| Substance stimulating antibody production | 41 |
| Substance susceptibility | 24 |
| Substance taken up in a lab | 27 |
| Substance that citrus peels are rich in | 39 |
| Substance that colors | 21 |
| Substance that gives red wine bite | 34 |
| Substance that makes you hot | 28 |
| Substance that may be donated | 29 |
| Substance that may darken your pasta | 36 |
| Substance that undergoes a chemical change | 42 |
| Substance under Little Cat Z's hat in "The Cat in the Hat Comes Back" | 83 |
| Substance used as an antioxidant, in some alternative medicines | 63 |
| Substance used by dyers | 23 |
| Substance used by some in baseball's Mitchell Report | 56 |
| Substance used by watchmakers | 29 |
| Substance used by whales as a feeding filter | 44 |
| Substance used for moldings | 27 |
| Substance used for polishing | 28 |
| Substance used in adhesives and paints | 38 |
| Substance used in an old punishment | 35 |
| Substance used in chemical analysis | 35 |
| Substance used in fillings? | 27 |
| Substance used in immunology | 28 |
| Substance used in perfumes | 26 |
| Substance used in treating acne | 31 |
| Substance used to curdle milk | 29 |
| Substance used to ignite firework fuses | 39 |
| Substance used to make ink | 26 |
| Substance used to protect or stabilize | 38 |
| Substance usually abbreviated | 29 |
| Substance whose synthesis required a "life force," alchemists believed | 80 |
| Substance with a historical museum in Amsterdam | 47 |
| Substance with a low pH | 23 |
| Substance with a pH higher than 7 | 33 |
| Substance written about in Jose Canseco's "Juiced" | 64 |
| Substance's partner | 23 |
| Substance, such as benzene | 26 |
| Substance-abusing star of "Mean Girls" in headlines | 61 |
| Substance-banning agcy. | 23 |
| Substances collectively called "the bad cholesterol" | 62 |
| Substances derived from nitrogen | 32 |
| Substances essential, in minute quantities, to nutrition | 56 |
| Substances for Strads | 21 |
| Substances in seams | 19 |
| Substances like water, vis-Ã -vis sugar | 41 |
| Substances sans liquid or gas | 29 |
| Substances similar in structure, in chemistry | 45 |
| Substances that make paint set more quickly | 43 |
| Substances that ooze out | 24 |
| Substances used by etchers | 26 |
| Substances used in chemical analysis | 36 |
| Substances used in soap | 23 |
| Substances with low pH | 22 |
| Substandard | 11 |
| Substandard contraction | 23 |
| Substandard effort | 18 |
| Substandard grade | 17 |
| Substandard item | 16 |
| Substandard language form | 25 |
| Substandard marks | 17 |
| Substantial | 11 |
| Substantial amounts | 19 |
| Substantial baby shower gift | 28 |
| Substantial bill | 16 |
| Substantial bit | 15 |
| Substantial bodies of work | 26 |
| Substantial content | 19 |
| Substantial entrees | 19 |
| Substantial food | 16 |
| Substantial hit: Abbr. | 22 |
| Substantial in scope, as a film | 31 |
| Substantial meal | 16 |
| Substantial meaning | 19 |
| Substantial plates | 18 |
| Substantial portion | 19 |
| Substantial repast | 18 |
| Substantial sandwich | 20 |
| Substantial serving of Preparation H, e.g. | 42 |
| Substantial shoe spec | 21 |
| Substantial slump | 17 |
| Substantial subs | 16 |
| Substantial sum | 15 |
| Substantial volume | 18 |
| Substantial, as a meal | 22 |
| Substantial, as a role | 22 |
| Substantial, as a sum | 21 |
| Substantial, as an amount | 25 |
| Substantial, as sums | 20 |
| Substantial, in slang | 21 |
| Substantial, sumwise | 20 |
| Substantially | 13 |
| Substantially (in) | 18 |
| Substantially fewer | 19 |
| Substantially removed (from) | 28 |
| Substantiate | 12 |
| Substantiated | 13 |
| Substantiates | 13 |
| Substantive | 11 |
| Substantive in grammar | 22 |
| Substantive part | 16 |