| Discoverer of the Marianas: 1521 | 32 |
| Discoverer of the law of quadratic reciprocity | 46 |
| Discoverer of the Cape of Good Hope | 35 |
| Discoverer of the Amazon's mouth | 36 |
| Discoverer of Orion's fifth star | 36 |
| Discoverer of North American mainland | 37 |
| Discoverer of AntarcticaÂ’s largest ice shelf | 48 |
| Discovered some underground rock, perhaps | 41 |
| Discovered after a search, with "out" | 47 |
| Discover what makes columnist Hopper tick? | 42 |
| Discourse upon a Carthaginian general? | 38 |
| Discouraging words on the range? | 32 |
| Discouraging comment to a cloner? | 33 |
| Discount travel agency for students | 35 |
| Discount store offerings, for short | 35 |
| Discount coast-to-coast plane ticket | 36 |
| Discount carrier with "Air" | 37 |
| Discount brokerage formed in 1996 | 33 |
| Discount brokerage bigwig Charles | 33 |
| Discordia's Hellenic counterpart | 36 |
| Discordia's Greek counterpart | 33 |
| Discophile's collection | 32 |
| Discontinuing relations of any kind | 35 |
| Discontinued, with "out" | 34 |
| Discontinued robotic pet from Sony | 34 |
| Discontinued Microsoft gaming platform | 38 |
| Discontinued M&M's color | 32 |
| Discontinued investigative series? | 34 |
| Discontinued color of M&M's | 35 |
| Discontinued brand-name lawn dart, familiarly | 45 |
| Discontinued brand of antidandruff shampoo | 42 |
| Discontinued black-and-white cookie cereal | 42 |
| Discontinued (with ''out'') | 43 |
| Discommode (with "at") | 32 |
| Discommode (with ''at'') | 40 |
| Discomfort for visitors to a European nation? | 45 |
| Disco-loving "Simpsons" character | 43 |
| Disco-era term meaning 'galore' | 39 |
| Disco ___, "The Simpsons" character | 45 |
| Disco ___ of "The Simpsons" | 37 |
| Disco ___ (minor "Simpsons" character) | 48 |
| Disco ___ (character on "The Simpsons") | 49 |
| Disco ___ ("The Simpsons" character) | 46 |
| Disco ___ ("Simpsons" stereotype) | 43 |
| Disco ___ ("Simpsons" character) | 42 |
| Disco __ of "The Simpsons" | 36 |
| Disco term meaning "galore" | 37 |
| Disco song that went to #2 in 1979 | 34 |
| Disco owner on "The Simpsons" | 39 |
| Disco hit "Got to Be ___" | 35 |
| Disco guy on "The Simpsons" | 37 |
| Disco fan on "The Simpsons" | 37 |
| Disco fan on 'The Simpsons' | 35 |
| Disco classic with associated hand motions | 42 |
| Disco Biscuits festival Camp ___ | 32 |
| Disco Biscuits "___ for a Day" | 40 |
| Disclosure to a loan applicant: Abbr. | 37 |
| Disclaimer letters before a message board comment | 49 |
| Discipline with a "warrior pose" | 42 |
| Discipline that means "skill" | 39 |
| Discipline symbolized by a painted circle | 41 |
| Discipline involving slow, steady movement | 42 |
| Discipline involving slow movement | 34 |
| Discipline dealing with living organisms | 40 |
| Disciple: "Golden ___" | 32 |
| Disciple of Jesus who began as a tax collector | 46 |
| Discharge sought by Klinger on "MASH" | 47 |
| Discharge from the military, informally | 39 |
| Discharge from military service, informally | 43 |
| Discharge between two electrodes | 32 |
| Disc-shaped vacuum cleaner from iRobot | 38 |
| Disc used in a fad game of the 1990s | 36 |
| Disc thrown in the game of Ultimate | 35 |
| Disc jockey's attention-getter? | 35 |
| Disaster often not covered by insurance | 39 |
| Disaster at a flooded smokehouse? | 33 |
| Disaster area operation, for short | 34 |
| Disassembles, as a model airplane | 33 |
| Disapprovers' demonstrations | 32 |
| Disappointments for baseball fans | 33 |
| Disappointment for ticket purchasers | 36 |
| Disappointing snack for Bugs Bunny? | 35 |
| Disappointing news about a sale item | 36 |
| Disappointing Chicago Bears draft pick Curtis | 45 |
| Disappointed Olympic team members, maybe | 40 |
| Disappointed interjections from Dirk Nowitzki | 45 |
| Disappoint, with "down" | 33 |
| Disappoint the Blue Fairy, in a way | 35 |
| Disappoint (with "down") | 34 |
| Disappoint (with ''down'') | 42 |
| Disappears like the Wicked Witch of the West | 44 |
| Disappearing network TV employee | 32 |
| Disappearing communication device | 33 |
| Disappeared, with "off" | 33 |
| Disappear, with "away" | 32 |
| Disappear, like a moving vehicle? | 33 |
| Disappear, as time during a blast | 33 |
| Disappear from the radar, so to speak | 37 |
| Disagreement of biblical proportions? | 37 |
| Disaccustom (with ''from'') | 43 |