8 |
| A spire is part of one | 22 |
| A spirit | 8 |
| A spirit raiser? | 16 |
| A spirited steed | 16 |
| A spiritual | 11 |
| A splitting, as of atoms | 24 |
| A sponge may get this | 21 |
| A sponge might have a big one | 29 |
| A spore is at its core | 22 |
| A sport may grab it | 19 |
| A sport of royals | 17 |
| A sport where you can score by using your head | 46 |
| A sports highlight may be seen in it | 36 |
| A sports personality who sounds like a place | 44 |
| A spot | 6 |
| A spot card | 11 |
| A spotted one might be spotted at the zoo | 41 |
| A spouse | 8 |
| A spouse in Sevilla | 19 |
| A spouse may sleep on it after a fight | 38 |
| A spouse, in Savoie | 19 |
| A spray might be used for one | 29 |
| A spread | 8 |
| A sprinkling | 12 |
| A spy may crack it | 18 |
| A spy may use one | 17 |
| A spy might work under one | 26 |
| A spy will often cross them | 27 |
| A spy, perhaps | 14 |
| A sq. is one | 12 |
| A square, Ã la Sinclair Lewis | 32 |
| A square, like Caspar Milquetoast | 33 |
| A squat, e.g. | 13 |
| A stage of man | 14 |
| A stake, metaphorically | 23 |
| A standard shown on a Royal Observatory wall | 44 |
| A standout for sure | 19 |
| A star can have a huge one | 26 |
| A star in "Rebecca": 1940 | 35 |
| A star in "The Miniver Story" | 39 |
| A star in Anaheim | 17 |
| A star in France | 16 |
| A star may have a big one | 25 |
| A star may represent it | 23 |
| A star of The Poseidon Adventure | 35 |
| A star of "Advise and Consent" | 40 |
| A star of "Cats" on Broadway | 38 |
| A star of "Cinderella Liberty" | 40 |
| A star of "Come Back to the 5 & Dime . . . " | 58 |
| A star of "Dr. Strangelove" | 37 |
| A star of "Naughty Marietta" | 38 |
| A star of "Rashomon" and "Ugetsu" | 53 |
| A star of "Seven Days in May" | 39 |
| A star of "She-Devil" | 31 |
| A star of "The Collector" | 35 |
| A star of "The Good Earth" | 36 |
| A star of "The In-Laws" | 33 |
| A star of "Vera Cruz" | 31 |