| Second letters of this puzzle's five theme answers (seen in order) | 70 |
| Second letter of the Greek alphabet | 35 |
| Second letter from Greece | 25 |
| Second letter before iota | 25 |
| Second letter afterthought | 26 |
| Second letter after epsilon | 27 |
| Second letter additions | 23 |
| Second letter addendum: Abbr. | 29 |
| Second letter addendum | 22 |
| Second letter | 13 |
| Second leg | 10 |
| Second leader | 13 |
| Second largest theater chain in the U.S. | 40 |
| Second largest retailer in the U.S. | 35 |
| Second largest planet | 21 |
| Second largest of the seven | 27 |
| Second largest of the Great Lakes | 33 |
| Second largest of seven | 23 |
| Second largest of 50 | 20 |
| Second largest of the Great Lakes | 34 |
| Second largest lake in Europe | 29 |
| Second largest island in the world | 34 |
| Second largest Islam denomination | 33 |
| Second largest Hawaiian Island | 30 |
| Second largest Great Lake | 25 |
| Second largest European lake | 28 |
| Second largest city in the Czech Republic | 41 |
| Second largest city in Nicaragua | 32 |
| Second largest city in Japan | 28 |
| Second largest city in Italy | 28 |
| Second largest city in France | 29 |
| Second largest bird | 19 |
| Second largest asteroid | 23 |
| Second largest "Great Lake" | 37 |
| Second Lady Biden | 17 |
| Second lady after Tipper | 24 |
| Second job | 10 |
| Second Jimi Hendrix Experience album | 36 |
| Second issue? | 13 |
| Second Israeli ambassador to U.S. | 33 |
| Second Israeli ambassador to the U.S. | 37 |
| Second introduction? | 20 |
| Second installment | 18 |
| Second indicator? | 17 |
| Second in the kitchen | 21 |
| Second in the credits, often | 28 |
| Second in order | 15 |
| Second in line? | 15 |
| Second in evildoing | 19 |
| Second in crime | 15 |
| Second in court?: Abbr. | 23 |
| Second in command? | 18 |
| Second in command: abbr. | 24 |
| Second in command, often | 24 |
| Second in command, maybe | 24 |
| Second in command, informally | 29 |
| Second in command, briefly | 26 |
| Second in command in the state: Abbr. | 37 |
| Second in command | 17 |
| Second in cmd. | 14 |
| Second in all-time hits | 23 |
| Second in a Sue Grafton series | 30 |
| Second in a series of Web postings | 34 |
| Second in a series of sharp turns | 33 |
| Second in a series | 18 |
| Second in a Latin series | 24 |
| Second in a Greek series | 24 |
| Second in a German series | 25 |
| Second in a classical trio | 26 |
| Second in a classic Latin trio | 30 |
| Second in a certain series | 26 |
| Second impression? | 18 |
| Second human on the moon | 24 |
| Second homes for apparatchiks | 29 |
| Second home of a sort | 21 |
| Second highest, in a family of instruments | 42 |
| Second highest pinochle card | 28 |
| Second highest peak in N.A. | 27 |
| Second highest in a family of instruments | 41 |
| Second helping, to a dieter | 27 |
| Second helping, e.g. | 20 |
| Second helping | 14 |
| Second Hebrew letters | 21 |
| Second hearing? | 15 |
| Second hands: Abbr. | 19 |
| Second hand? | 12 |
| Second hand: Abbr. | 18 |
| Second hand | 11 |
| Second half of things we all memorized | 38 |
| Second half of the quote | 24 |
| Second half of quote | 20 |
| Second half of many annoyingly overenthusiastic portmanteaus | 60 |
| Second half of CLUE #2 | 22 |
| Second half of an inning | 24 |
| Second half of an exploring duo | 31 |
| Second half of an audiotape | 27 |
| Second half of an album | 23 |
| Second half of a vote | 21 |
| Second half of a TV show? | 25 |
| Second half of a ring | 21 |