| Major coll. fraternity | 22 |
| Major company renamed in 1997 | 29 |
| Major component of soapstone | 28 |
| Major cooling-off period | 24 |
| Major defense contractor | 24 |
| Major depression out West? | 26 |
| Major diamond exporter | 22 |
| Major discount brokerage | 24 |
| Major division of a long poem | 29 |
| Major divisions in biology | 26 |
| Major divisions, in biology | 27 |
| Major e-mail deliverer | 22 |
| Major ecological community | 26 |
| Major education supporter | 25 |
| Major eight-track tape maker | 28 |
| Major elephant feature | 22 |
| Major employer in Detroit | 25 |
| Major employer in Hawaii | 24 |
| Major employer in Hiroshima | 27 |
| Major entertainment gp.? | 24 |
| Major epidemiological subject | 29 |
| Major Eur. oil exporter | 23 |
| Major Eur. oil producer | 23 |
| Major European coffee port | 26 |
| Major European waterway | 23 |
| Major event for a law student | 29 |
| Major event in golf or tennis | 29 |
| Major expense for an airline | 28 |
| Major export of Ivory Coast | 27 |
| Major exporter of coconut oil | 29 |
| Major exporter of nickel | 24 |
| Major factor in postal rates | 28 |
| Major figure in space? | 22 |
| Major financial concern | 23 |
| Major Fla.-Calif. hwy. | 22 |
| Major Fla.-to-Calif. route | 26 |
| Major food service company | 26 |
| Major football competition | 26 |
| Major for civic-minded frosh | 28 |
| Major French newspaper | 22 |
| Major General Jesse Lee ___ | 27 |
| Major German river, in German | 29 |
| Major gold exporter of Africa | 29 |
| Major handgun manufacturer | 26 |
| Major Hollywood attraction | 26 |
| Major Hollywood thoroughfare | 28 |
| Major home security corp. | 25 |
| Major Hoople expletive | 22 |
| Major Hoople's cries | 24 |
| Major Hoople's cry | 22 |
| Major Hoople's epitaph | 26 |
| Major Hoople's expletive | 28 |
| Major Hoople's expletives | 29 |
| Major Hoople's first name | 29 |
| Major Hoople's holler | 25 |
| Major Hoople's word | 23 |
| Major Houlihan portrayer | 24 |
| Major hurdle, metaphorically | 28 |
| Major hurricane of 2005 | 23 |
| Major hurricane of 2008 | 23 |
| Major impact, as of an attack | 29 |
| Major Indonesian export | 23 |
| Major industry of Madeira | 25 |
| Major interest, slangily | 24 |
| Major Istanbul attraction | 25 |
| Major Italian fashion house | 27 |
| Major Italian tourist site | 26 |
| Major Japanese carrier | 22 |
| Major Japanese seaport | 22 |
| Major Joppolo's post | 24 |
| Major Joppolo's town | 24 |
| Major Kazakhstani export | 24 |
| Major kitchen appliance | 23 |
| Major label broken up in 2012 | 29 |
| Major league ball team | 22 |
| Major League Baseball V.I.P. | 28 |
| Major league family name | 24 |
| Major league family surname | 27 |
| Major League league: Abbr. | 26 |
| Major League manager Larry | 26 |
| Major league pitcher Car-los | 28 |
| Major League pitcher, e.g. | 26 |
| Major League V.I.P.'s | 25 |
| Major League work stoppage | 26 |
| Major league, slangily | 22 |
| Major leaguer in Canada | 23 |
| Major Leaguer Stephen or J.D. | 29 |
| Major leaguers, 1969-2004 | 25 |
| Major leagues, in slang | 23 |
| Major leagues, slangily | 23 |
| Major loss, figuratively | 24 |
| Major mail handler?: Abbr. | 26 |
| Major maker of beverage cans | 28 |
| Major maker of water filters | 28 |
| Major manufacturing continent | 29 |
| Major market for U.S. exports | 29 |
| Major Middle Eastern airline | 28 |
| Major midwestern airport | 24 |
| Major military headquarters | 27 |
| Major mo. for campaigners | 25 |