| Big serving bowls | 17 |
| Big servers | 11 |
| Big server | 10 |
| Big serve | 9 |
| Big series name in auto racing | 30 |
| Big seller, supposedly | 22 |
| Big seller of smoothies | 23 |
| Big seller of acetaminophen | 27 |
| Big seller in bear markets? | 27 |
| Big seller in bear markets | 26 |
| Big seller for Chris Rock | 25 |
| Big selection of meat | 21 |
| Big security device? | 20 |
| Big sections of dictionaries | 28 |
| Big section of the dictionary | 29 |
| Big section of Bartlett's: Abbr. | 36 |
| Big section of a dictionary | 27 |
| Big section in a dictionary | 27 |
| Big Seattle philanthropist | 26 |
| Big season at Toys"R"Us | 33 |
| Big season at Toys "R" Us | 35 |
| Big scuffle | 11 |
| Big screen theatre | 18 |
| Big screen pig | 14 |
| Big screen name | 15 |
| Big screen locale | 17 |
| Big screen letters | 18 |
| Big screen format | 17 |
| Big screen film format | 22 |
| Big screen | 10 |
| Big scrap | 9 |
| Big Scouts meeting | 18 |
| Big scorer alongside Yao, to fans | 33 |
| Big score, maybe | 16 |
| Big score on the floor | 22 |
| Big scissors | 12 |
| Big Schott | 10 |
| Big schlep | 10 |
| Big scary white dude | 20 |
| Big scallion | 12 |
| Big scale manufacturer | 22 |
| Big Sauvignon swig? | 19 |
| Big sandwiches | 14 |
| Big sandwich, for short | 23 |
| Big sandwich name | 17 |
| Big sandwich | 12 |
| Big salmon order for a security firm? | 37 |
| Big sale | 8 |
| Big safari men | 14 |
| Big S.A. birds | 14 |
| Big Russian lake | 16 |
| Big rushes | 10 |
| Big rush, maybe | 15 |
| Big rush | 8 |
| Big runway name | 15 |
| Big runners | 11 |
| Big runaround | 13 |
| Big rugs | 8 |
| Big rug exporter | 16 |
| Big rubber exporter | 19 |
| Big royalty generator | 21 |
| Big round hairdo, in slang | 26 |
| Big round haircut | 17 |
| Big round do | 12 |
| Big round butts | 15 |
| Big rooters for Ohio State? | 27 |
| Big rolls | 9 |
| Big roller | 10 |
| Big roll of bills | 17 |
| Big roll | 8 |
| Big role for Reese | 18 |
| Big rocket launcher | 19 |
| Big robber? | 11 |
| Big road runner | 15 |
| Big road rig | 12 |
| Big road | 8 |
| Big ringers | 11 |
| Big ringer | 10 |
| Big ring stone, slangily | 24 |
| Big ring rivals | 15 |
| Big ring | 8 |
| Big rigs, for short | 19 |
| Big rigs | 8 |
| Big rig? | 8 |
| Big rig, for short | 18 |
| Big rig on the road | 19 |
| Big rig fuel | 12 |
| Big rig fixtures, for short | 27 |
| Big rig feature | 15 |
| Big rig devices, often | 22 |
| Big rig compartment | 19 |
| Big rig | 7 |
| Big ride since 1991 | 19 |
| Big revolvers | 13 |
| Big revolver | 12 |
| Big revision | 12 |
| Big retailer of home accessories | 32 |
| Big reptiles, informally | 24 |
| Big reptile, informally | 23 |
| Big report | 10 |